Protein Alignment PNPLA3 and pnpla3

DIOPT Version :10

• Sequence 1: NP_079501.2
• Gene: PNPLA3 / 80339
• HGNCID: 18590
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_001002338.2
• Gene: pnpla3 / 436610
• ZFINID: ZDB-GENE-040718-27
• Length: 473
• Species: Danio rerio
• Alignment Length: 494
• Identity: 199/494 - (40%)
• Similarity: 279/494 - (56%)
• Gaps: 58/494 - (11%)

Human     1 MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQT 65
            |:|.:.||:||||||||||.||:|...||.|.||:|:|.|..::|||||||....:.:...:|:.
Zfish     1 MFDLKEGWNLSFAGCGFLGIYHIGVASCLLEQAPYLIRGATKIYGASAGALTASVLTTEACIEKC 65

Human    66 LQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISLTRVSDGENVLVS 130
            .:.:.::.::||.||:|..||:||:.|.:|.||.:.||:|.|.|.||::.:|||||.||:|||||
Zfish    66 CEDVINVAKEARKRNLGPLHPTFNIVKVIRGGLYRDLPSNAHTLSSGRLCVSLTRVMDGQNVLVS 130

Human   131 DFRSKDEVVDALVCSCFIPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICP 195
            ||.||:|::.||:||||||.|.|||||:||||||||||:|||:|..:.|.|||||||.||.||||
Zfish   131 DFSSKEELIQALICSCFIPVYCGLIPPAFRGVRYVDGGISDNLPQSELKNTITVSPFSGESDICP 195

Human   196 KVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQP 260
            |..||:|..:..|..|::....|.|.||:|..||:.|||.|:|..||.||.|||:|..:.....|
Zfish   196 KDNSTSFHELRFTNTSIQFNLDNAYRLSKALFPPEPKVLAEMCQSGYKDALRFLQENNLLQAACP 260

Human   261 GLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDELLDHLRLSILP----W-DESILDTL 320
            |:..:.....|....|...|..::.:.:...|.            ||.:|.    | ||.|:|.|
Zfish   261 GVDMALIQATPTCCCPGKKNPVVEETTKEWVLR------------RLRLLRKHHWWLDEQIVDNL 313

Human   321 SPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTLPVESAIAIVQRLVTWLPDMPDDVLW 385
            ...:.....:..::|.|.::::..|||:|:.||::||.|||||||.:..||...|:|::|.||.|
Zfish   314 PTPIKKVFCDACREKHGLLAQVTGLLPVRVASYMLLPYTLPVESAYSAAQRFWEWIPEVPADVRW 378

Human   386 LQWVTSQVF--------------TRVLMCLL--PASRSQMPVSSQQASPCT---PEQ----DWPC 427
            |..|...|:              ..:..|:.  |.:..|||:..     ||   |..    |...
Zfish   379 LTEVAGGVYRLAWKGAASEANSGAPLRRCVSEPPMADLQMPIKD-----CTGHIPHSASTLDSYK 438

Human   428 WT------PCSPKGCPAETKAEATPRSILRSSLNFFLGN 460
            ||      ..|...||....:|:       ..::||:|:
Zfish   439 WTFPNNIHTTSSIDCPESPVSES-------RQMSFFVGS 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA3	NP_079501.2	Pat_PNPLA3	8..259	CDD:132860	135/250 (54%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	14..19		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	45..49		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	166..168		1/1 (100%)
pnpla3	NP_001002338.2	None