DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD276 and dpr21

DIOPT Version :9

Sequence 1:	NP_001019907.1	Gene:	CD276 / 80381	HGNCID:	19137	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_001163838.2	Gene:	dpr21 / 8674044	FlyBaseID:	FBgn0260995	Length:	282	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	64/312 - (20%)
Similarity:	106/312 - (33%)	Gaps:	91/312 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   221 LVRNPVLQQDAHSSVTITP---------------QRSP---TGAVEVQVPEDPVVALVGTDATLR 267
            |:......|....:||:|.               .|.|   |.|.:      .|.:|||....|.
  Fly    14 LILKETCPQHFRENVTVTDLYLISENIVPMKRVLDRGPYFDTSATK------NVTSLVGITGHLN 72

Human   268 CSFSPEPGFSLAQLNLIW-------QLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASL 325
            |...     :|....:.|       .||.::.   ::|..:...|.|..:|         |:.||
  Fly    73 CRIK-----NLGNKTVSWIRHRDLHLLTVSES---TYTSDQRFTSIYNKQT---------GDWSL 120

Human   326 RLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITC-SSYRGY 389
            :::..::.|.|.:.|.||........:...|..|.:  |:...|...:..|.||.:|| ..:...
  Fly   121 QIKFPQLRDSGIYECQVSTTPPVGYTMVFSVVEPIT--SILGGPEIYIDLGSTVNLTCVIKHLPD 183

Human   390 PEAEVFWQDGQ----------GVPL---TGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVR 441
            |...|.|....          ||.:   .|::|||.:.          :.|..:..:|.|:||..
  Fly   184 PPISVQWNHNNQEINYDSPRGGVSVITEKGDITTSYLL----------IQRASIADSGQYTCLPS 238

Human   442 NP--------VLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALA 485
            |.        :|:.|         .|.......|.|:..||:|.:.:.:.|:
  Fly   239 NANSKSVNVHILKGD---------HPAAVQKSHLLVSELLSLCFLQICLNLS 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD276	NP_001019907.1	IG_like	37..138	CDD:214653
		Ig	43..139	CDD:299845
		Ig	148..231	CDD:299845	2/9 (22%)
		IG_like	156..237	CDD:214653	3/15 (20%)
		IG_like	255..356	CDD:214653	22/107 (21%)
		Ig	261..357	CDD:299845	19/102 (19%)
		Ig	366..449	CDD:299845	22/104 (21%)
		IG_like	374..456	CDD:214653	22/103 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..534
dpr21	NP_001163838.2	Ig	71..149	CDD:299845	18/94 (19%)
		IG_like	71..140	CDD:214653	18/85 (21%)
		IG_like	162..249	CDD:214653	21/96 (22%)
		IGc2	169..242	CDD:197706	20/82 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910