DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CD276 and dpr13

DIOPT Version :9

Sequence 1:	NP_001019907.1	Gene:	CD276 / 80381	HGNCID:	19137	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	69/347 - (19%)
Similarity:	124/347 - (35%)	Gaps:	67/347 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   130 GSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQ 194
            |...|:..:..|.|:||:. ..|::|                    :..|..:|.|:......:|
  Fly    48 GGKTVAATMTTPASEPSVR-HINQNL--------------------IMSQSKEGEPVPVPQPYAQ 91

Human   195 MANEQGLFDVHSI--LRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPV- 256
            .|...|...:.|.  ..|:.|.:......::..|||..:||.:.......|. .:.|..|| ||
  Fly    92 SAASAGGSSITSFDSTNVIDGQSQPTPTHLQEAVLQTHSHSRIQAKDTAGPY-PIPVHRPE-PVE 154

Human   257 ---VALVGTDATLRCSFSPEPGFSLAQLNLI-WQLTDTKQL---VHSFTEG-------RDQGSAY 307
               .|..|.:..:...|.....|......:: .|:..|..:   ||...||       :|.....
  Fly   155 NHLEANNGIEGGMESLFGTPMYFGTENSTVVTTQIGATAHVPCTVHHIGEGVVSWIRKKDYHLLT 219

Human   308 ANRTALFPD-------LLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSM 365
            ...|....|       |....:.:|:::.|::.|.|.:.|.||...  ..::.|.::...::..:
  Fly   220 VGLTTYSSDERFSATHLKHSEDWTLQIKFVQLRDAGVYECQVSTHP--PTSIFLHLSVVEARAEI 282

Human   366 TLEPNKDLRPGDTVTITCSSYRGYPEAE-VFWQD---------GQGVPLTGNVTTSQMANEQGLF 420
            |..|.:.|.||.|:.:.|...:....:| :||..         .:|:    ||:|........|
  Fly   283 TGPPIRYLTPGSTLRLQCRVVQNTEASEYIFWYHDNRMINYDIDRGI----NVSTEPDFQSSEL- 342

Human   421 DVHSVLRVVLGANGTYSCLVRN 442
               ::.|.....:|.::|:..|
  Fly   343 ---TIQRTRREHSGNFTCVASN 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD276	NP_001019907.1	IG_like	37..138	CDD:214653	2/7 (29%)
		Ig	43..139	CDD:299845	2/8 (25%)
		Ig	148..231	CDD:299845	14/84 (17%)
		IG_like	156..237	CDD:214653	14/82 (17%)
		IG_like	255..356	CDD:214653	24/122 (20%)
		Ig	261..357	CDD:299845	21/113 (19%)
		Ig	366..449	CDD:299845	19/87 (22%)
		IG_like	374..456	CDD:214653	16/79 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..534
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	18/97 (19%)
		IG_like	182..262	CDD:214653	15/79 (19%)
		IG_like	285..362	CDD:214653	18/85 (21%)
		IGc2	292..361	CDD:197706	15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910