DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD276 and dpr6

DIOPT Version :9

Sequence 1:	NP_001019907.1	Gene:	CD276 / 80381	HGNCID:	19137	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	79/335 - (23%)
Similarity:	127/335 - (37%)	Gaps:	105/335 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   207 ILRVVLGANGTYSCLVRNPVLQQDAHSS----VTITP---------QRSPTGA----------VE 248
            :|.||:..:...:..|:.|:   :.::|    :|.||         ..:||.|          .:
  Fly    15 LLLVVIVMSDMTNGGVQGPI---EGYNSLDDLLTTTPTPGQAALLLPTAPTAAYTHPKWMEPYFD 76

Human   249 VQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIW-QLTDTKQL-VHSFTEGRDQ--GSAYAN 309
            ...|.: |.||:|..|.|.|...     :||...:.| :..|...| |.|:|...||  .:.:..
  Fly    77 PSTPRN-VTALMGKSAYLSCRVR-----NLANKTVSWIRHRDIHILTVGSYTYTSDQRFQATHHQ 135

Human   310 RTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLR 374
            .|.         :.:|:::..:..|.|.:.|.:|.:...|..|.|.|..    |:.|:....||.
  Fly   136 DTE---------DWTLQIKWAQKRDAGMYECQISTQPVRSYFVRLNVVV----PTATILGGPDLH 187

Human   375 --PGDTVTITCS-SYRGYPEAEVFWQDGQ----------GVPL---TGNVTTSQMANEQGLFDVH 423
              .|.|:.:||: .:...|.|.:||...:          ||.:   .|:||||.:.
  Fly   188 VDKGSTINLTCTVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDVTTSFLL--------- 243

Human   424 SVLRVVLGANGTYSCL--------VRNPVLQQDAHGSVTITGQPMTFPPEAL----------WVT 470
             :....|..:|.|||.        ||..||...|    .|:|:    .|||:          |:|
  Fly   244 -IQNADLADSGKYSCAPSNADVASVRVHVLNVRA----IISGE----HPEAMQTGSSGCQYNWLT 299

Human   471 V----GLSVC 476
            :    ||.:|
  Fly   300 IVLLLGLVLC 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD276	NP_001019907.1	IG_like	37..138	CDD:214653
		Ig	43..139	CDD:299845
		Ig	148..231	CDD:299845	5/23 (22%)
		IG_like	156..237	CDD:214653	6/33 (18%)
		IG_like	255..356	CDD:214653	26/104 (25%)
		Ig	261..357	CDD:299845	23/99 (23%)
		Ig	366..449	CDD:299845	27/106 (25%)
		IG_like	374..456	CDD:214653	25/105 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..534
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	27/109 (25%)
		IG_like	80..175	CDD:214653	28/109 (26%)
		IG_like	184..271	CDD:214653	24/96 (25%)
		IGc2	191..262	CDD:197706	20/80 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910