Protein Alignment PNPLA3 and pnpla3

DIOPT Version :10

• Sequence 1: NP_079501.2
• Gene: PNPLA3 / 80339
• HGNCID: 18590
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_001015693.1
• Gene: pnpla3 / 548410
• XenbaseID: XB-GENE-5855123
• Length: 498
• Species: Xenopus tropicalis
• Alignment Length: 418
• Identity: 200/418 - (47%)
• Similarity: 270/418 - (64%)
• Gaps: 23/418 - (5%)

Human     1 MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQT 65
            |:|.||||:|||.||||||.||||.:.||.|.||.|:..|..::|||||||:...::.|..|.|.
 Frog     1 MFDLERGWNLSFCGCGFLGVYHVGVSSCLQERAPRLITQANKIYGASAGALNAAALVCGCSLAQC 65

Human    66 LQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTRVSDGENVLVS 130
            ...:..:.::||.||:|..||||||.|.|::||.:.||.|.|:|.|||:.|||||||||||||||
 Frog    66 CSDVLGVAKEARKRNLGPLHPSFNLVKILKKGLYRNLPENAHELASGKLCISLTRVSDGENVLVS 130

Human   131 DFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICP 195
            :|.||:|::.||:||.|:|.|.||||||||||||||||:|:|:|..|.|.|||||||.||.||||
 Frog   131 EFNSKEELIQALICSAFVPIYCGLIPPSFRGVRYVDGGISNNLPEYDLKNTITVSPFSGESDICP 195

Human   196 K-VKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQ 259
            : ..||||..:.:|..|::...||||.|:||..||:..||||:|.:||.||.|||::..:.:.|.
 Frog   196 RDSNSTNFHELRVTNTSIQFSLGNLYRLTRALFPPEPTVLGEMCQQGYNDALRFLKDNNLLSLPS 260

Human   260 PGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDELLDHLRLSIL----PW--DESILD 318
            |       ..|..:|.|....:|...:.:....:.|.|.|     |:..:|    ||  |:.|::
 Frog   261 P-------AADLCLAFPKATPLSHHLTCDCCVKSKREEED-----LKRKVLEGPTPWSLDKRIME 313

Human   319 TLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTLPVESAIAIVQRLVTWLPDMPDDV 383
            .|.|.|...|.|..::|.|...:|.:|||:|:.||:::|.||||||.:::..|||.|.||||:|:
 Frog   314 RLPPSLCYVLQEACREKNGLYHQISSLLPMRVASYMVMPYTLPVESVVSVALRLVDWFPDMPEDM 378

Human   384 LWLQ----WVTSQVFTRVLMCLLPASRS 407
            .|:|    .|...|:::....|||:.||
 Frog   379 RWMQEQVRSVAGAVYSQAKKRLLPSVRS 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA3	NP_079501.2	Pat_PNPLA3	8..259	CDD:132860	141/251 (56%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	14..19		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	45..49		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	166..168		1/1 (100%)
pnpla3	NP_001015693.1	Pat_PNPLA2	4..253	CDD:132859	144/248 (58%)