Protein Alignment CD276 and igcm-2

DIOPT Version :9

• Sequence 1: NP_001019907.1
• Gene: CD276 / 80381
• HGNCID: 19137
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_001362087.1
• Gene: igcm-2 / 180913
• WormBaseID: WBGene00020130
• Length: 802
• Species: Caenorhabditis elegans
• Alignment Length: 492
• Identity: 100/492 - (20%)
• Similarity: 170/492 - (34%)
• Gaps: 125/492 - (25%)

Human    43 GTDATLCCSFS--PEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQ-GN 104
            |...||.||.|  .|..|||.     |: .|.:.::.:|  ||:||..    |......||: |.
 Worm    28 GAPITLPCSISLFNEESFSLD-----WR-KDGQLILSAF--GQEQGHV----TPTLQGRLARDGF 80

Human   105 ASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAP---------YSKPSMTLEPNKDL----R 156
            ..:.:..|...|.|.:.|.|:       ..|.|...|         .:.|.:.:.|:|:.    :
 Worm    81 LGITIHSVTDGDAGVYQCIVT-------KFSKQPTRPEKGLSAKLVVNVPPVIISPSKNAIIHKK 138

Human   157 PGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCL 221
            .|..:...|.: :|.|..|:.|...:.:..|..|.|.....|              |..|.|:||
 Worm   139 VGADLIFECKA-EGAPSPEITWSRNEQIISTSPVLTLSNLEE--------------GDKGLYTCL 188

Human   222 VRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQ 286
                          .:..:.:.|.:::|:..:..::.|:..:.|:           :...|:.|
 Worm   189 --------------AVNIEGNSTSSIDVRFTKATILDLIPLNKTV-----------IEGSNVFW- 227

Human   287 LTDTKQLVHSFTEGRDQGSAYA----NRTALFPDLLAQGN---ASLRLQRVRVADEGSFTCFV-- 342
                    |.....:....:|:    .:......|..:.|   ..|.||.||.:|.|.:||..
 Worm   228 --------HCHANAQATAISYSWLFEKKPIKTTSLGLRSNIRSGDLSLQDVRKSDSGWYTCEAKN 284

Human   343 SIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGN 407
            |..:..|:...|.|..| .:|..:.:|.:.:..|...|::|............|..      .|:
 Worm   285 SAGETTSSTAYLHVFYP-PEPLSSHQPVQTVASGRNTTVSCDVIANPTPTSYTWSK------NGH 342

Human   408 VTTSQMANEQGLFDVHSVLRVVL-GANGTYSCLVRNPVLQQDAHGSVT----ITGQPMTF---PP 464
            ...:|.::       |.::.... |..|.|.|...|..    ..||:.    |..:|..|   ||
 Worm   343 YLPTQASS-------HIIISYAKPGDGGIYGCQADNIA----GKGSIVETHLIVAEPPVFTVAPP 396

Human   465 EALWVTVG--LSVCLIALLVALAFVCW----RKIKQS 495
            ..:.|.:|  :|:........:..|.|    ::|.||
 Worm   397 SEIKVRLGDQVSIPCQGFGDPMPIVYWIRDKKRINQS 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CD276	NP_001019907.1	IG_like	37..138	CDD:214653	27/97 (28%)
		Ig	43..139	CDD:299845	28/98 (29%)
		Ig	148..231	CDD:299845	17/86 (20%)
		IG_like	156..237	CDD:214653	15/80 (19%)
		IG_like	255..356	CDD:214653	20/109 (18%)
		Ig	261..357	CDD:299845	19/104 (18%)
		Ig	366..449	CDD:299845	13/83 (16%)
		IG_like	374..456	CDD:214653	14/86 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..534
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	25/84 (30%)
		Ig	124..200	CDD:386229	18/104 (17%)
		IG_like	214..298	CDD:214653	19/103 (18%)
		Ig_3	309..371	CDD:372822	12/74 (16%)
		Ig	389..467	CDD:386229	11/45 (24%)
		FN3	476..548	CDD:238020

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910