Protein Alignment TTYH3 and CG3638

DIOPT Version :10

• Sequence 1: NP_079526.1
• Gene: TTYH3 / 80727
• HGNCID: 22222
• Length: 523
• Species: Homo sapiens
• Sequence 2: NP_726720.3
• Gene: CG3638 / 31071
• FlyBaseID: FBgn0261444
• Length: 1472
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 140/612 - (22%)
• Similarity: 241/612 - (39%)
• Gaps: 153/612 - (25%)

Human    12 VSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSE 76
            |.:||.:||.:.::...:..|.|:...|.::|::|.:.....|...||.||.|....||.||:.:
  Fly     8 VKILHSIPHVNYTFRRVNDTFNPDSDVYLESLVILASIPAGLLIGSLLGLLLYLLTRCCDRRQRK 72

Human    77 EHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAV 141
            .....   |.:..::|.||:..|.|.:|.|||.:..:|:.:|..|    .::|.|:       .:
  Fly    73 PSAQR---CQSCSLVIITLMTCAAIGLGLYGNDDFHNGLLQAFGS----GKSVEGL-------VL 123

Human   142 GLNHTAEPSLQTLERQLAG--------RP-----------EPLRAV----QRLQGLLETLLGYTA 183
            .|....|.....||.::||        :|           |..|.|    .|....|::::.|..
  Fly   124 TLKRQTESIKHDLETRMAGHKVEQLVEKPHYNQTVVMLLIETSRLVTENTSRAVASLDSMVHYFM 188

Human   184 AIPFWRNTAVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGVCLLGVL 248
            ......|. .||..|.:..:.|:..||...|..|.:.:::|.::::|:.|.|:..|:...:.|:.
  Fly   189 KAKGSEND-TSLMGLLQLGEFYESIRWPATLAFLTVLLLLCTVLVIGVARRSRCTLIFFSVSGLF 252

Human   249 ALVISWGALGLELAVSVGSSDFCVDPDAYVTKMVEEYSVLSGDILQY--YLAC-SPRAANPFQQK 310
            .::|.|...|:.||.||.:.|||:.|..|:.:.|       |....|  :|.| :||  |.|..:
  Fly   253 CIIICWLLAGVYLASSVAAGDFCMRPHDYMCRQV-------GMRSPYVDFLNCGTPR--NRFILR 308

Human   311 LSGSHKALVEMQDVVAELLRTVPWEQPATKD--PLLRVQEVLNG----TEVNLQHLTAL---VDC 366
            |:       |.:|:|.....:|...|..:::  |.:.:|..||.    .|:.|::||.|   :|.
  Fly   309 LN-------ESRDLVDRARESVEHMQRMSQETYPHIDIQRTLNAMDNDLEITLRNLTTLSATLDR 366

Human   367 RSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSVPHTW--QQKRGPDEDGEEEAAP 429
            |::.:.|.:||.|.|..|:.||..:.:...:|:.:.:.:|.:..|.|  ..||...:..:.|.||
  Fly   367 RTIDMHYEEALRGLCGGGLLGLSLMMVAGLLTSFLLTILVYADSHAWIYLTKRPTLDADKSETAP 431

Human   430 ---------------GP-------------RQA--------------------------HDSL-- 438
                           .|             :||                          |:.:
  Fly   432 LFPASNAPSASISPTAPLSTGTINRTLLHHQQASSGGGSGTLPGSGGGAGAGGGVGANGHNGVGP 496

Human   439 YRVHMPSLYSCGSSYGSETSIPAAAHTVSNAPVT---------------EYMSQNANFQNPRCEN 488
            ||.....|....:|..|::|..::..|.:|...:               .|...|.::.|.:...
  Fly   497 YRNGSAGLRQGLASPSSQSSHTSSTATYNNGTTSYHNSHQQHNNHLYSNHYSHSNNHYNNTQHRT 561

Human   489 TPLIG--------------RESPPPSY 501
            .|..|              ..||||.|
  Fly   562 NPAAGAVAAAVGVVSSGQRSPSPPPVY 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTYH3	NP_079526.1	Tweety	8..435	CDD:461475	121/513 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..435		9/77 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..523		8/34 (24%)
		PY-motif, mediates interaction with NEDD4L. /evidence=ECO:0000250|UniProtKB:Q9BSA4	498..501		2/2 (100%)
CG3638	NP_726720.3	Tweety	4..438	CDD:461475	118/460 (26%)