Protein Alignment PABPC1L and pabp

DIOPT Version :9

• Sequence 1: NP_001359108.1
• Gene: PABPC1L / 80336
• HGNCID: 15797
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_593377.1
• Gene: pabp / 2541505
• PomBaseID: SPAC57A7.04c
• Length: 653
• Species: Schizosaccharomyces pombe
• Alignment Length: 634
• Identity: 297/634 - (46%)
• Similarity: 394/634 - (62%)
• Gaps: 95/634 - (14%)

Human     4 SGSGYPLASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDVATRRSLGYAYINFQQPADAERA 68
            ||:....||||||:|.|.||||||:|.|:..||:.|||||||..|||||||||:||....|.|:|
pombe    73 SGTAPTSASLYVGELDPSVTEAMLFELFNSIGPVASIRVCRDAVTRRSLGYAYVNFHNMEDGEKA 137

Human    69 LDTMNFEMLKGQPIRIMWSQRDPGLRKSGVGNIFIKNLEDSIDNKALYDTFSTFGNILSCKVACD 133
            ||.:|:.::||:|.|||||||||.|||.|.||:|||||:.:||||||:||||.||.|||||||.|
pombe   138 LDELNYTLIKGRPCRIMWSQRDPSLRKMGTGNVFIKNLDPAIDNKALHDTFSAFGKILSCKVAVD 202

Human   134 EHG-SRGFGFVHFETHEAAQQAINTMNGMLLNDRKVFVGHFKSRREREAELGARALEFTNIYVKN 197
            |.| ::|:|||||::.|:|..||..:|||||||:||:|||..|||||::::.|....|||:|:||
pombe   203 ELGNAKGYGFVHFDSVESANAAIEHVNGMLLNDKKVYVGHHVSRRERQSKVEALKANFTNVYIKN 267

Human   198 LPVDVDEQGLQDLFSQFGKMLSVKVMRDNSGHSRCFGFVNFEKHEEAQKAVVHMNGKEVSGRLLY 262
            |..::.||...|||.|||::.|:.:::|.:...|.|||||:..||.|||||..:|.||..|:.||
pombe   268 LDTEITEQEFSDLFGQFGEITSLSLVKDQNDKPRGFGFVNYANHECAQKAVDELNDKEYKGKKLY 332

Human   263 AGRAQKRVERQNELKRRFEQMKQDRLRRYQGVNLYVKNLDDSIDDDKLRKEFSPYGVITSAKVMT 327
            .|||||:.||:.||::|:||||.:::.:||||||::|||.|.:||::|:.|||.:|.|||||:||
pombe   333 VGRAQKKHEREEELRKRYEQMKLEKMNKYQGVNLFIKNLQDEVDDERLKAEFSAFGTITSAKIMT 397

Human   328 -EGGHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAIL------TNQY--M 383
             |.|.||||||||:::||||.|||||||.|::..||||||||||||.|::.|      .||:  .
pombe   398 DEQGKSKGFGFVCYTTPEEANKAVTEMNQRMLAGKPLYVALAQRKEVRRSQLEAQIQARNQFRLQ 462

Human   384 QRLSTMRTL-------SNPLLGSFQQPSSYFLPA------MPQPPAQAAYYGCGPVTPTQ----- 430
            |:::....:       :.||:   ..|..|.:||      ||..|.........|..|||
pombe   463 QQVAAAAGIPAVQYGATGPLI---YGPGGYPIPAAVNGRGMPMVPGHNGPMPMYPGMPTQFPAGG 524

Human   431 PAPRW---TSQPPRPSSAYPPGASMVRPPVVPRRPPAHISSVRQASTQVPRTVPHTQRVANIGTQ 492
            |||.:   .::.|.|:...|    |:.|..||...||...:|
pombe   525 PAPGYPGMNARGPVPAQGRP----MMMPGSVPSAGPAEAEAV----------------------- 562

Human   493 TTGPSGVGCCTPGRPLLPCKCSSAAHSTYRVQEPAVHIPGQEPLTASMLAAAPLHEQKQMIGERL 557
               |:     .||.|                          |..||:.|||.|...:||::||.|
pombe   563 ---PA-----VPGMP--------------------------ERFTAADLAAVPEESRKQVLGELL 593

Human   558 YPLIHDVHTQLAGKITGMLLEIDNSELLLMLESPESLHAKIDEAVAVLQ 606
            ||.:.....:|:|||||||||:.|||||.:||...:|:.:::||:.|||
pombe   594 YPKVFVREEKLSGKITGMLLEMPNSELLELLEDDSALNERVNEAIGVLQ 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPC1L	NP_001359108.1	PABP-1234	11..606	CDD:130689	293/625 (47%)
pabp	NP_593377.1	PABP-1234	80..642	CDD:130689	293/625 (47%)
		RRM1_I_PABPs	81..160	CDD:240824	51/78 (65%)
		RRM2_I_PABPs	166..242	CDD:240825	50/75 (67%)
		RRM3_I_PABPs	260..339	CDD:240826	40/78 (51%)
		RRM4_I_PABPs	363..441	CDD:240827	52/77 (68%)
		PolyA	581..644	CDD:197769	31/62 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	102	1.000	Domainoid score	I2035
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77989
Inparanoid	1	1.050	545	1.000	Inparanoid score	I238
OMA	1	1.010	-	-		QHG53624
OrthoFinder	1	1.000	-	-		FOG0000294
OrthoInspector	1	1.000	-	-		otm53703
orthoMCL	1	0.900	-	-		OOG6_100425
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X269
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.970