DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PBX4 and hth

DIOPT Version :9

Sequence 1:	XP_011526622.1	Gene:	PBX4 / 80714	HGNCID:	13403	Length:	391	Species:	Homo sapiens
Sequence 2:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster

Alignment Length:	156	Identity:	48/156 - (30%)
Similarity:	62/156 - (39%)	Gaps:	52/156 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   228 RRKRRNFSKQATEVLNEYFYSHLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKKNMGKF 292
            ::||..|.|.||.:|..:.:.||.:|||||:.|::||:..||||.||:|||.|.|.|..:.|..
  Fly   366 QKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMID- 429

Human   293 QEEATIYTGKTAVDTTEVGVPGNHASCLSTPSSGSSGPFPLPSAGDAFLTLRTLASLQPPPGGGC 357
            |....:|                      ||..|.||     ...||.              |..
  Fly   430 QSNRAVY----------------------TPHPGPSG-----YGHDAM--------------GYM 453

Human   358 LQSQAQGSWQGATPQPATASPAGDPG 383
            :.|||.          ....|.||||
  Fly   454 MDSQAH----------MMHRPPGDPG 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PBX4	XP_011526622.1	PBC	18..226	CDD:281746
PBX4	XP_011526622.1	homeodomain	228..289	CDD:238039	29/60 (48%)
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	21/38 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840