Protein Alignment COASY and Ppat-Dpck

DIOPT Version :10

• Sequence 1: NP_001035997.2
• Gene: COASY / 80347
• HGNCID: 29932
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_647985.1
• Gene: Ppat-Dpck / 38647
• FlyBaseID: FBgn0035632
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 563
• Identity: 209/563 - (37%)
• Similarity: 302/563 - (53%)
• Gaps: 54/563 - (9%)

Human    35 SGLLVLTTPLASLAPRLASILTSAARLVNHTLYVHLQPGMSLEGPAQPQSSPVQATFEVLDFITH 99
            :||||:     |....|...|.:..:.|| :||:||....|....:.....||...     .|:.
  Fly     5 TGLLVV-----SNIKHLGKSLRAIEKYVN-SLYIHLNVAGSTSTTSPVPPPPVWGR-----LISQ 58

Human   100 LYAGAD--VHRHLDVRILLTNIRTKSTFLPPLPTSVQNLAHPPEVVLTDFQTLDGSQYNPVKQQL 162
            |||.:.  |.:.||:|:|::.:|       |.......|..|.:::.:|       .::|
  Fly    59 LYANSSSYVGKQLDLRVLVSPLR-------PGANGSLKLRQPVDLIFSD-------AHHP----- 104

Human   163 VRYATSCYSCCPRLASVLLYSDYGIGEVPVEPLDVPLPSTIRPASPVAGSPKQPVRGYYRGAVGG 227
                    ..|.||.     :|..|.: |...||..:.|.:....    ...||.:.|....:||
  Fly   105 --------ELCDRLR-----ADLNISK-PTIFLDDSVISDLSAQQ----DDTQPPKVYPSVVLGG 151

Human   228 TFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPELLQPYTERVEHLSEFLVDIKPSLT 292
            ||||:|..||:.|:.|.:...::|||||....:.|.|.||:|:.|..||:..|.||||||..:|.
  Fly   152 TFDRIHLGHKIFLTQAVLRTCKRLVVGVTTSAMTKGKTLPDLILPVEERIARLREFLVDIDDTLQ 216

Human   293 FDVIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAINRFRLENDLEELALYQIQLLKDLRHTENEE 357
            ::::|:.||:||...||.|:.:|||.||.|||..:|..|....|.||.::.|.:::...|....|
  Fly   217 YEIVPIDDPFGPTQVDPDLDMIVVSAETLRGGQKVNEVRSAKQLRELEIFVIDIVESNVHDGIHE 281

Human   358 DKVSSSSFRQRMLGNLLRPPYERPELPTCLYVIGLTGISGSGKSSIAQRLKGLGAFVIDSDHLGH 422
            .|||||:.|..:||...|.|..||:||...|:|||||...||||.:.:||..:||.|||.|.:.|
  Fly   282 TKVSSSNTRIDLLGTRWRRPEPRPQLPPRPYIIGLTGGIASGKSKMGERLANMGAHVIDCDKVAH 346

Human   423 RAYAPGGPAYQPVVEAFGTDILHKDGIINRKVLGSRVFGNKKQLKILTDIMWP-IIAKLAREEMD 486
            ..|.||...|..:|:.||..|:..||.|:|..||..||.:.|||:.|..|:|| :||::.| .:|
  Fly   347 DVYEPGQLCYTRIVQHFGQGIVSDDGRIDRSKLGPLVFADPKQLQALNGIVWPELIAEVNR-RLD 410

Human   487 --RAVAEGKRVCVIDAAVLLEAGWQNLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMS 549
              |:.|:..||.|::|||||.|||:...||||:.::|..||||||:||:.|||..||.||.||:.
  Fly   411 ALRSQADVPRVVVLEAAVLLRAGWETNCHEVWSMIVPPDEAVRRIIERNKLSEVEAQKRLASQVP 475

Human   550 GQQLVEQSHVVLSTLWEPHITQRQVEKAWALLQKRIPKTHQAL 592
            ..::|.:|||:.|:.|:...||:|.|:||.:|.|.:.....:|
  Fly   476 NSEIVAKSHVIFSSQWDHEFTQKQAERAWKMLTKELDSYQSSL 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COASY	NP_001035997.2	PPAT_CoAS	222..368	CDD:173915	62/145 (43%)
		DPCK	389..565	CDD:238980	85/178 (48%)
Ppat-Dpck	NP_647985.1	PPAT_CoAS	147..290	CDD:173915	61/142 (43%)
		DPCK	313..494	CDD:238980	86/181 (48%)