DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF34 and Zfp991

DIOPT Version :9

Sequence 1:	NP_085057.3	Gene:	ZNF34 / 80778	HGNCID:	13098	Length:	560	Species:	Homo sapiens
Sequence 2:	NP_001077387.1	Gene:	Zfp991 / 666532	MGIID:	3701604	Length:	573	Species:	Mus musculus

Alignment Length:	551	Identity:	235/551 - (42%)
Similarity:	316/551 - (57%)	Gaps:	39/551 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    31 PQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVMLETYGNLVSL-GVGPAGPKPGVISQLERGDE 94
            ||..:||:|||:..|.|||..|..|||.||.|||||.|.||:.: .....|....|:.|    |.
Mouse     9 PQGLLTFKDVALDFSLEEWESLSFAQRTLYMDVMLENYNNLLFVENHCICGKYEKVLDQ----DS 69

Human    95 PWV----LDVQGTSGK----EHLRVNSPALGTRTEYKELTSQETFGEEDPQGSEP---VEACDHI 148
            .::    :::|..|.|    .::.:.:|..   |.||...:.:.....:.:..:|   .|.|.:
Mouse    70 QYIVHEHMNIQEKSSKWDKLSNVILEAPQC---TPYKTNHTSDALQFSNQKRLKPRNTKEVCKY- 130

Human   149 SKSEGSLEKLVEQRGPRAVTLTNG--ESSRESGGNLR-----------LLSRPVPDQRPHKCDIC 200
            :.|..||...      ..::|..|  ...::..||..           ::.|......|:||...
Mouse   131 NDSVNSLTLF------STISLNQGIHMQKKKHNGNAESEKAFISKHKVMVKRNNTGVNPYKCSKF 189

Human   201 EQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSAN 265
            ::...||..|.:.:|::..||......|.:.|:..:.:...|.|...:|::.||.|.|.|.:..:
Mouse   190 DKYLTQRDKLQSQQRIYHEKKHYRSSKSDKCFTHQIDLSIHQGIHAEEKIYKCSECDKCFTHKFH 254

Human   266 LVKHQRLHTEEKPYKCDECGKAFSQSCEFINHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHT 330
            |..|||:||.||||||.||.|.|:|......|:|:|:||.||:|..|.|.||.:.||..||||||
Mouse   255 LNIHQRIHTGEKPYKCSECDKCFTQKSHLNIHQRIHTGEKPYKCIVCEKCFTEKGNLRIHQRIHT 319

Human   331 GEKPYKCGECGKHFSAYSSLIYHQRIHTGEKPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKE 395
            |:|||||.||.|.|:..|.|..|||||||||||||:.|.|:|::...|..|:|.||||||::|..
Mouse   320 GDKPYKCSECDKCFTQKSHLNIHQRIHTGEKPYKCSQCDKSFTENGHLRIHQRNHTGEKPYKCSR 384

Human   396 CGKGFTQSSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQST 460
            |.|.||::.:|..|||||||||||||:||:|.|.:|..|..|||.|||||||:|::|.|.|:...
Mouse   385 CDKSFTENGHLRIHQRIHTGEKPYKCSECDKCFTKKFSLRIHQRIHTGEKPYKCSECDKCFTFKG 449

Human   461 HLIQHQRIHTGEKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIH 525
            .|..||||||||||||||||.|:|..:..|..|||:|.|||||:|::|.|.|:....|..|:|||
Mouse   450 SLRIHQRIHTGEKPYKCSECDKSFTENGCLRIHQRIHTGEKPYKCTECDKCFTFKGSLRIHQRIH 514

Human   526 TGEKPYKCSECGKAFRHSSNMCQHQRIHLRE 556
            ||||||||:||.|:|.....:..|||||..|
Mouse   515 TGEKPYKCTECDKSFTEKGKLRIHQRIHKGE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF34	NP_085057.3	KRAB	35..97	CDD:214630	27/62 (44%)
		KRAB	35..74	CDD:279668	23/38 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..188		4/37 (11%)
		COG5048	188..554	CDD:227381	186/365 (51%)
		C2H2 Zn finger	197..217	CDD:275368	5/19 (26%)
		zf-C2H2	251..273	CDD:278523	9/21 (43%)
		C2H2 Zn finger	253..273	CDD:275368	9/19 (47%)
		zf-H2C2_2	265..290	CDD:290200	16/24 (67%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		zf-C2H2	307..329	CDD:278523	11/21 (52%)
		C2H2 Zn finger	309..329	CDD:275368	10/19 (53%)
		zf-H2C2_2	321..345	CDD:290200	17/23 (74%)
		C2H2 Zn finger	337..357	CDD:275368	10/19 (53%)
		zf-H2C2_2	349..373	CDD:290200	16/23 (70%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		zf-H2C2_2	378..402	CDD:290200	13/23 (57%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		zf-H2C2_2	405..430	CDD:290200	18/24 (75%)
		C2H2 Zn finger	421..441	CDD:275368	10/19 (53%)
		zf-H2C2_2	434..458	CDD:290200	15/23 (65%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		zf-H2C2_2	461..486	CDD:290200	19/24 (79%)
		C2H2 Zn finger	477..497	CDD:275368	10/19 (53%)
		zf-H2C2_2	493..514	CDD:290200	13/20 (65%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		zf-H2C2_2	517..542	CDD:290200	17/24 (71%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
Zfp991	NP_001077387.1	KRAB	12..52	CDD:396083	23/39 (59%)
		C2H2 Zn finger	186..206	CDD:275368	5/19 (26%)
		C2H2 Zn finger	218..234	CDD:275368	2/15 (13%)
		C2H2 Zn finger	242..262	CDD:275368	9/19 (47%)
		COG5048	266..>550	CDD:227381	162/280 (58%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)
		C2H2 Zn finger	298..318	CDD:275368	10/19 (53%)
		C2H2 Zn finger	326..346	CDD:275368	10/19 (53%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		C2H2 Zn finger	382..402	CDD:275368	9/19 (47%)
		C2H2 Zn finger	410..430	CDD:275368	10/19 (53%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		C2H2 Zn finger	466..486	CDD:275368	10/19 (53%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275368	8/19 (42%)
		C2H2 Zn finger	550..566	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83973331
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840