DRSC/TRiP Functional Genomics Resources

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Protein Alignment KMT2D and pps

DIOPT Version :9

Sequence 1:XP_011537072.1 Gene:KMT2D / 8085 HGNCID:7133 Length:5556 Species:Homo sapiens
Sequence 2:NP_001247075.1 Gene:pps / 41524 FlyBaseID:FBgn0082831 Length:2018 Species:Drosophila melanogaster


Alignment Length:2151 Identity:420/2151 - (19%)
Similarity:636/2151 - (29%) Gaps:793/2151 - (36%)


- Green bases have known domain annotations that are detailed below.


Human   705 SPASPPPE------DSLMSLPLE--------ESP----LLPLPEEPQLCPRSEGPHLSPRPEEPH 751
            :|.:.|.:      |..|::.::        ::|    |:...:..|..|.|        |.:..
  Fly   206 TPFTSPEQLKNHKRDEKMAMEMQAQSRKIIMQAPGSVKLINAKKRVQAIPLS--------PVQVK 262

Human   752 LSPRPEEPH-------LSPQAE---EPHLSPQPEEPCLCAVPE-------EPHLSPQAEGPHLSP 799
            :...|.:||       |.|:.:   :|..||.|.:.     ||       ...|.|......:..
  Fly   263 VQRLPVKPHQVQQAAQLQPKVQLIRKPIHSPLPRQK-----PEIIANNSVNARLRPTRAPVKVIA 322

Human   800 QPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPEL-----EKPP 859
            .|.:.::. ..::...|...||.......:...:|.:|:|...|....:|.:..::     ..|.
  Fly   323 PPVQEYIE-DDDDAQSSDSAEEENADKAYDSEEMSEESDEFQESDNDRDSDMDFDMRHSNRRNPN 386

Human   860 LSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLG------EPALSEPGE----PPLSPLPEE 914
            ...|..|...   |.|:....||.|||..|...|.|.      ||...:.|:    |....:|..
  Fly   387 KRKRVRKVVR---QTPSKPMKPLPPPPTTPQHFPELKKRKEVLEPKAPQIGQIIQMPATKSVPAV 448

Human   915 LPLSPSGEPSLS-----------PQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSD 968
            ..|. .|.||.|           |...||.|..|..|.:   ...||:. ||.:           
  Fly   449 FALG-RGLPSTSFLKIRPTHQSLPVKRPPLPTTPANSNV---RRMPAVQ-LGRI----------- 497

Human   969 PESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVG-----------------PASPIL 1016
                                 ...|:.|..:|:..:..||.|                 .:||: 
  Fly   498 ---------------------VNSPQEVKEIIINKNMASPKGVFTNLNTLLGEDNNAATKSSPV- 540

Human  1017 MEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSP---------LSPIGKVVGVSDEAELHE 1072
                     ||...:::..::|.|..:....|:.||.|         ..|||     .|.|:.|:
  Fly   541 ---------PLRHRAVMSPSTPRSSYNQQMSPIVVPVPAQAHTPSKGFMPIG-----VDTAQSHK 591

Human  1073 M-----------------ETEK------------------VSEPECPALE--PSATSPLPSPMGD 1100
            :                 |.:|                  |.:|...|.|  |.....|.|...|
  Fly   592 LPAQIVIETHQSSSELAAENDKQLDLINSIVQDELLKSTLVEQPVVNADEDIPKLVKMLESTAAD 656

Human  1101 LSCPAPS------PAPALDDFSGLGE----------DTAPLDGIDAP------GSQPEPGQTPGS 1143
            |..|..|      |||   :..|:|.          |||..|.|.|.      |...|..|....
  Fly   657 LDPPPVSLPTNIFPAP---EMQGVGNAAAADPNNIMDTANEDEITADFLQHVVGLIEEDKQFEAE 718

Human  1144 LASELKGS--PVLLD-----PEELAPVTPMEV------YPECKQTAGQGS----PCEEQEEPRAP 1191
            :..::..|  |..||     |..:.||...:|      .|....|....|    |.......|:.
  Fly   719 VVKQVLASTEPGTLDAIVSMPTSIEPVDVPQVQAHTNLLPNASLTEPAQSMTSLPIACSTPSRSV 783

Human  1192 VAPTPPTLIKSDIVNEISNL----------SQGDASASFPGSEPLLGSPDPEGGGSLSMELGVST 1246
            .|.||||..|  :|.....:          ::....|.|| |.|.:.:......|:||  .|.|:
  Fly   784 AASTPPTSAK--VVRGYGRVIYLPPIEAPTTRAKRRAQFP-SAPGMAATSSSDAGNLS--FGESS 843

Human  1247 -DVSPARDEGSLRLCTDSLPETDDSLLCDAGTAISGGK----AEGEKGRRRSSPARSRIKQGRSS 1306
             |.|..:...:..|..||.|.             ||.|    .|....||.::|.||:       
  Fly   844 LDASINQPLNTSSLSNDSQPG-------------SGPKRPNPREPSMARRSTAPRRSK------- 888

Human  1307 SFPGRRRPRGGAHGGRGRGRARLKSTASSIETLVVADIDSSPSKEEEEEDDDTMQNTVVLFSNTD 1371
                                   |..||.         ::.|...|.:||||....         
  Fly   889 -----------------------KLDASQ---------NNDPDASESQEDDDDPNK--------- 912

Human  1372 KFVLMQDMCVVCGSFGRGAEGH----LLACSQCSQCYHPYCVNSKITKVMLL----KG--WRCVE 1426
                   :..:|      .:.|    ::.|..|...:|..||.  :||.|..    ||  |:|.:
  Fly   913 -------LWCIC------RQPHNNRFMICCDLCEDWFHGTCVG--VTKAMGTDMENKGIDWKCPK 962

Human  1427 CI-----------------------------------VCEVCGQA--SDPSRLLLCDDCDISYHT 1454
            |:                                   ..|:...|  |.|.|.|           
  Fly   963 CVKRQEERSQPRITDMLVTRPTTQPEQRPSETKVLTTTAEIVQVAAPSAPRRTL----------- 1016

Human  1455 YCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPC----ASLVTCPICHAP-- 1513
                |.:|||.....:........:....:.....:.|.::...||.    .|...|.:|..|  
  Fly  1017 ----PVVLTVASSPMRIPMAKPAKKFPTGAISHQQQQQLNFIRLGPSPGKRISETLCVVCKRPAS 1077

Human  1514 ----YVEEDLL-------IQCRHCERW---MHAGCESLFTE--DDVEQAADEGFDCVSCQPYVVK 1562
                |..|:.:       ||.....:.   .:||.:||...  |..:....:.|:.|..|...|.
  Fly  1078 TSSVYCGEECIRKYAQSAIQAHAATKGPLPQNAGAQSLLNNSFDAKKNKKKDLFEDVLRQADTVS 1142

Human  1563 PVAPVAPPELVPMKV----KEPEPQYFRFEGVWLTET-GMALLRNLTMSPLHKRRQRRGRLGLPG 1622
            .|..:...|....:|    ..|....||   .||.|. ...:|.:.|:....  .::|...|.| 
  Fly  1143 KVERINVFERKSGRVITGHMAPSAHQFR---KWLQENPSFEVLPSGTVQSAD--AEKRLLKGAP- 1201

Human  1623 EAGLEGSEPSDALGPDDKKDGDLDTDELLKGEGGVEH-----MECEIKLE-GPVSPDVEPGKEET 1681
            ||....|||: .||...|..         :|...:.|     ::...:|. ..|.|..:..||:|
  Fly  1202 EAATSTSEPA-VLGVAKKPP---------EGPAKLSHPQNTTVQASHQLGISSVRPLAKKDKEKT 1256

Human  1682 EESKKR---------KRKPYRPGIGGFMVRQRKSHTRTKKGPAAQAEVLSGDGQP-DEGETVIPA 1736
            ..:.:.         |.:|.|.||...:..|..:  |.|:..||:    ...||| .:..||:..
  Fly  1257 TPTVQAPTPNRIAAGKPEPVRIGIRRSLREQLLA--RIKEAQAAE----ENSGQPTTQWPTVLEV 1315

Human  1737 D---------------------------------------------------------LPAEGAV 1744
            |                                                         :..|...
  Fly  1316 DQFVKNVELEMFNSFGRDVGAKYKAKYRSLMFNIKDRKNRTLFEKICAKQVEPRQLVRMTPEQLA 1380

Human  1745 EQSLAE-GDEKKKQQRRGRKKSKLEDMFPA--YLQEAFFGKELL--------------------D 1786
            .|.||: .:|:.:.|....|||:|:.:..|  |:.:...|:|::                    |
  Fly  1381 SQELAKWREEENRHQLDMIKKSELDLLACAQNYVVKTHKGEEVIATKVDVTLPEENVSEASSMAD 1445

Human  1787 LSRKALFAVGVGRPSFG-LGTPKAKGDGGSERKELPTSQK------------------------- 1825
            ..:.:|    |..||.. |....::...||.:::...|.|                         
  Fly  1446 TKQTSL----VSEPSTSTLERSTSREKAGSSKEKRHKSHKHHHRKRSRSRSNSRGRSVDKRHRRQ 1506

Human  1826 ---GDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDPEKPGTPGEGMLSSDLDRISTEELP 1887
               |.:.|...:.|.|..|.::    .|...:..||:|...::          :|...:..:...
  Fly  1507 HNEGGEQPGSGEREHRSREKQS----RERDEIVPSPLPKKRDE----------NDQSPVPKKTAE 1557

Human  1888 KMESKDLQQLFKDVLGSER--EQHLGCGTPGLEGSRTPLQRPFLQGGLPLGNLPSS----SPMDS 1946
            |........|...:|.||:  ||....|.|          :|   ...||..||||    .|||:
  Fly  1558 KKTEASAYNLVDQILESEKTVEQAANLGKP----------KP---SPKPLPTLPSSLKAPEPMDN 1609

Human  1947 YPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEK 2011
            |     |.:|                      .|.||.|.                      |..
  Fly  1610 Y-----SRYL----------------------HGLTTSSL----------------------WSG 1625

Human  2012 DEELGQLSTISPVLY---ANIN-FPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRA 2072
            ..::..|:....|:|   .|.: ..||.....|...|..:: .:|..:....|:|..:..     
  Fly  1626 TLKMIDLADFEIVMYPVQGNCHQLGNLMPSQMDVIGRITRV-NVWEYIKKLKKSPTKEVV----- 1684

Human  2073 AHRINKVQKQAESQ----------INKQTKVGDIARKTDRPALHLRIPPQPGALGSP---PPA-- 2122
               |..:...:.|:          ::.:.::|.:...:|:.......|     |||.   |||  
  Fly  1685 ---IVNIFPASPSETYKFDLFFEYLDSRQRLGVLGVDSDQIRDFYIFP-----LGSGDKLPPALQ 1741

Human  2123 -AAPTIFIGS---PTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLA 2183
             |.|..|...   |.|..|:....  ..|.||.:||.           .|.||..||:       
  Fly  1742 TAEPVPFYEEAQRPNTLLGIIVRC--LSKRPADAVPS-----------TPSVPTPVPA------- 1786

Human  2184 PAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEF--------------HTTPP 2234
                |..:......:...||:.:.     |....|:...:.:..||              .|.|.
  Fly  1787 ----LSSKVAKRSRSSISYPAQSS-----PKRKISTHSTSSKDDEFDIDAIIKAPIAKLQKTAPK 1842

Human  2235 GTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPP--PFGESRKALEVKK----- 2292
            ..|  |||.|:...:|..|              ||...|.:.|.|  |....|:..|:.|     
  Fly  1843 VVP--QPSVPNDADEPYSP--------------GGSDDELVPSAPQRPNDLERQVNEINKQIAAQ 1891

Human  2293 ----------EELGASSPSYG------PPNLGFV--------DSPSSGTHLGGLELKTPDVFKAP 2333
                      |..|::|.|..      |.||..:        :.|||... |..|....|...| 
  Fly  1892 QMEIAGLLKVEPTGSASSSNVLAAISIPANLSKILASIKDKTNLPSSADD-GDEEYNPEDDITA- 1954

Human  2334 LTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYT-DPYAQPPLTPRPQPPPPES 2397
             |...:..:|:|.|   |......|:.|:..|.:...:....|.| ...||.||||.|.||||  
  Fly  1955 -TSSFASKKPRSKG---RLAHLSEAELLSMVPDNLAGVIPRSSRTRHQLAQSPLTPTPLPPPP-- 2013

Human  2398 CCALPP 2403
                ||
  Fly  2014 ----PP 2015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KMT2DXP_011537072.1 None
ppsNP_001247075.1 TNG2 <827..965 CDD:227367 44/215 (20%)
PHD_PHF3_like 914..963 CDD:277027 14/56 (25%)
BRK 1142..1186 CDD:197800 10/46 (22%)
TFIIS_M 1274..1396 CDD:284835 20/127 (16%)
SPOC 1623..1729 CDD:285043 16/114 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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