DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD276 and hbs

DIOPT Version :9

Sequence 1:	NP_001019907.1	Gene:	CD276 / 80381	HGNCID:	19137	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	73/320 - (22%)
Similarity:	130/320 - (40%)	Gaps:	46/320 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   132 AAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEV-FWQDGQGVPLTGNVTTSQM 195
            |..:|.|..|.....:::.| |:|.||....:.|.|....|.|:: :|:|  |:|:.|    ..:
  Fly   533 ATKTLGVHFPPETVKISVVP-KNLVPGIRAKLICDSSSSNPPAKISWWKD--GIPVEG----LNL 590

Human   196 ANEQGLF-----DVHSILRVVLGANG-TYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPED 254
            ||..||:     .:...:.:....:| .|:|...|.|||:..|.::::.....|    :.:.|:.
  Fly   591 ANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPP----KFETPQS 651

Human   255 PVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLA 319
              ...||.:.   ..|..|            .|.....:|.::|..:| |...::.:.....|::
  Fly   652 --TTFVGVEG---APFHVE------------LLASGNPMVITYTWTKD-GLPISSNSLSGQRLIS 698

Human   320 QGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCS 384
            .| ..|.:.|:...|.|.:.| .::...|:|.:.:|||..|:.....:...:....|:...:.|.
  Fly   699 DG-PRLNISRLSRNDAGVYIC-EALNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACH 761

Human   385 -SYRGYPEAEVFW-QDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRN 442
             ..|....|.|.| :||..:   ...|.|...|...|..:.||.|..:   |.::|:|.|
  Fly   762 IQARPLEAAHVRWSRDGYDL---ATRTISSFENGTALLQIASVERSDI---GNFTCIVDN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD276	NP_001019907.1	IG_like	37..138	CDD:214653	2/5 (40%)
		Ig	43..139	CDD:299845	2/6 (33%)
		Ig	148..231	CDD:299845	25/89 (28%)
		IG_like	156..237	CDD:214653	23/87 (26%)
		IG_like	255..356	CDD:214653	18/100 (18%)
		Ig	261..357	CDD:299845	18/95 (19%)
		Ig	366..449	CDD:299845	19/79 (24%)
		IG_like	374..456	CDD:214653	19/71 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..534
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653
		Ig	266..327	CDD:299845
		IG_like	357..>414	CDD:214653
		Ig	360..427	CDD:299845
		Ig	<468..526	CDD:299845
		I-set	547..633	CDD:254352	25/92 (27%)
		Ig	556..631	CDD:299845	22/80 (28%)
		I-set	644..735	CDD:254352	22/114 (19%)
		IGc2	668..725	CDD:197706	11/59 (19%)
		IG_like	751..829	CDD:214653	19/71 (27%)
		IGc2	753..815	CDD:197706	18/67 (27%)
		Ig	852..928	CDD:143165
		FN3	935..1017	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910