Protein Alignment KMT2D and upSET

DIOPT Version :9

• Sequence 1: XP_011537072.1
• Gene: KMT2D / 8085
• HGNCID: 7133
• Length: 5556
• Species: Homo sapiens
• Sequence 2: NP_001261819.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Alignment Length: 3301
• Identity: 667/3301 - (20%)
• Similarity: 1003/3301 - (30%)
• Gaps: 1126/3301 - (34%)

Human  2254 SLDNLAV-PESPGVGGGKAS-----------EPLLSPPPF----GES------------------ 2284
            |.|::.| |.....|||..|           :|   |||.    |.|
  Fly     5 SHDSVFVEPAVSSSGGGSTSSINRIGVASGPQP---PPPHIVIDGSSLSTQAQLRIMQRRMSIST 66

Human  2285 RKALEVKKEELGASSPSY--------GPPNLGFVDSPSSGTHLGGLELKTPDVFK---------- 2331
            |:.|...:.:....|..|        |....|...|.|||.     ||..|.::|
  Fly    67 RQILSASQSQSINQSQKYAVRTAAGTGALAAGAASSGSSGQ-----ELINPQIYKIVTTDGSTSN 126

Human  2332 --------AP------LTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPY- 2381
                    ||      |....:.:..|:|..|...|:......|             |:.:.||
  Fly   127 VIIDASAAAPPHNSKLLLSNLTVLSKQAPVQGAAGQQQQQLNYL-------------GAKSLPYV 178

Human  2382 AQPPLTPRPQPPPPESCCAL----------PPRSLPSDPF---------SRVPASPQSQSSSQSP 2427
            :..|...:.||....|..|.          |..:|.....         |.||||| ||...| |
  Fly   179 SASPAKTQQQPQKFGSISAFKAQHQQQQQHPHATLQKVTLGSRVATRLQSYVPASP-SQIMVQ-P 241

Human  2428 LTPRPLSAEAF-----------CPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPP---RPQPP 2478
            ..|:.::|.|.           ....:|.:..|.....:...:.|.:.......:..   ..|..
  Fly   242 AQPKYVNATATTIGGNAALLKKANQKITVKSVSNMSQQQQQQQQQQQQQLLQAQQLKTFITQQQQ 306

Human  2479 EVAFKAGSLAH-----TSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMR 2538
            :..:|||:.|.     |:|..    ||||.......:||               .:.|.|.:|.:
  Fly   307 QQTYKAGAKAKFVKQTTALSI----AALPQQQQQTTYAK---------------QSMVTTSTPAK 352

Human  2539 FTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGS 2603
            .|        .|.....|..:..|.|........|.:           ||    .|..|..|..:
  Fly   353 VT--------KLNSKYVQQQISLPQGTQLQHKASPNV-----------TG----GGYLLQQSQAA 394

Human  2604 TGESYGLSPLRPPSVLPPPAPDGSLPYL-SHG-----------ASQRSGITSPVEKREDPGTGMG 2656
            .|                    |::.:: |||           |::|:...|......:......
  Fly   395 VG--------------------GTIKFVNSHGTVIQQHPQQQQATKRTHYNSSGSSDNEQHAVAN 439

Human  2657 SSLATAE---LPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEK--ETAAAAAGA 2716
            |||.|.:   :.|||                ....|...:::...|::..:|::  :..|..:|.
  Fly   440 SSLITDDVMIVNGTQ----------------MTDELSARILQSMAQKSFSQQQRFHQVPATGSGN 488

Human  2717 VGPP--------GSWGAEPSSP---AFEQLSRGQTPFAGTQDKSS-----LVGLPPSKLSGPILG 2765
            :.||        .|.||..|||   |...:.......|||:..||     :.|.||..:
  Fly   489 MPPPTQIIYSNSTSNGAAASSPGGNASGNMLLAHYQAAGTKPVSSASFITVTGTPPVTV------ 547

Human  2766 PGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAF-----------YQRAPYPGSLPLQQQQQQ 2819
                            ||..|:.::|.....||.|.           .|....|.|..:..:::|
  Fly   548 ----------------ATTPSVSISSHGFASGSAAISSYMSSATAARRQSVSAPSSRAVSLERKQ 596

Human  2820 LWQQQQ-----------------------ATAATSMRFAMSARFPSTPGPELGRQALGSPLAGIS 2861
            ..||.|                       :...:|...|.|....:..||   |...||   |.:
  Fly   597 HHQQLQHDVIGGGRKAPTVIEYYNKHGVNSIVGSSNNLAQSNSMSNLAGP---RSNSGS---GFA 655

Human  2862 TRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQG---PPQRPRFYPVSEDPHRLAPEG 2923
            |       ..|.||.|.....:...|.....|..:|...:|   ||.:|:  ...:..|.|.|..
  Fly   656 T-------TTPTPATPLHLTPVNVPVHVEAAPPSSPALVKGSSQPPAQPQ--QQQQQAHPLGPNQ 711

Human  2924 LRG----LAVSGLPPQKPSAPPAPELNNSL---------------------HPTPHTKGPTLPTG 2963
            |..    |.:.       ...|.|.|...|                     .|.......|.|..
  Fly   712 LNANDEELYIE-------EVRPVPVLTQDLRLQQLHAIMQDHTYASQQQQQQPQQAAGDTTNPGA 769

Human  2964 LELVNRPPS----------STELGRPNPLALEAGKLPCEDPELDDDFDAHKALEDDEELAHLGL- 3017
            .:.|.:|..          |...|.|..:.........:......|.|||.|:...   :.:||
  Fly   770 AQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSS---SRMGLA 831

Human  3018 GVDVAKGDDELGTLENLETNDPHLD----DLLNGDEFDLL-----AYTDPELDTGDKKDIFNEHL 3073
            ..|:..| :|..|....|..|..:.    :|.:.|.:.:.     |:...:....|:::|..|::
  Fly   832 STDIDPG-EETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYM 895

Human  3074 ------RLVESA------NEKAEREALLRGVE--------------PGPLGPEERPPPAADASEP 3112
                  |.|:.|      .:|.:...||...:              .|.||   ...|.::..:.
  Fly   896 CELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLG---SGLPMSEELQH 957

Human  3113 RLASVLPEVKPKVEEGGRHPSPCQFTIAT------PKVEPAPAANSLGLGLKPGQSMMGSRDTRM 3171
            ||||.|        .||       |...|      .|.:....:.|.....|.....||......
  Fly   958 RLASGL--------NGG-------FATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNAS 1007

Human  3172 GTG-PFSSSGHTAEKAS--------FGATGGPPAHLLTPSPLSGPGGSSLLEKFELESGALTLPG 3227
            |:| |..|||.|::|:|        .|::||..:..||.:..........:|.:|.   |:|...
  Fly  1008 GSGTPTGSSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEY---AVTNHY 1069

Human  3228 GPAASGDELDKMESSLVA-SELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSA 3291
            .|        ::.:.|.| .:.|.|::.:...|.|.|::.||   ||..|...:|.:|:..|:..
  Fly  1070 SP--------ELRARLHAIQKQPSLLQSIQNTENKALRQIQQ---QLSTAGSAEQLEQRAQLIPY 1123

Human  3292 PGPAQAMS----LPHEGSSP--SLAGSQQQLSLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSM 3350
            .|....:|    .||   :|  .|.|...     |....:...|...|.|.||::.|.
  Fly  1124 AGAKVLISSVDLSPH---APIHELRGKYM-----LTTQFRTQNPTVNMNTPPPSNYLN------- 1173

Human  3351 AMVSNQGHMLSGQH-------GGQAGLVPQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLAN- 3407
               |.:.|...||.       |.:|   |.|:.:|..|...:...|||....|:.....:...|
  Fly  1174 ---SFKAHKTPGQFVFFYQLPGVEA---PMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGND 1232

Human  3408 ------SFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLS 3466
                  |..|:.:|..:..:..:    ...:|||..|:   ||..|.:..
  Fly  1233 ARFVRRSCRPNAELQHYFEKGTL----HLYIVALTHIR---AQTEITIRH--------------- 1275

Human  3467 GGPSSDLQNHVAAGSGQERSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVL 3531
                   :.|......|::|.....||.........|          .:.||.....:|.||:..
  Fly  1276 -------EPHDLTAVEQKKSHAAVIQPTSTRCACDMG----------SDCLFALPLAVQQQLQAP 1323

Human  3532 EEQ-IGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLD-QVRKQQKEHTNL 3594
            ..| ...||....|..|....|..|                   :.||..:. .|........::
  Fly  1324 PTQPRSSHRNKAAAAAAAAAAANSA-------------------AAIQLTMGLGVGATVAAGASV 1369

Human  3595 MAEYRNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAG-GL 3658
            :...||:......:..|.                              ||..||   .||.. |.
  Fly  1370 LPNSRNRSTSSSGESSQM------------------------------GLNSPQ---LGQLNLGF 1401

Human  3659 RLTPGGMALPGQPGGPFLNTALAQQQQQQHSGGAGSLA------GPSGGFFPGNLALRSLGPDSR 3717
            :.:....:|.....|...|          :|||:.|.:      ..|.......:...|..|...
  Fly  1402 KTSVTATSLTAPVPGVHCN----------NSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVS 1456

Human  3718 LLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPP 3782
            :......|:|...:|     |..||..|||..||.:...||.||        |.|...|..::.|
  Fly  1457 IPSPTPTQMQSPTLQ-----QHPQQIPQQQLSLLQRSPTQQHQQ--------QILAALPTPMLTP 1508

Human  3783 SSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQG 3847
                     .||||.|:       |||    ||.|            |::.||:..|
  Fly  1509 ---------MLSPQLPK-------PAQ----QQAH------------VVLPQSQQTS-------- 1533

Human  3848 QGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQ 3912
                     ..||||.||..:....:|..:..||.:.::     ...||     |.|||||..:.
  Fly  1534 ---------LLQQQQSQQSQEPLAVIAAAAAAQQPMATY-----FVRQP-----QQQQQQQSPKP 1579

Human  3913 QQLQQQQQQQL---QQQQQLQQQQLQQQQQ--------------------------------QQQ 3942
            |.|..|||..:   |||..|||||.|||||                                |||
  Fly  1580 QALVAQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQ 1644

Human  3943 LQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQ-------QQQVAL 4000
            .|.|||||...||...||..|||..|.||||.||.    |..:   |||:||       |.|:.:
  Fly  1645 SQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQP----NYPQ---SPQRQQKPQPVQHQPQIVI 1702

Human  4001 GPG---MPAKPLQHFSSP-GALGPTL------------LLTGKEQNTVDPAVSSEATEGPSTHQG 4049
            ..|   :||......||| .:..|.:            ::.||:.....|....:..:.|.|...
  Fly  1703 STGAQAIPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVS 1767

Human  4050 GPLAIGTTPESMATEPGEVK-PSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHT 4113
            ...|...||.|..::..:|. .|.:..:.....:.:|:......:|:..||...:.::|     .
  Fly  1768 AATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQ-----E 1827

Human  4114 AGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGP---------------QQPML 4163
            |.|....:..||...:||:.|   |.|:..  :...|:::::..|               ::..:
  Fly  1828 ARGKKDTRQSSGGKRQASNSP---ASPNKR--NSSNSISEDVETPTSTNSAAAAAQRRNKKKRKV 1887

Human  4164 ERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQAL 4228
            .|.:.|||..        |.||.|                     :.|.:.:.:..:...:..||
  Fly  1888 SRSLNNNTNG--------LGSGGG---------------------SNNKRRKSIVVESDGESHAL 1923

Human  4229 LMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPG-PQTGPLQELGAGPRPQGPPRL 4292
            ..    .:|:...|.|.....|:: ....|||.........|. |...||.:..:         |
  Fly  1924 TN----SESEDQGQHPQSHHSGSE-DQAAGLLLALAHNNSSPNEPFKSPLSQSHS---------L 1974

Human  4293 PAPPGALSTGPVL-----GPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPK---- 4348
            ||.|.::|:..:|     ||:...|.|:|          .|||.   .|.:.||....|.|
  Fly  1975 PATPASVSSACLLIEAAMGPLQQQPAPAS----------ASPSL---AEFKYPPGGAKTKKSLMS 2026

Human  4349 -----------------------------------PQGPTLEPPPGRVSPAAAQLADTLFSKGLG 4378
                                               |||.:|        ||.|.|....|
  Fly  2027 SWFQQAEQQHASGLDSLVQAAMSEINGEREQLQRQPQGESL--------PAPALLKVEQF----- 2078

Human  4379 PWDPPDNLAETQKPEQSSLVPG----HLD-QVNGQVVPEASQLSIKQE--PREEPCALGAQSVKR 4436
                      ..:.|.::.||.    ||. |.|..|.....:.:|.:|  |.:|......|||..
  Fly  2079 ----------IHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSVTA 2133

Human  4437 EANGEPI----------GAP-----------GTS-----NHLLLAG-PRSEAGHLLLQKLLRAKN 4474
            ..:.:|:          ..|           ||:     .|:.:.| |:.||          .:|
  Fly  2134 TPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEA----------EEN 2188

Human  4475 VQLSTGRGSEGLRAEINGH---IDSKLAGLEQKLQGTPS----------NKED--AAARKPLTPK 4524
            |.::.      |:.||..|   .|..:..|.....||..          ..||  |||.......
  Fly  2189 VAMTE------LKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDV 2247

Human  4525 PKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVN 4589
            .:...:|.|:.....|..|:|:..|..|....|.:||.. .|..|||               ||
  Fly  2248 EREESQACDKFEEMVKVKREEEEQREKEIKQLQERQEHE-QPKVEPA---------------PV- 2295

Human  4590 GQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVN-GVTPSEELGE 4653
             :.:|............|.  .::::|..       |:.:.|.|..|:.:.... ..||:
  Fly  2296 -EPKLENTVAKAEPKVEPS--QEIVSKKE-------PTKVEPKPGESLLRSTATVTATPT----- 2345

Human  4654 HPKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESIL 4718
                  :|..:...|.|.|:|       |..|.|..:.||   |..:.....:||:||.
  Fly  2346 ------AATIAATTLLDVSKV-------AFKTRPPLKLED---EPQKKKPKLESILPAP------ 2388

Human  4719 GEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGS 4783
                                     :..:|..|:|             .:|.....||......:
  Fly  2389 -------------------------VATVPPVSVP-------------PIPAASNATTSAVTNTA 2415

Human  4784 EVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPN-SY---------EVLFPESPARAGTEPKKGEA 4838
            ..|:..|.:.::.|||....:. ..|||....| ||         ..|...||::     |...:
  Fly  2416 AASLTTTTAPSSTKNLTEHDIQ-ERLLSFHAANISYLQSRNKKATAALTSASPSQ-----KSNSS 2474

Human  4839 EGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSN 4903
            .|..|.|.....|..|...|..||                |...|:|....:...:.....||::
  Fly  2475 SGGSGTESKKSSKDKDEKRDKEKQ----------------LKKSKKEKKKSKDKEKQKAAVNVNS 2523

Human  4904 ----LDVRQLSAPPPEEPSPPPSPLAPSPA-SPPTEPL--------------------------- 4936
                :|.::.:.    :||.|.|..:.:|. .||:.|:
  Fly  2524 TSQIVDTKKKTT----QPSKPDSKSSIAPVLVPPSLPVATANGKTKHTAYNNVDQQQQQQMRRRT 2584

Human  4937 VELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQK 5001
            :.:...|:...||.:|.||..:|.|.:   :.:...|.|.::|       ..:.....:||...|
  Fly  2585 MSMCITPVTPTPVVTPSPLHGTPPSTK---KRQTNFEQELTKP-------NSQILSSSILLNSSK 2639

Human  5002 GSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARL 5052
            |.|.......|...         |..|.:...|....|:|...|:.||..|
  Fly  2640 GLGLPLAAPTVVSV---------PTAVQQQQHRKENNHQEATPASGGPMSL 2681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KMT2D	XP_011537072.1	None
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	6/42 (14%)
		SET	<1221..1273	CDD:214614	11/58 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030