Protein Alignment KMT2D and SPCC645.13

DIOPT Version :9

• Sequence 1: XP_011537072.1
• Gene: KMT2D / 8085
• HGNCID: 7133
• Length: 5556
• Species: Homo sapiens
• Sequence 2: NP_001342882.1
• Gene: SPCC645.13 / 2538700
• PomBaseID: SPCC645.13
• Length: 721
• Species: Schizosaccharomyces pombe
• Alignment Length: 582
• Identity: 100/582 - (17%)
• Similarity: 164/582 - (28%)
• Gaps: 214/582 - (36%)

Human  1500 PCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYVVKPV 1564
            |..::|.| :|.:.....|..:||..|:.|.||.|..|..:|     ..|.:.|..|
pombe    16 PPETVVRC-VCKSQEDIGDTWVQCDGCDCWQHASCVGLADKD-----IPESYYCEVC-------- 66

Human  1565 APVAPPELVPMKVKEPEPQYFRFEGVWLTETGMALLRNLTMSPLHKRRQRRGRLGLPGEAGLEGS 1629
                                         .:...:...:..||......:...|....|...:.:
pombe    67 -----------------------------HSRSDVSSQVQNSPNKDEEHQTADLLASNEGNEKNN 102

Human  1630 EPSDALGPDDKKDGDLDTDELLKGEGGVEHMECE----------IKLEGPVSPDVEPGKEETEES 1684
            |.::.:..|.|        |.:..|.|.|....|          ....|..||....|....:.|
pombe   103 EENNVVSSDSK--------EAITKESGAELESSEPASTNSNVGMTTRSGRQSPRTPIGSTTPKSS 159

Human  1685 ----KKRKRKPYRPGIGGFMVRQRKSHTRTKKGP-------AAQAEVLSGDGQPDEGETVIPADL 1738
                ..|||   |..:|......::|....|..|       |.|.:.||.....||.:..:...:
pombe   160 HSPPSTRKR---RGSVGTTATHTKRSKNAPKTSPKDASNETADQEKELSLHTSIDEIQNPVRKSV 221

Human  1739 PA------EGAVEQSLAEG----------------------------------DEKKKQQRRGRK 1763
            ..      |..:|::..||                                  :.|.:::.|..:
pombe   222 AKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLALQLEHIMFMVLSYTTDHSLTPNNKYREKFRALR 286

Human  1764 KSKLEDMFPAY----LQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKE----- 1819
            .:.::|..||:    |:......:|::||            |..:..|..|......|::
pombe   287 FNLVDDKNPAFRARVLKNEISFNDLVNLS------------SEEMANPDLKNLAEEIRQQSTENT 339

Human  1820 -------LPTSQKGDDGPDIADEESRGLEGKADTPGPEDGGVKASPV------PS-DPEKPGTPG 1870
                   .|..:..|: ..:..::..|:....|...|:..|...:|:      |: |.:.|..|.
pombe   340 VIKQHLIAPRDRLLDE-DKLTQQDELGIAENDDAMFPKPPGELVAPISIAEEEPTIDSKSPTLPE 403

Human  1871 EGMLSSDLDRISTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGSRTPLQRPFLQGGLPL 1935
            ...||.| |..:.::..|.:..     |.|.                               .|:
pombe   404 HNPLSED-DTSNGDKAAKRKGS-----FNDT-------------------------------KPI 431

Human  1936 GNLPSSSPMD-------------------SYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTG 1978
            .|:||...:|                   |.|   .||..|..|...||    |..:..|||
pombe   432 VNVPSIVEIDDPTILDIVEEEPLARNDSFSSP---YSPAEDMAEESEFF----GMKEKIWTG 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KMT2D	XP_011537072.1	None
SPCC645.13	NP_001342882.1	PHD_SF	22..66	CDD:328929	14/49 (29%)
		TFS2M	215..330	CDD:128786	16/126 (13%)
		SPOC	474..624	CDD:311609	6/17 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030