Protein Alignment PBX4 and Six4

DIOPT Version :10

• Sequence 1: XP_011526622.1
• Gene: PBX4 / 80714
• HGNCID: 13403
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 199
• Identity: 50/199 - (25%)
• Similarity: 81/199 - (40%)
• Gaps: 28/199 - (14%)

Human    93 PPDAQLLRLDNMLLAEGVCRPEKRGRGGAVARAGTATPGGCPND-NSIEHSDYRAK------LSQ 150
            |.||::|:.....:.   |..|...:.|.:.:..|......|:: .....|..||:      |.|
  Fly   173 PIDAKMLQFSTDQIQ---CMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAYNLGQ 234

Human   151 IRQIYHSELEKYEQACREFTTHVTNLLQEQSRMRPVSPKEIERMVGAIHGKFSAIQMQLKQSTCE 215
            ..::|:    ..|..|.....||    ..|:.......||.|::.|...|.....:::.|....:
  Fly   235 FHELYN----LLETHCFSIKYHV----DLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPK 291

Human   216 AVMTLRSRLLDARRKRRNFSKQATEVLNEYFYSHLNNPYPSEEAKEELARKGGLTISQVSNWFGN 280
            .:......:...:.|.||..|..          :|.|.||:.:.|:.||:|.|||::||||||.|
  Fly   292 TIWDGEETVYCFKEKSRNALKDC----------YLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKN 346

Human   281 KRIR 284
            :|.|
  Fly   347 RRQR 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PBX4	XP_011526622.1	PBC	18..226	CDD:461052	26/139 (19%)
		homeodomain	228..289	CDD:238039	24/57 (42%)
Six4	NP_649256.1	SIX1_SD	181..290	CDD:465293	22/119 (18%)
		homeodomain	301..355	CDD:238039	24/60 (40%)