DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COL18A1 and col18a1a

DIOPT Version :9

Sequence 1:	NP_569711.2	Gene:	COL18A1 / 80781	HGNCID:	2195	Length:	1751	Species:	Homo sapiens
Sequence 2:	XP_021334395.1	Gene:	col18a1a / 564123	ZFINID:	ZDB-GENE-030516-3	Length:	1645	Species:	Danio rerio

Alignment Length:	1705	Identity:	789/1705 - (46%)
Similarity:	973/1705 - (57%)	Gaps:	196/1705 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   145 LETPVGPLALAGPSSTPQENGTTLWPSRGIPSSPGAHTTEAGTLPAPTPSPPSL-GRPWAPLTGP 208
            ::|| ..|...||:|.|:..     |||...:|  |..||...........|.: .|....:...
Zfish    38 VQTP-AYLTTVGPTSLPRTE-----PSRTTGTS--ASVTEEVAKEVSFEGEPEVRSRSGLGIESG 94

Human   209 SVPPPSSGRASLSSLLGGAPPWGSLQDPDSQGLSPAAAAPSQQLQRPDVRLRTPLLHPLVMGSLG 273
            |....||.......|......||.:.|..|.         ..|:.:.|   :|..|.|
Zfish    95 SGSGSSSFERQHEYLTSSDKIWGIIDDNSSL---------HNQVTKVD---QTDGLDP------- 140

Human   274 KHAAPSAFSSGLPGALSQVAVTTLTRDSGAWVSHVANSVGPGL-------ANNSALLGAD---PE 328
               |.|.|:.|:     .|:.|.:|..:....|:.|......|       ::|:..:.:.   ..
Zfish   141 ---ANSRFNEGV-----NVSFTNITAKNNVNESNFAEHANTTLYSSEYAVSDNALTIESQFLIAS 197

Human   329 APAG----RCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFF 389
            .||.    ||||:...||.|...|:..|.:||.|:..|.|:||.....|..||::.||..|.|||
Zfish   198 MPASFEPLRCLPVDSGLPFCTRRGVESFSVPNFLNQSSVEEVRMVLTEWAWLLRSGCHHSLEWFF 262

Human   390 CLLLVPPCGSVPPPAPPPCCQFCEALQDACWSRLGGGRLPVACASLPTQE-DGYCVLIGPAAERI 453
            ||||.|.||.  ..:..||...||.|||:||:.|..|||||.|.|||.:: |||..|   :...:
Zfish   263 CLLLTPRCGH--SGSLLPCRSSCEVLQDSCWTLLDEGRLPVECKSLPEEKHDGYRCL---SVSNL 322

Human   454 SEE--VGLLQLLGDPPPQQVTQTDDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPA 516
            .||  |.||||:|||||..|::..|......|||||.:|.||.|..|.|:.|:|||||:|:|:|.
Zfish   323 KEESGVSLLQLIGDPPPNGVSKVFDQANSPGYVFGPSSNVGQSAAAHLPNPFYRDFSLIFNIKPT 387

Human   517 TEGPGVLFAITDSAQAMVLLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLA 581
            :..|||:|:|||..|.::.:|||||.|:.|.|.|...||||.:..::.||.|.:.:.:..||..:
Zfish   388 SSKPGVIFSITDPTQNIMYVGVKLSAVERGKQSIIFYYTEPDSQSSYEAARFSVSSMLNIWTRFS 452

Human   582 LSVAGGFVALYVDCE-EFQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQ 645
            :||....|:||.:|: :.|.:...||...::::.|||:||..|.|||||||.|||.:|:|.|||.
Zfish   453 ISVLNEQVSLYFNCDSDPQVVNFERSPDDMDMDAGAGVFVGHASGADPDKFLGVIGDLRVSRDPG 517

Human   646 VSPMHCLDEEGDDSDGASGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSR 710
            .:..||.:||.|.:..||||.|:. ||.      |..:.::|..|:..|:..||:......:...
Zfish   518 AAERHCEEEEDDYATEASGDYGAS-GDG------EQPSPVQPTPPSSRPIQRPPVISRDPIQRPP 575

Human   711 --SEEVEEQTTV----ASLGAQTLPGSDSVSTWDGSVRTPGGRVKEGGLKGQKGEPGVPGPPGRA 769
              |.|..:||..    ...|.:...|...::...|.|.:  |.|..||.||.||.||..|..|.:
Zfish   576 VISREPIQQTVARGEKGDRGEKGAKGDRGLAGPKGDVGS--GSVSGGGSKGDKGVPGEKGMKGTS 638

Human   770 --GPPGSPCLPGPPGLPCPVSPLGPA--------GPALQTVPGPQGPPGPPGRDGTPGRDGEPGD 824
              |.|||....||||.|.|..|.||:        |..:|.|.||:|||||.|..|.||.:|||||
Zfish   639 GFGYPGSKGDRGPPGPPGPPGPQGPSAEVEVRGDGSVVQKVTGPRGPPGPQGPPGPPGPEGEPGD 703

Human   825 PGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDMEGS 889
            ||||||.|..||.||||.||:.||||||||.|..:.||.||.|||||||||...|:.||:|||||
Zfish   704 PGEDGKAGQVGPSGFPGNPGNPGPKGDKGDRGESQPGPRGPPGPPGPPGPSSGFDRPTFVDMEGS 768

Human   890 GFGGDLEALRGPRGFPGPPGPPGVPGLPGEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGP 954
            ||  |::::|...|.||||||||.||.||       ::|...|..|.||.||:.|.||.|||.|.
Zfish   769 GF--DMDSVRAVPGLPGPPGPPGPPGPPG-------SASSGSGGFGPPGPPGQNGAPGQPGLSGV 824

Human   955 PGPPGREGPPGRTGQKGSLGEAGAP---GHKGSKGAPGPAGARGESGLAGAPGPAGPPGPPGPPG 1016
            ||..|:.|.||..|:||..||.|.|   |.||:||:.||.|..|..|.||.|||.||.|.|||||
Zfish   825 PGADGKPGLPGPKGEKGDAGELGLPGPVGEKGAKGSSGPPGTTGIGGPAGLPGPIGPIGLPGPPG 889

Human  1017 PPGPGLPAGFDDMEGSGGPFWST--ARSADGPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVPGF 1079
            ||||....|||||||||..|.|.  .|...|..||||:||.:|.||.|||||.||.:||.   |.
Zfish   890 PPGPSFNVGFDDMEGSGVHFSSVPGVRGPVGIPGPPGVPGPQGQPGFPGLPGEKGSLGAQ---GN 951

Human  1080 PGLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQPGLPGPPGPPGPVVY-VSEQDGSV--LSVP 1141
            .||||.:|..||||||||:|.||::|:||:||.|.||.||||||||.::| .||....|  ....
Zfish   952 DGLPGADGFPGPQGPKGDKGERGDRGEPGRDGHGHPGQPGPPGPPGQIIYRYSEHYDEVGGTGAQ 1016

Human  1142 GPEGRPGFAGFPGPAGPKGNLGSKGERGSPG--PKGEKGEPGSIFSPDGGALG----PAQKGAKG 1200
            |..|.||.||||||.||||:   :||.|.||  .||||||||.|..|||..|.    ..|||.:|
Zfish  1017 GGSGVPGQAGFPGPMGPKGD---RGEPGLPGYDIKGEKGEPGLILGPDGNPLYLGGLTGQKGERG 1078

Human  1201 EPGFRGPPGPYGRPGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGFGMRGMPGPPGPPGPPGP 1265
            ..|..|||||.|.||.|||.|.||||||||:||.|||||||...| |:|..|.|||||||||||
Zfish  1079 ISGPVGPPGPAGPPGAKGEFGMPGRPGRPGVNGYKGEKGEPSSGS-GYGYPGPPGPPGPPGPPG- 1141

Human  1266 PGTPVYDSNVFAESSR--PGPPGLPGNQGPPGPKGAKGEVGPPGPPG-QFPFDFLQLEAEMKGEK 1327
            |..|:.....:.:.:|  |...|..|:||.|         |.||.|| ...||...|:.|||||
Zfish  1142 PAVPLDRFGRYEDYARLYPATKGEKGDQGAP---------GIPGSPGFSTNFDIYSLKNEMKGE- 1196

Human  1328 GDRGDAGQKGERGEPGGGGF---FGSSLPGPPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPG 1389
              ||::|.|||:||||||.:   || ::.||||.|||      .||||:||||.|||.||.|.||
Zfish  1197 --RGESGLKGEKGEPGGGFYDPRFG-AVQGPPGNPGP------AGPKGDSIRGPPGPQGPPGTPG 1252

Human  1390 IGYEGR---QGPPGPPGPPGPPSFPGPHRQTISVPGPPGPPGPPGPPGTMGASSGVRLWATRQAM 1451
            :||:||   .||||||||||.||.|||:|..:|:|||||||||||.|||   .|||.:..:...|
Zfish  1253 VGYDGRPGNPGPPGPPGPPGSPSLPGPYRPPLSIPGPPGPPGPPGIPGT---GSGVTVLRSHDIM 1314

Human  1452 LGQVHEVPEGWLIFVAEQEELYVRVQNGFRKVQLEARTPLPRGTDNEVAALQPPVV----QLHDS 1512
            :.......||.||::.::.:||:||::|.|:|.|....||....||||||:|||.|    |.|.:
Zfish  1315 IATARRQTEGTLIYILDRNDLYLRVRDGVRQVMLGDYKPLYGELDNEVAAVQPPPVVHYSQDHTA 1379

Human  1513 N-------------PYPRRE----HPHPTARPWRADDILASPPRLP-----------EPQ-PYPG 1548
            |             .:|.||    :|:|...|...|      ||.|           ||. .||.
Zfish  1380 NNGAEQISPPHQPIDFPTREQENRNPNPQPDPRYPD------PRYPPYTDNRYTDPVEPNIRYPV 1438

Human  1549 APHHSSYVHLRPARPTSPP-------AHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCFQQAR 1606
            .|..:.   :.|||...||       ||:|.. .|.|||:|||||..|.|||||||||.||||||
Zfish  1439 QPERNP---ITPARRPIPPVNQPGGHAHTHTS-GPGLHLIALNSPQVGNMRGIRGADFMCFQQAR 1499

Human  1607 AVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSF 1671
            |||:.|||||||||:||||||||||:||..:|||||||::||.|||:|||.||..:|..|.|:||
Zfish  1500 AVGMKGTFRAFLSSKLQDLYSIVRRSDRETLPIVNLKDQVLFSSWESLFSDSESRMKDNAPIYSF 1564

Human  1672 DGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLGGRLLGQSAASCHHA 1736
            ||:||||...||:|.:|||||..|.|.|::||||||....:.||.||||..|:||.|:::||..:
Zfish  1565 DGRDVLRDSAWPEKMIWHGSDGRGHRQTDNYCETWRAGDRAVTGLASSLQAGQLLQQTSSSCSSS 1629

Human  1737 YIVLCIENSFMTASK 1751
            |||||||||:||.||
Zfish  1630 YIVLCIENSYMTQSK 1644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COL18A1	NP_569711.2	Collagen	<819..856	CDD:189968	28/36 (78%)
		Collagen	1057..1107	CDD:189968	30/49 (61%)
		Collagen	1141..1181	CDD:189968	25/41 (61%)
		Endostatin-like	1575..1745	CDD:238151	113/169 (67%)
		DUF959	25..194	CDD:283722	14/48 (29%)
		CRD_Collagen_XVIII	330..452	CDD:143564	57/126 (45%)
		TSPN	456..644	CDD:214560	87/190 (46%)
col18a1a	XP_021334395.1	CRD_Collagen_XVIII	203..340	CDD:143564	66/141 (47%)
		LamG	327..516	CDD:328935	86/188 (46%)
		Collagen	816..860	CDD:189968	23/43 (53%)
		Collagen	<937..980	CDD:189968	27/45 (60%)
		Collagen	959..1055	CDD:189968	57/98 (58%)
		Endostatin	1471..1639	CDD:310825	113/167 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332449
Domainoid	1	1.000	292	1.000	Domainoid score	I7758
eggNOG	1	0.900	-	-		E1_KOG3546
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1331	1.000	Inparanoid score	I1287
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG42034
OrthoDB	1	1.010	-	-		D1362001at2759
OrthoFinder	1	1.000	-	-		FOG0002295
OrthoInspector	1	1.000	-	-		otm28629
orthoMCL	1	0.900	-	-		OOG6_106129
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1979
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	14	14.260