DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp11a1 and Cyp12d1-d

DIOPT Version :9

Sequence 1:	NP_694485.2	Gene:	cyp11a1 / 80374	ZFINID:	ZDB-GENE-010306-1	Length:	509	Species:	Danio rerio
Sequence 2:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	130/543 - (23%)
Similarity:	239/543 - (44%)	Gaps:	83/543 - (15%)

- Green bases have known domain annotations that are detailed below.

Zfish    14 SLSSLKNL-LQVKVTRSGRAPQ-------NSTV----QPFNKIP--------------GRWRNSL 52
            :|||.::: :.|...||.|:..       .|::    :.:::||              |.::|:
  Fly     3 TLSSARSVAIYVGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMPGGEFQNA- 66

Zfish    53 LSVLAFTKMGGLRNVHRIMVHNFKTFGPIY--REKVGIYDSVYIIKPEDGAILFKAEGHHPNRIN 115
             |:..:|  ..:|          |.:|.||  ....|..|.|.....:|..::|:.||..|.|..
  Fly    67 -SITEYT--SAMR----------KRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDG 118

Zfish   116 VDAWTAYRDY-RNQKY----GVLLKEGKAWKTDRMILNKELLLPKLQGTFVPLLEEVGQDFVARV 175
            :|:...:|:: |...|    |::..:.:||...|..:|...:.|:....:...|..:..:|:.|:
  Fly   119 LDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERI 183

Zfish   176 NKQIERSGQKQWTTDLTHDLFKFSLESVSAVLYGERLGLLLDNIDPE-----FQHFIDCVSVMFK 235
             |:|......:...|.|.::.:...||:..|.:..::||:..|.|..     ||...|...:.||
  Fly   184 -KEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFK 247

Zfish   236 TTSPMLYLPPGLLRSIGSNIWKNHVEAWDGIFNQADRYIQNIFKQWKENPEGNGKYPGV---LAI 297
                 |.:.|.:.:.|.:..::......:...|.:.       |..|||.:...|....   :..
  Fly   248 -----LDIQPSMWKIISTPTYRKMKRTLNDSLNVSQ-------KMLKENQDALEKRRQAGEKINS 300

Zfish   298 LLMQDKLSIEDIKASV---TELMAGGVDSVTFTLLWTLYELARQPDLQDELRAEISAARIAFKGD 359
            ..|.::|...|.|.:|   .:::..|||:....|...|..|::.||.|.:||.|:.:. :..|..
  Fly   301 NSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSI-MPTKDS 364

Zfish   360 MV--QMVKMIPLLKAALKETLRLHPVAMSLPRFITEDTVIQNYHIPAGTLVQLGVYAMGRDHQFF 422
            ::  :.:|.:|.|:|.:|||||.:|......|....|.::..|.:|.||.|.||...:.::..::
  Fly   365 LLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYY 429

Zfish   423 PKPEQYCPSRWI-----SSKRQY--FKSLGFGFGPRQCLGRRIAETEMQIFLIHMLENFRIEKQK 480
            |:|:::.|.||:     ..|.|.  |..|.||||||.|:|:|:.:.||:..:..::.||.:|..:
  Fly   430 PRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNR 494

Zfish   481 QIEVRSKFELLLMPEKPIMLTIK 503
              :....|:.:.:.|..|....|
  Fly   495 --DASRPFKTMFLMEPAITFPFK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp11a1	NP_694485.2	p450	66..502	CDD:278495	114/462 (25%)
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	114/465 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820