Protein Alignment SH3BP5L and CG14408

DIOPT Version :10

• Sequence 1: NP_085148.1
• Gene: SH3BP5L / 80851
• HGNCID: 29360
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_727792.2
• Gene: CG14408 / 32407
• FlyBaseID: FBgn0030581
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 467
• Identity: 138/467 - (29%)
• Similarity: 199/467 - (42%)
• Gaps: 156/467 - (33%)

Human    48 LSPREEEELDPRIQEELEHLNQASEEINQVELQLDEARTTYRRILQESARKLNTQGSHLGSCIEK 112
            :|......:|||:|.|||.||.|::.||:.|::||||:..::|:|.||..::......||:.|:.
  Fly     1 MSTESNTPVDPRVQVELEKLNSATDNINRYEVELDEAKCEFKRLLAESVVRIKAAAHKLGNSIDA 65

Human   113 ARPYYEARRLAKEAQQETQKAALRYERAVSMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHAT 177
            |:||||:|..|.:..:|||.||..:|:|.|:|.||:|||::|||| :.:|:.||...||||:||.
  Fly    66 AKPYYESRIYAAQLAKETQLAAANHEKAKSIHAAAKEMVYLAEQG-LGEKSTLDTACQEMLSHAA 129

Human   178 CKVNEAEEERLRGEREHQRVTRLCQ----QAEARVQALQKTLRRAIGKSR--------------- 223
            .|||:::.|    ..:.:...::||    .|..||..||..|::|:..||
  Fly   130 SKVNQSQLE----VTDTRNALKMCQLKLEVANNRVGKLQGQLKQALRASRLQLKRNLLLLRYFSI 190

Human   224 ----------PYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVALRNLEQISEQIHARRR-- 276
                      ||:|.:|.::.:|:..|.:|.|||.:|:.||..|:.||:|||||||.||.:|:
  Fly   191 MHALYCTLCSPYYETRANYNGLLKAQKTRVNELEAKVSAAKLTYNEALKNLEQISEDIHRQRQQR 255

Human   277 --------------------GGLP----------------------------------------- 280
                                .||.
  Fly   256 NNLLNYEAMLRQVDAVDTLTAGLERSSCGTAANRQDLEAKAAAEEQKHVEAEAEEEEEEYLRMPE 320

Human   281 -------PHPL---------------GPRRSSPVGAEAGPEDMEDGDSGI---------EGAEGA 314
                   ||.|               |..:|:..||.|      ||::|:         |...|:
  Fly   321 RLGHHECPHLLTDFEAVLTFPQKLAGGMHKSASTGAAA------DGEAGLGPLGLHAPYEVKSGS 379

Human   315 G-LEEGS-----SLGPGPAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHVSLDGQELGTRSG 373
            | |..||     |.|..|| |.|......:|...||             |...|...|.|..:.|
  Fly   380 GSLASGSASVSTSAGGAPA-DNDIEQWTEIRLSHSD-------------STSSSYSNQSLLEQQG 430

Human   374 GRRGSDGGARGG 385
              ..|.||..||
  Fly   431 --LDSTGGMSGG 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3BP5L	NP_085148.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		1/9 (11%)
		SH3BP5	54..283	CDD:461608	102/327 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..332		25/158 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..393		9/24 (38%)
CG14408	NP_727792.2	SH3BP5	9..256	CDD:461608	99/251 (39%)