Protein Alignment NCOA4 and ncoa4

DIOPT Version :10

• Sequence 1: NP_001138732.1
• Gene: NCOA4 / 8031
• HGNCID: 7671
• Length: 650
• Species: Homo sapiens
• Sequence 2: XP_002940491.3
• Gene: ncoa4 / 100497661
• XenbaseID: XB-GENE-1008638
• Length: 634
• Species: Xenopus tropicalis
• Alignment Length: 642
• Identity: 297/642 - (46%)
• Similarity: 392/642 - (61%)
• Gaps: 66/642 - (10%)

Human    14 VRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLEC 78
            :|:|:..||...||  ::||.:|..|:::||.||..||:||||:|:|.||:|:|:||||||||||
 Frog    32 LRKMDLHQDHQFSS--QDPLSKCLQAKKELESAISAVLKAEQQVKENGRELKSQVHSCISRHLEC 94

Human    79 LRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGS 143
            ||||||||.||.|||.|||||.||||.||||.||||||||.||||...:.||.||:|||||||||
 Frog    95 LRSREVWLLEQADLIQQLKEEALQQQVQQLYWLLGQFNCLIHQLENPHSNDLVNQISVCLERLGS 159

Human   144 LTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEK-----RGC-IS 202
            |.||||:|:.|.||||...|||.||||||:||:...|.... :|:|...||:.:     ..| :.
 Frog   160 LALKPEESSTLYFEADVPVLRQAITTFGSIKTLNSGEEKQV-SSTAGPCPFVSQNPWLMNNCFVP 223

Human   203 MPEQKSASGIVAVPFSEWL--LGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNN 265
            ..||:..|.:...|.|:||  ..|...|....|||||...||||.:....|.::...:.......
 Frog   224 AAEQRPVSEMWNTPLSDWLQQKNSSNISQCYTPYIPSLCTQDWLLKNHAEEPNEELRKLKPNMEK 288

Human   266 VGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKL 330
            :.|.|..|.||||:|::....|.|:.|  ||||||..:.||.:..|.::|||||||::|..:
 Frog   289 IWGQLGELNNWLLQSQQKEDLKHNNSS--SSFSIEKLEDGDLDSQDLEDMDLSDWLISPTVT--- 348

Human   331 RKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPL 395
            ..|.:.:.:....||...:.|.::|||.|.::|.||.|.|...:||||||||||||:.:..||.:
 Frog   349 EDPTDVAEKWRAVFKAFDEDYKISDWLQKVEACGNCCGGQTSSLEIENLGNLKCLNEQIGGKKNV 413

Human   396 STPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPV 460
            |:.:   :.||:|:.|...|.::||:|||.|::||||||||:||||||.|||.||:||||||:..
 Frog   414 SSSN---DMWLLQSSQPVFKPQDVCKANEQCSTFAECVCDESCEKEALRKWLWKKDGKDKNGVLQ 475

Human   461 E-----PKPEPEKHKDSLNMWLCPRK---EVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRP 517
            :     ...||||.|.|::|||.|.:   |.:..|:..:...||  ......:..:|||:|:.:.
 Frog   476 KQGQHLKNREPEKAKPSISMWLHPCRRDAESLSSTQKTEESDPS--LRHLMNLLETPLSKWIAKS 538

Human   518 PYKEGSPKEVPGTEDRAGKQKFK---SPMNTSWCSF----NTADWVLPGK---KMGNLSQLSSGE 572
            ..          ||::|.|:..:   ||:..:...|    |.|.||||.|   |:.||.| |:.|
 Frog   539 SQ----------TEEKASKENTQSKCSPLAETLSPFHLPLNAASWVLPSKNTDKLENLEQ-SAIE 592

Human   573 DKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQ 629
            |||||||||.                |:||||:||||||||:|..|||:||||:|||
 Frog   593 DKWLLRKKAH----------------DYYGLPSVCDLFACMKLAADKEQWLYRSPLQ 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NCOA4	NP_001138732.1	ARA70	<54..160	CDD:463604	80/105 (76%)
		ARA70	215..344	CDD:463604	45/130 (35%)
ncoa4	XP_002940491.3	ARA70	48..175	CDD:463604	90/126 (71%)
		ARA70	236..358	CDD:463604	45/126 (36%)