DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPEB4 and cpeb4b

DIOPT Version :9

Sequence 1:	NP_085130.2	Gene:	CPEB4 / 80315	HGNCID:	21747	Length:	729	Species:	Homo sapiens
Sequence 2:	NP_001338642.1	Gene:	cpeb4b / 100333151	ZFINID:	ZDB-GENE-170601-167	Length:	726	Species:	Danio rerio

Alignment Length:	737	Identity:	602/737 - (81%)
Similarity:	649/737 - (88%)	Gaps:	19/737 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAP 65
            |||||||||||:|||||||||||.||||||||||.|||.|||||||:..|.||||:.|.|||||.
Zfish     1 MGDYGFGVLVQNNTGNKSAFPVRIHPHLQPPHHHPNATASPAAFINSTPAGNGSSSASTWLFPAA 65

Human    66 ATH-NIQDEILGSEKAKSQQQEQQDPLEKQQLSP-SPG-QEAGILPETEKAKSEENQGDN-SSEN 126
            ..| |:|||||||:|.|.||||.|:..:|||... ||| ||:.|:.|.|||::||.:.:: |||.
Zfish    66 GGHNNMQDEILGSDKPKVQQQELQETQDKQQQQQLSPGHQESTIISELEKARAEEGKVESGSSEG 130

Human   127 GNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFH 191
            .|||||:|:||||||.|||||.:||||:.|  :|::||||.|:||||||..:.|||||||.|||:
Zfish   131 TNGKEKLRLESPVLTAFDYQEPSGLGTAAQ--SSTSSSLTSFNNWSAAIPATPSTIINEDISFFN 193

Human   192 QGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASP 256
                ||||||||.||||||.|||||||||:|||||||:|||||.||||||.||||||.|||||||
Zfish   194 ----PAASANNGPLLFQNFSHHVSPGFGGNFSPQIGPISQHHPPHPHFQHPHSQHQQHRRSPASP 254

Human   257 HPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSS-SWSPGGGGYGGWGGSQGRDHRRG 320
            |||||.||:|.|.|||||:|||:||||||.|||||||:||| |||| |||||||||||||::|||
Zfish   255 HPPPFPHRSAPFGQLPHLSNNLSKPPSPWGSYQSPSPSPSSTSWSP-GGGYGGWGGSQGREYRRG 318

Human   321 LNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFD--- 382
            ||||:|||||||||||.|.:||:..|||:|.|..|.|||||:|   |::|||||.||||:||
Zfish   319 LNGGMTPLNSISPLKKTFPNNHMPQQKYSRASPGFNPKSWMDD---RSENIFPFQDRPRSFDGFN 380

Human   383 MHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQ 447
            |||||:|||||||||.||:||||.:::||.||.|.||||.||||||.||||||||||.|:.|.||
Zfish   381 MHSLENSLIDIMRAEQDTLKGRLGFTHPGGDSPLPINARNYGRRRGHSSLFPMEDGFPDEERADQ 445

Human   448 PLHSGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYF 512
            .| .||.|||||.||||||||||||||||||||||||||||||||||||.|.|||||||||||||
Zfish   446 SL-PGLSSPHCFPHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGHLFVDWPHKAESKSYF 509

Human   513 PPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLD 577
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
Zfish   510 PPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLNDSDFVMDGSQPLD 574

Human   578 PRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISAR 642
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   575 PRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISAR 639

Human   643 FVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGR 707
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
Zfish   640 FVQLQHGEIDKRVEVKPYVLDDQLCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGR 704

Human   708 EFHKPLVKEGGDRPRHISFRWN 729
            ||||||||||||||||||||||
Zfish   705 EFHKPLVKEGGDRPRHISFRWN 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPEB4	NP_085130.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..49		24/28 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..133		29/57 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..328		92/110 (84%)
		RRM1_CPEB2_like	472..563	CDD:410123	88/90 (98%)
		RNA-binding. /evidence=ECO:0007744\|PDB:5DIF	541..543		1/1 (100%)
		RRM2_CPEB2_like	580..660	CDD:410125	79/79 (100%)
		CEBP_ZZ	655..716	CDD:406704	59/60 (98%)
cpeb4b	NP_001338642.1	RRM1_CPEB2_like	469..560	CDD:241168	88/90 (98%)
		RRM2_CPEB2_like	577..657	CDD:241170	79/79 (100%)
		CEBP_ZZ	652..713	CDD:318563	59/60 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	690	1.000	Domainoid score	I1181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1225	1.000	Inparanoid score	I1533
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39436
OrthoDB	1	1.010	-	-		D1075356at2759
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		oto50372
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	1	1.100	-	-	LDO	PTHR12566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.480