DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPEB4 and cpeb4a

DIOPT Version :9

Sequence 1:	NP_085130.2	Gene:	CPEB4 / 80315	HGNCID:	21747	Length:	729	Species:	Homo sapiens
Sequence 2:	XP_005173170.2	Gene:	cpeb4a / 393956	ZFINID:	ZDB-GENE-040426-1557	Length:	711	Species:	Danio rerio

Alignment Length:	743	Identity:	554/743 - (74%)
Similarity:	604/743 - (81%)	Gaps:	46/743 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAP 65
            ||||||  ||::|..|||.||||.||.||...|||...|||.|||:||...||.|.||||||||.
Zfish     1 MGDYGF--LVKNNAANKSVFPVRIHPQLQHTVHHQTTPPSPPAFISNNNTTNGGSVGSAWLFPAV 63

Human    66 ATH-NIQDEILGSE--KAKSQQQEQQDPLEKQQLSPSPGQE-AGILPETEKAKSEENQGDNSS-E 125
            ..| |:||:||.||  ||...|||.|:..:||.|||...|| .||:.|.:.|..||||.:..: |
Zfish    64 TPHSNMQDDILESEMSKAPQLQQESQEGQDKQTLSPPGHQEPPGIISELDNALPEENQLEKGTME 128

Human   126 NGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFF 190
            |.||||.:|:|||||:||||||.||:||..|..:||:|||||||:||.|:.|:.||:| |:..||
Zfish   129 NANGKETLRLESPVLSGFDYQETTGIGTLAQSSSSSSSSLTGFSSWSTAMPPNPSTLI-EEVGFF 192

Human   191 HQGGVPAASANNG--ALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPH-HPHFQHHHSQHQQQRRS 252
            :|    ||:.||.  .||||:|.||.|.||||:||.||||||||||. ||||||.|:||   |||
Zfish   193 NQ----AATTNNAPPPLLFQSFSHHTSTGFGGNFSHQIGPLSQHHPSPHPHFQHPHNQH---RRS 250

Human   253 PASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSS-SWSPGGGGYGGWGGSQGRD 316
            .||||||||:||:|||||||||.|||:||||||.||||||.|||| |||| ||||||||.||||:
Zfish   251 SASPHPPPFSHRSAAFNQLPHLGNNLSKPPSPWGSYQSPSSTPSSTSWSP-GGGYGGWGSSQGRE 314

Human   317 HRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTF 381
            :||   ||:.||||||||||:|.:|..|.|||.|.:|.|..|.||||::||.::||||.:|.|:|
Zfish   315 YRR---GGVNPLNSISPLKKSFPNNQTQTQKYPRNNSGFNTKPWMEDTINRNESIFPFQERSRSF 376

Human   382 D---MHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMED--GFLD 441
            |   |||||:|||||||||.|::|                 ||.||||||.||||||||  .:.:
Zfish   377 DGFSMHSLENSLIDIMRAEQDSLK-----------------ARNYGRRRGHSSLFPMEDERSYGE 424

Human   442 DGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKA 506
            |.|.||.| |||||||.|.||||||:|||||||||||||||||||||||||||||.|.|||||||
Zfish   425 DERSDQSL-SGLGSPHSFPHQNGERIERYSRKVFVGGLPPDIDEDEITASFRRFGHLFVDWPHKA 488

Human   507 ESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMD 571
            |||||||||||||||||||||||||||||:|||||||||||||||||||||||||||:|||||||
Zfish   489 ESKSYFPPKGYAFLLFQDESSVQALIDACMEEDGKLYLCVSSPTIKDKPVQIRPWNLNDSDFVMD 553

Human   572 GSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYI 636
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   554 GSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYI 618

Human   637 AAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAI 701
            ||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
Zfish   619 AAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWAAI 683

Human   702 HSRAGREFHKPLVKEGGDRPRHISFRWN 729
            ||||||||||||||||||||||||||||
Zfish   684 HSRAGREFHKPLVKEGGDRPRHISFRWN 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPEB4	NP_085130.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..49		18/28 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..133		28/58 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..328		85/111 (77%)
		RRM1_CPEB2_like	472..563	CDD:410123	87/90 (97%)
		RNA-binding. /evidence=ECO:0007744\|PDB:5DIF	541..543		1/1 (100%)
		RRM2_CPEB2_like	580..660	CDD:410125	79/79 (100%)
		CEBP_ZZ	655..716	CDD:406704	59/60 (98%)
cpeb4a	XP_005173170.2	RRM	333..616	CDD:223796	236/300 (79%)
		RRM1_CPEB2_like	454..545	CDD:241168	87/90 (97%)
		RRM2_CPEB2_like	562..642	CDD:241170	79/79 (100%)
		CEBP_ZZ	637..698	CDD:292976	59/60 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194344059
Domainoid	1	1.000	189	1.000	Domainoid score	I13696
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H12736
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075356at2759
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	1	1.100	-	-	O	PTHR12566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4704
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	14	14.240