DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COL18A1 and Col18a1

DIOPT Version :9

Sequence 1:	NP_569711.2	Gene:	COL18A1 / 80781	HGNCID:	2195	Length:	1751	Species:	Homo sapiens
Sequence 2:	XP_006513236.1	Gene:	Col18a1 / 12822	MGIID:	88451	Length:	1774	Species:	Mus musculus

Alignment Length:	1814	Identity:	1271/1814 - (70%)
Similarity:	1408/1814 - (77%)	Gaps:	108/1814 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAPYPCG--CHILLLLFCCL---AAARANLLN----LNWLWFNNEDTSHAAT-TIPEPQGPLPVQ 55
            |||.|..  |.:||||..|.   |:|..|.|:    |.|||  ...||.:.. .:.:||...|||
Mouse     1 MAPDPSRRLCLLLLLLLSCRLVPASADGNSLSPLNPLVWLW--PPKTSDSLEGPVSKPQNSSPVQ 63

Human    56 PTADTTTHVTPRNGSTEPATAPGSPE-PPSELLEDGQD--------TP-------TSAESPDAPE 104
            .|.:.||||.|::|.||..|.|.|.| ||.|..|:.|.        ||       ..|.|||..|
Mouse    64 STENPTTHVVPQDGLTEQQTTPASSELPPEEEEEEDQKAGQGGSPATPAVPIPLVAPAASPDMKE 128

Human   105 ENIAGVGAEILNVAKGIRSFVQLWND----------TVPTESLARAETLVLETPVGPLALAGP-- 157
            ||:|||||:|||||:|||||||||::          .||..|:             |..|..|
Mouse   129 ENVAGVGAKILNVAQGIRSFVQLWDEDSTIGHSAGTEVPDSSI-------------PTVLPSPAE 180

Human   158 -SSTPQENGTTLWPSRGIPSSPGAHTTEAGTLPAPTPSPPSLGRPWAPLTGPSVPPPSSGRASLS 221
             ||.||.:.||||.|..|||||.|.|||||||..||..||......|||..||.||...|||.||
Mouse   181 LSSAPQGSKTTLWLSSAIPSSPDAQTTEAGTLAVPTQLPPFQSNLQAPLGRPSAPPDFPGRAFLS 245

Human   222 SLLGGAPPWGSLQDP------DSQGLSPAAAAPSQQLQRPDVRL----RTPLL----HPLVMGSL 272
            |....|||||:.:.|      :.:|..|..|..|||.:..||..    ..|||    .|||..||
Mouse   246 SPRIRAPPWGNQEPPRQPQHLEGKGFLPMTARSSQQHRHSDVHSDIHGHVPLLPLVTGPLVTASL 310

Human   273 GKHAAPSAFSSGLPGALSQVAVTTLTRDSGAWVSHVANSVGPGLANNSALLGADPEAPAGRCLPL 337
            ..|...|..||...|.|||||  .|....|.||||||.|.|.||:|:|||.|........|||||
Mouse   311 SVHGLLSVPSSDPSGQLSQVA--ALPGFPGTWVSHVAPSSGTGLSNDSALAGNGSLTSTSRCLPL 373

Human   338 PPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLLVPPCGSVPP 402
            ||:|.:|..|||..|||||||||....:|.|..:|||..|.|:|||||||||||||.|.||..||
Mouse   374 PPTLTLCSRLGIGHFWLPNHLHHTDSVEVEATVQAWGRFLHTNCHPFLAWFFCLLLAPSCGPGPP 438

Human   403 PAPPPCCQFCEALQDACWSRLGGGRLPVACASLPTQEDGYCVLIGPAAERISEEVGLLQLLGDPP 467
            |..|||.||||||:|.||:.|.|.||||.|||||:|||||||.||||||.::||||||||||||.
Mouse   439 PPLPPCRQFCEALEDECWNYLAGDRLPVVCASLPSQEDGYCVFIGPAAENVAEEVGLLQLLGDPL 503

Human   468 PQQVTQTDDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPATEGPGVLFAITDSAQA 532
            |::::|.|||.||.||:||||:||||||:||||.|||||||||||:|||||..||||||||:||.
Mouse   504 PEKISQIDDPHVGPAYIFGPDSNSGQVAQYHFPKLFFRDFSLLFHVRPATEAAGVLFAITDAAQV 568

Human   533 MVLLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVDCEE 597
            :|.||||||.|:||.|:||||||||||.||.|.||||||||||||||.||||.||.|||||||||
Mouse   569 VVSLGVKLSEVRDGQQNISLLYTEPGASQTQTGASFRLPAFVGQWTHFALSVDGGSVALYVDCEE 633

Human   598 FQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDEEGDDSDGA 662
            |||:|.||:|:|||||.||||||.|||.||||||||:|:|||||:.|:|||:||||||.||.|.|
Mouse   634 FQRVPFARASQGLELERGAGLFVGQAGTADPDKFQGMISELKVRKTPRVSPVHCLDEEDDDEDRA 698

Human   663 SGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSRSEEVEEQTTVASLGAQT 727
            |||.|||..::.:..:|:|  :|.|.||.|||||:|||||||:|||.|:||.||...|.|:||:|
Mouse   699 SGDFGSGFEESSKSHKEDT--SLLPGLPQPPPVTSPPLAGGSTTEDPRTEETEEDAAVDSIGAET 761

Human   728 LPGSDSVSTWDGSVRTPGGRVKEGGLKGQKGEPGVPGPPGRAGPPGSPCLPGPPGLPCPVSPLGP 792
            |||:.|...||.:::.||..:.:||:||||||||..||||.|||.                  ||
Mouse   762 LPGTGSSGAWDEAIQNPGRGLIKGGMKGQKGEPGAQGPPGPAGPQ------------------GP 808

Human   793 AGPALQT-----VPGPQGPP---GPPGRDGTPGRDGEPGDPGEDGKPGDTGPQGFPGTPGDVGPK 849
            |||.:|:     |||.||||   ||||:|||||||||||||||||:|||||||||||||||||||
Mouse   809 AGPVVQSPNSQPVPGAQGPPGPQGPPGKDGTPGRDGEPGDPGEDGRPGDTGPQGFPGTPGDVGPK 873

Human   850 GDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDLEALRGPRGFPGPPGPPGVP 914
            |:|||||:|.||||   |||||||||||.|||||||||||||.||:|:|||||||||||||||||
Mouse   874 GEKGDPGIGPRGPP---GPPGPPGPSFRQDKLTFIDMEGSGFSGDIESLRGPRGFPGPPGPPGVP 935

Human   915 GLPGEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGPPGREGPPGRTGQKGSLGEAGAP 979
            ||||||||||:|.|..|||||||||||:||||||||.||||||||:|||||..|||||:|:.|.|
Mouse   936 GLPGEPGRFGINGSYAPGPAGLPGVPGKEGPPGFPGPPGPPGPPGKEGPPGVAGQKGSVGDVGIP 1000

Human   980 GHKGSKGAPGPAGARGESGLAGAPGPAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTARSAD 1044
            |.|||||..||.|..|:|||||:|||.|||||||||||||||..||||||||||.|.|:||||:|
Mouse  1001 GPKGSKGDLGPIGMPGKSGLAGSPGPVGPPGPPGPPGPPGPGFAAGFDDMEGSGIPLWTTARSSD 1065

Human  1045 GPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVPGFPGLPGREGIAGPQGPKGDRGSRGEKGDPGK 1109
            |.|||||.|||||||||.|||||||||||||..|.||.|||||.||..||||::|..||||:|||
Mouse  1066 GLQGPPGSPGLKGDPGVAGLPGAKGEVGADGAQGIPGPPGREGAAGSPGPKGEKGMPGEKGNPGK 1130

Human  1110 DGVGQPGLPGPPGPPGPVVYVSEQDGSVLSVPGPEGRPGFAGFPGPAGPKGNLGSKGERGSPGPK 1174
            ||||:|||||||||||||:|||.:|.:::|.|||||:||:|||||||||||:||||||:|.||||
Mouse  1131 DGVGRPGLPGPPGPPGPVIYVSSEDKAIVSTPGPEGKPGYAGFPGPAGPKGDLGSKGEQGLPGPK 1195

Human  1175 GEKGEPGSIFSPDGGALGPAQKGAKGEPGFRGPPGPYGRPGYKGEIGFPGRPGRPGMNGLKGEKG 1239
            |||||||:||||||.|||..|||||||||||||||||||||:||||||||||||||.||||||||
Mouse  1196 GEKGEPGTIFSPDGRALGHPQKGAKGEPGFRGPPGPYGRPGHKGEIGFPGRPGRPGTNGLKGEKG 1260

Human  1240 EPGDASLGFGMRGMPGPPGPPGPPGPPGTPVYDSNVFAESSRPGPPGLPGNQGPPGPKGAKGEVG 1304
            |||||||||.|||:||||||||||||||.|:||||.|.||.|||.||..|.|||.||||.|||||
Mouse  1261 EPGDASLGFSMRGLPGPPGPPGPPGPPGMPIYDSNAFVESGRPGLPGQQGVQGPSGPKGDKGEVG 1325

Human  1305 PPGPPGQFPFDFLQLEAEMKGEKGDRGDAGQKGERGEPG--GGGFFGSSLPGPPGPPGPRGYPGI 1367
            |||||||||.|...|||||||:|||||||||||||||||  |||||.||:|||||||   |||||
Mouse  1326 PPGPPGQFPIDLFHLEAEMKGDKGDRGDAGQKGERGEPGAPGGGFFSSSVPGPPGPP---GYPGI 1387

Human  1368 PGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTISVPGPPGPPGPPGP 1432
            ||||||||||.|||||||||||||||||||||||||||||||||||||||:||||||||||||||
Mouse  1388 PGPKGESIRGPPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTVSVPGPPGPPGPPGP 1452

Human  1433 PGTMGASSG-VRLWATRQAMLGQVHEVPEGWLIFVAEQEELYVRVQNGFRKVQLEARTPLPRGTD 1496
            ||.||||:| ||:|||.|.||.::.||||||||||||:|||||||:||||||.|||||.|||||.
Mouse  1453 PGAMGASAGQVRIWATYQTMLDKIREVPEGWLIFVAEREELYVRVRNGFRKVLLEARTALPRGTG 1517

Human  1497 NEVAALQPPVVQLHDSNPYPRREHPHPTARPWRADDILASPPRLPEPQPYPGAP-HHSSYVHLRP 1560
            |||||||||:||||:.:||.|||:.:.||||||||||||:|||||:.|||||.| ||||||||.|
Mouse  1518 NEVAALQPPLVQLHEGSPYTRREYSYSTARPWRADDILANPPRLPDRQPYPGVPHHHSSYVHLPP 1582

Human  1561 ARPTSPPAHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQDL 1625
            ||||...||:|:||||||||||||:|||||||||||||||||||||||||:||||||||||||||
Mouse  1583 ARPTLSLAHTHQDFQPVLHLVALNTPLSGGMRGIRGADFQCFQQARAVGLSGTFRAFLSSRLQDL 1647

Human  1626 YSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPLKPGARIFSFDGKDVLRHPTWPQKSVWHG 1690
            |||||||||.:|||||||||:|.|||::|||||:|.|:||||||||||:||||||.|||||||||
Mouse  1648 YSIVRRADRGSVPIVNLKDEVLSPSWDSLFSGSQGQLQPGARIFSFDGRDVLRHPAWPQKSVWHG 1712

Human  1691 SDPNGRRLTESYCETWRTEAPSATGQASSLLGGRLLGQSAASCHHAYIVLCIENSFMTA 1749
            |||:||||.||||||||||...|||||||||.||||.|.|||||::||||||||||||:
Mouse  1713 SDPSGRRLMESYCETWRTETTGATGQASSLLSGRLLEQKAASCHNSYIVLCIENSFMTS 1771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COL18A1	NP_569711.2	Collagen	<819..856	CDD:189968	34/36 (94%)
		Collagen	1057..1107	CDD:189968	37/49 (76%)
		Collagen	1141..1181	CDD:189968	34/39 (87%)
		Endostatin-like	1575..1745	CDD:238151	146/169 (86%)
		DUF959	25..194	CDD:283722	88/202 (44%)
		CRD_Collagen_XVIII	330..452	CDD:143564	82/121 (68%)
		TSPN	456..644	CDD:214560	148/187 (79%)
Col18a1	XP_006513236.1	DUF959	37..218	CDD:368758	87/195 (45%)
		CRD_Collagen_XVIII	366..488	CDD:143564	82/121 (68%)
		TSPN	492..680	CDD:214560	148/187 (79%)
		Collagen	<840..875	CDD:189968	33/34 (97%)
		Collagen	1069..1128	CDD:189968	45/58 (78%)
		Collagen	1108..1197	CDD:189968	66/88 (75%)
		Collagen	1172..1265	CDD:189968	83/92 (90%)
		Endostatin	1463..1765	CDD:368935	246/301 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83962095
Domainoid	1	1.000	526	1.000	Domainoid score	I6808
eggNOG	1	0.900	-	-		E1_KOG3546
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7673
Inparanoid	1	1.050	2568	1.000	Inparanoid score	I878
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42034
OrthoDB	1	1.010	-	-		D1362001at2759
OrthoFinder	1	1.000	-	-		FOG0002295
OrthoInspector	1	1.000	-	-		oto125733
orthoMCL	1	0.900	-	-		OOG6_106129
Panther	1	1.100	-	-	LDO	PTHR24023
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1979
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270