Protein Alignment WNT10A and Wnt5

DIOPT Version :10

• Sequence 1: NP_079492.2
• Gene: WNT10A / 80326
• HGNCID: 13829
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_476924.1
• Gene: Wnt5 / 32838
• FlyBaseID: FBgn0010194
• Length: 1004
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 135/516 - (26%)
• Similarity: 186/516 - (36%)
• Gaps: 207/516 - (40%)

Human    55 LNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYE 119
            ||.|. |.:..|||..|.:.||:|..|..:..:|.:.||.|||.||:::|||||   |.|.....
  Fly   543 LNPNN-CYSAIGLSNSQKKQCVKHTSVMPAISRGARAAIQECQFQFKNRRWNCS---TTNDETVF 603

Human   120 SPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQR 184
            .|:.|....|.||.:|:|||.|...::.||..|:|.:|.|....|      .::||
  Fly   604 GPMTSLAAPEMAFIHALAAATVTSFIARACRDGQLASCSCSRGSR------PKQLH--------- 653

Human   185 GKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREP--------------- 234
                                  |.|:||||..::.|..:|:.||:||||.
  Fly   654 ----------------------DDWKWGGCGDNLEFAYKFATDFIDSREKETNRETRGVKRKREE 696

Human   235 ------HRD-------------------------------------------------------- 237
                  |.|
  Fly   697 INKNRMHSDDTNAFNIGIKRNKNVDAKNDTSLVVRNVRKSTEAENSHILNENFDQHLLELEQRIT 761

Human   238 ----------------------------------------------------------------- 237
                                                                             
  Fly   762 KEILTSKIDEEEMIKLQEKIKQEIVNTKFFKGEQQPRKKKRKNQRAAADAPAYPRNGIKESYKDG 826

Human   238 ---------IHAR--MRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLR 291
                     :.||  |.||||..||:||::..|..|||||.||||.|.||||.....|.:|..||
  Fly   827 GILPRSTATVKARSLMNLHNNEAGRRAVIKKARITCKCHGVSGSCSLITCWQQLSSIREIGDYLR 891

Human   292 SRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAG 356
            .::..||.::.:.|...|::......|             :..||:|.::|||:|.....|...|
  Fly   892 EKYEGATKVKINKRGRLQIKDLQFKVP-------------TAHDLIYLDESPDWCRNSYALHWPG 943

Human   357 TVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK 417
            |.||:|:|:|:|.:.|..:|||||:|......:|||:|:|||||.|.||.|........||
  Fly   944 THGRVCHKNSSGLESCAILCCGRGYNTKNIIVNERCNCKFHWCCQVKCEVCTKVLEEHTCK 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNT10A	NP_079492.2	Wnt	58..417	CDD:393294	131/511 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..331		3/30 (10%)
Wnt5	NP_476924.1	Wnt_Wnt5	548..1004	CDD:381711	130/508 (26%)