DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KMT2D and SET2

DIOPT Version :9

Sequence 1:	XP_011537072.1	Gene:	KMT2D / 8085	HGNCID:	7133	Length:	5556	Species:	Homo sapiens
Sequence 2:	NP_012367.2	Gene:	SET2 / 853271	SGDID:	S000003704	Length:	733	Species:	Saccharomyces cerevisiae

Alignment Length:	150	Identity:	49/150 - (32%)
Similarity:	85/150 - (56%)	Gaps:	8/150 - (5%)

- Green bases have known domain annotations that are detailed below.

Human  5406 QYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKI--YEEQN-R 5467
            |.:|.:.:....:.:.:::.:|.|:.|.:|:|.:..:.||.|.:|  |....|:::  |:::: :
Yeast   110 QNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVI--EEMEFRDRLIDYDQRHFK 172

Human  5468 GIYMFRINNEHVIDATLTGGPARYINHSCAPNC-VAEVVTFDKEDKIIIISSRRIPKGEELTYDY 5531
            ..|...:.|...||||:.|..||:.||||:||. |.:.|..||. ::.|.:.|:|.||||:|:||
Yeast   173 HFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKL-RMGIFAQRKILKGEEITFDY 236

Human  5532 QFDFEDDQHKIPCHCGAWNC 5551
            ..|....|.: .|:|...||
Yeast   237 NVDRYGAQAQ-KCYCEEPNC 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KMT2D	XP_011537072.1	None
SET2	NP_012367.2	AWS	64..119	CDD:197795	2/8 (25%)
		SET_SETD2	119..260	CDD:380949	46/140 (33%)
		SET	215..695	CDD:225491	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940