Protein Alignment FXR1 and Fmr1

DIOPT Version :10

• Sequence 1: NP_001428438.1
• Gene: FXR1 / 8087
• HGNCID: 4023
• Length: 677
• Species: Homo sapiens
• Sequence 2: NP_001247017.1
• Gene: Fmr1 / 37528
• FlyBaseID: FBgn0028734
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 722
• Identity: 267/722 - (36%)
• Similarity: 394/722 - (54%)
• Gaps: 86/722 - (11%)

Human     1 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPE-RQVPFNEVRLPPPPDIKKE---ISE 61
            |.:|.||||..|||:|||.:..|.:|.:.|  :.:..|| .:.||..|||||...::..   ..|
  Fly    49 MEDLLVEVRLDNGAYYKGQVTAVADDGIFV--DVDGVPESMKYPFVNVRLPPEETVEVAAPIFEE 111

Human    62 GDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTF 126
            |.||||::|.||:|.||||:..::|.|.|.|.:.|...:.:|.||....|||..|.|..:...||
  Fly   112 GMEVEVFTRTNDRETCGWWVGIIKMRKAEIYAVAYIGFETSYTEICELGRLRAKNSNPPITAKTF 176

Human   127 FKCTVDVPEDLREACANENAHKDFKKAV--GACRIFYHPETTQLMILSASEATVKRVNILSDMHL 189
            ::.|:.|||:|||....:..||:|::.:  |.|.  |..:...|:::|..|.|.||.::|.|||.
  Fly   177 YQFTLPVPEELREEAQKDGIHKEFQRTIDAGVCN--YSRDLDALIVISKFEHTQKRASMLKDMHF 239

Human   190 RSIRTKLMLMSRNEEATKHLECTKQLAAA-FHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAI 253
            |::..|:||:.|.|||.:.||.||.::.. :.|||.||:||||||||:||||||.||.|.|||.|
  Fly   240 RNLSQKVMLLKRTEEAARQLETTKLMSRGNYVEEFRVRDDLMGLAIGSHGSNIQAARTVDGVTNI 304

Human   254 ELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRI 318
            ||:|.:.||:|.||:.::|::||..||:.|:|.||||.||||||||||::||||||||||.|::|
  Fly   305 ELEEKSCTFKISGETEESVQRARAMLEYAEEFFQVPRELVGKVIGKNGRIIQEIVDKSGVFRIKI 369

Human   319 EGDNE--NKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQI--- 378
            .||:|  ..:|||...|||||:||.|||.|.:||||||:::||||||||.|:::||:|||.|
  Fly   370 AGDDEQDQNIPRELAHVPFVFIGTVESIANAKVLLEYHLSHLKEVEQLRQEKMEIDQQLRAIQES 434

Human   379 GMGFRPSSTRGPEKEKGYATDESTVSSVQ-GSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETES 442
            .||...|.......|:||::|..:|.|:: |.....||.|||.|.....|.|.|....|
  Fly   435 SMGSTQSFPVTRRSERGYSSDIESVRSMRGGGGGQRGRVRGRGGGGPGGGNGLNQRYHN------ 493

Human   443 ERKDELSDWSLAGEDDRDSR--HQRDSRR----RPGG--RGRSVSGGRGRGGP----RGGKSSIS 495
            .|:|         |||.:||  ||||.:|    |.||  .|....||.|.|||    |||
  Fly   494 NRRD---------EDDYNSRGDHQRDQQRGYNDRGGGDNTGSYRGGGGGAGGPGNNRRGG----- 544

Human   496 SVLKDPDSNPY--------------SLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVL 546
             :.:.|..|..              .:.:..|.......|::.|:..::||||.::..
  Fly   545 -INRRPPRNDQQNGRDYQHHNHTTEEVRETREMSSVERADSNSSYEGSSRRRRRQKNN------- 601

Human   547 MDGMTESDTASVNENGLDDSEKKPQRR------NRSRRRRFRGQAEDRQPVTVADYISRAESQSR 605
             :|.:.::.|..|.|....|.::||::      |::.........::......|...|:.:..|
  Fly   602 -NGPSNTNGAVANNNNKPQSAQQPQQQQPPAPGNKAALNAGDASKQNSGNANAAGGASKPKDAS- 664

Human   606 QRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEA 670
             ||..::.....:::.::  :::...:::....|........:...:..|::::    .||.::.
  Fly   665 -RNGDKQQAGTQQQQPSQ--VQQQQAAQQQQPKPRRNKNRSNNHTDQPSGQQQL----AENVKKE 722

Human   671 AVLNGVS 677
            .::||.|
  Fly   723 GLVNGTS 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FXR1	NP_001428438.1	None
Fmr1	NP_001247017.1	Tudor_Agenet_FMRP-like_rpt1	51..99	CDD:410473	22/49 (45%)
		Tudor_SF	111..176	CDD:470623	27/64 (42%)
		KH_I_FMR1_FXR_rpt1	173..249	CDD:411853	28/77 (36%)
		KH_I_FMR1_FXR_rpt2	270..331	CDD:411854	37/60 (62%)
		KH_I_FMR1_FXR_rpt3	332..411	CDD:411855	51/78 (65%)
		FXMRP1_C_core	407..>455	CDD:463501	22/47 (47%)