DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CUBN and Cubn

DIOPT Version :9

Sequence 1:	NP_001072.2	Gene:	CUBN / 8029	HGNCID:	2548	Length:	3623	Species:	Homo sapiens
Sequence 2:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster

Alignment Length:	3940	Identity:	1140/3940 - (28%)
Similarity:	1738/3940 - (44%)	Gaps:	575/3940 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    10 WSLLTLLI----FAE--VNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQNIEFRTGSL 68
            |:||.::.    .||  ||                  .|::.::.|||:|.:|:.:||.||....
  Fly    13 WTLLAIITDTWPIAEGFVN------------------SPKIISKDGNLIFESGANRNISFRLSGN 59

Human    69 GKIKLNDE-DLSECLHQIQKNK-------EDIIELKG-------------SAIGLPQNISSQ--- 109
            .::.:|:| |:.|.|.....:|       :|.::.:.             .|.||...:..|
  Fly    60 SRLTINEELDVMELLLATSGSKKRSGGKDDDFVDARELADQLADFNRRAFGANGLSAMLRVQQNR 124

Human   110 -------IYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLC 167
                   :.:..::|..||.:...::..::...|:|.||:|||||.|.:..|.|.|...::|..|
  Fly   125 TRGSMALLRRFQTRLRALENRVDRMKTDLEANSCASGPCENGGTCYNTYTGFRCQCRSAFEGTKC 189

Human   168 SADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSV-ARCVHGICE 231
            ..|||||.:|.||.|.|||||.|.|..|:|||.|.|..:|..|..:..||...|. ..|.||.|.
  Fly   190 EMDVNECALYEGTDLGCQNGGQCQNHFGTYSCLCQPGWHGMHCTQRKADCSQSSAWELCGHGSCV 254

Human   232 DLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPG--PCSTLVQCFNTQGSFYCGACPT 294
                ..|.:..|.|:|:.||..:..:|.|..|.||||....  ||||  .|.|..|||.|..||.
  Fly   255 ----PSADDAGYRCICEPGWKTNGLTPICGEDVDECSDSAAHKPCST--SCINLPGSFTCAPCPA 313

Human   295 GWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLT----DI--- 352
            |..|||..|.|::||:.||||||::|.|:|:||.||.||..||.|:.||||.|..:    ||
  Fly   314 GLTGNGVSCRDLDECQTNNGGCSLSPKVDCINTYGSYHCGECPVGWTGDGRKCERSPQDIDIPAG 378

Human   353 -----CSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQ-LSNICLSHPCLNGQ-CI 410
                 |...|..|:|.|||....|:.. |.|..|..|.||||||||. .:..|..:|||||. |:
  Fly   379 QTPRTCPAGNNPCYPTASCFLISGTTS-CRCPMGMVGTGYGPNGCVNGTTTNCKENPCLNGGICL 442

Human   411 DT-VSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTC--VDGVDSFSCECTRLWTGALCQVPQQ 472
            .. .|.|.|.|..|:....|....:.|..:||.|||.|  ....|.|.|:|...:.|.||:....
  Fly   443 FAGPSNYTCLCPIGFRPPICEPQPSPCDQHPCKNGGRCRPTTSGDLFVCQCLPGYRGRLCETRFS 507

Human   473 VCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDG 537
            .|...||..:|...|.....||.|:..|.|||:|....|:.:||..|.:|....|..::||:.||
  Fly   508 SCNGMLSAQSGRLRYPPEGTGYEHNAQCAWVIRTNESLVVNVTFNSFDVEDSTECRFDWLQINDG 572

Human   538 DSSSAFQLGRFCGSSLPH--ELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILT-GPYG 599
            .|::|..:||:||:.|||  .::||.|.||....|::.....||.:.|.:.:|:|||.|. ..:|
  Fly   573 RSAAAQIIGRYCGNHLPHGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHG 637

Human   600 SIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKF 664
            ::.|||.|||||..|||.|.:|......:..||.:|.||.|.:||.||:.|:|....::  |.|:
  Fly   638 TLASPGSPGNYPKNRDCRWQLVAPTTKRIKLTFFSLQLEQHANCNFDYVLIKDSISGRE--LAKY 700

Human   665 CTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFT 729
            |||.:..||......|.||||||::.||.||.:.|........|||.||..||.:.....:....
  Fly   701 CTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHYSVEERVPGCGGVYTAKEGTISESSTANTEP 765

Human   730 HTRQCVYMMKQPQGEQIQINFTHVE---LQCQSDSSQNYIEVRD-----GETLLGKVCGNGTISH 786
            ....|.|.:....|||:.|.|..:|   |.|        :||.|     |..|..|:||:.. |.
  Fly   766 GGVSCEYEIHLAVGEQVVIQFARLELDPLDC--------LEVLDITDEGGSILQEKICGSDA-SR 821

Human   787 IKSIT-NSVWIRFKIDASVEKASFRAVYQVACGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQP 849
            :...| .|.:.|.||.......||:..|::||..:|..| |.|.||.:||:...:|.|.:||...
  Fly   822 LNPPTFTSEFNRLKIKFYARAGSFQLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTA 886

Human   850 QSQVILLNFTVFEIGSSAHCETDYVEIGSSSI-LGSPENKK----YCGTDIP--SFITSVYNFLY 907
            .:.||.|....|::.:....:.|..|..:::: :....|:|    |||.:.|  :|::.. |:|.
  Fly   887 TNTVISLKRIDFQLTNGESDDDDNDECLTTNLRINDGLNRKILGPYCGKNQPEENFVSET-NYLQ 950

Human   908 VTFVKSSSTENHGFMAKFSAEDLA-----CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPN 967
            :.......:...||  ||....||     ||.:.|.|...|:.|.|.:.|.....|.|.|:...|
  Fly   951 LHLSTDVDSMGRGF--KFEYRALATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPAN 1013

Human   968 HLIHLMFETFHLEFHYNCTNDYLEVYDT-----DSETS--LGRYCGKSIPPSLTSSGNSLMLVFV 1025
            ..|.|.:.:|.||...:|..||||:||:     :.|.|  |.:|||.|:|..|.|....|:|.||
  Fly  1014 KAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKPLAKYCGNSVPEDLLSHSRQLVLKFV 1078

Human  1026 TDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHF 1090
            :|...:..||.:.| .......|........|..|||.:|.||....:|.:.:|.....|:.:..
  Fly  1079 SDYSESDGGFDLTY-TFEDRAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHLLEIQV 1142

Human  1091 TNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFS 1155
            .||.||:: .|...|:||:|:||...|||:|.|.|.::|..|...|:::.|...:|......||.
  Fly  1143 ENFELEQS-PNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSAINGRGFR 1206

Human  1156 AYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTL 1220
            ..|...:.||||:|.::.|...||.||..|.:.:.|.|.:....||...|..:|..||...||..
  Fly  1207 LRWRIFAFGCGGSLRSNMGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYY 1271

Human  1221 DYLAVYDG-PSSNSHLLTQLCGDE--KPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVV 1282
            |.:.:|.| ...|......||.|:  ..|||:...:...|...:|.....|||:..|:..|  :.
  Fly  1272 DSVKIYTGIKLPNQSPCKVLCKDDDLHNPLIQLENNKGTIVFDSDASNTFRGFRISYKANC--IR 1334

Human  1283 IVNQTYGILESIGYPNPYSEN--QHCNWTIRATTGN--TVNYTFLAFDLEHHINCST--DYLELY 1341
            .:..|.|.:||:.|..|:.|.  .:|:|||||..||  .|..:.||.. |.|:..:|  ..|.:.
  Fly  1335 NLTATTGTIESLNYMEPFWETIPINCSWTIRAPKGNRVLVEVSHLARH-EQHVPTATMPGGLYIV 1398

Human  1342 DGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPG 1406
            |     ||.....:.|.....|.:    :||.........||:.:.:.||..||.|..|.|.||.
  Fly  1399 D-----GRNVQEIVTPQAMNISGE----VLTVVHNASNVNFQLDYRIDGCMEELRGTFGFFQSPN 1454

Human  1407 FPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSP 1471
            :|..||.|.||.|.|..:..|:|:|||::.|:|....|..|.|.:..    |...:.........
  Fly  1455 YPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSN----HKNSVEVHERHCGS 1515

Human  1472 ENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDC 1536
            ...:.::|:|:.|.:||.:|.|.||.||.|:::.|...|||...|.:|.|.|||||..|.:::.|
  Fly  1516 TTKLVITSSGHRLHVRFISDNSHNGLGFEATYRTVKATCGGKLTARNGVIESPNYPLNYPAHSRC 1580

Human  1537 SWVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTM--SRLARTCGREQLANPIV-SSG 1594
            .|.:.|.::|:::....|.:||....|    :.|||......  .||.:.||.|...:.:: ||.
  Fly  1581 EWQVEVSQHHQIVFEMADLNLESGYDCNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSS 1645

Human  1595 NSLFLRFQSGPSRQNRGFRAQFRQACGGHILT--SSFDTVSSPRFPANYPNNQNCSWIIQAQPPL 1657
            |...:||.|..|...:|||..|.::||..|:.  :.||.:...|..|   .|::|.|:.||..|.
  Fly  1646 NMAVVRFISDDSVSKKGFRLHFHESCGQTIIVDETMFDYIQMSRQAA---RNESCLWVFQAVEPN 1707

Human  1658 NHITLSFTHFELERSTT--------CARDFVEILDGGHEDAPLRGRYCGTDMPHP--ITSFSSAL 1712
            ..|..:.||.:|.....        |....|:|.:|.......|.::|.:   ||  :.|...||
  Fly  1708 KRIIFTPTHVKLREDANQQYPTEGDCLNVGVKIYEGTEPQGTPRLKFCRS---HPPALISNGQAL 1769

Human  1713 T----LRFVSDSSISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPG 1773
            |    |:.|.:..    |.:.|:..|   ||..:....|.|.||.||..||||:||:|.:.:|.|
  Fly  1770 TVSVPLQLVEEFQ----GHYMTMDTS---CGSIYNALSGKFTSPYYPASYPPNIECLWLLEASMG 1827

Human  1774 NRLQLSFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHT---LWVRFISD 1835
            |.|.|:..|..||.|:.|:||::|:||.:.:|.|:|.||||..|    .:: |:   :|::|.||
  Fly  1828 NSLSLTLESMDLEKSESCNRDYLEVREESESGQLIGVYCGNEVP----GVI-HSRGAIWMKFKSD 1887

Human  1836 GSGSGTGFQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEM-DI 1899
            ....|.||.|::.....|: :.||.|.:.||.:|..:.....|.|.:.|:..:||...:|.: |:
  Fly  1888 DDNVGEGFMASYNYEHHNE-LNGTEGTIESPHFPSKFQDPVPYSWRITVDKEYVVAISLLYLRDL 1951

Human  1900 EEIQNCYYDKLRIYDGPS-IHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKG-FLLEWFA 1962
            ::      ..|..|||.| |.||:   ......|:..|:.|.:.|       .|.:| |.|.|..
  Fly  1952 DQ------PHLNFYDGYSDIGARI---EVTDPDETIISSTNVVYF-------TSNRGPFKLNWNR 2000

Human  1963 VD---------APDGVLPTIAPGACGGFLRTGDAPVFLF-SPGWPDSYSNRVDCTWLI----QAP 2013
            :.         |.:      ....||..|.|.|..|..| |||:|:.|...::|.|.:    .|.
  Fly  2001 LSKEALRSNRTAEE------RTRQCGNQLITIDRSVIGFHSPGYPNGYEQDLNCFWTLVPSNPAM 2059

Human  2014 DSTVELNILSLDIESHRTCAYDSLVIRDG-DNNLAQQLAVLCGREIPGPIRSTGE------YMFI 2071
            .:.:.|:.:.|:|.| ..|..|.:.|..| |.....:|..||..    |..|:..      |:.:
  Fly  2060 HAVLTLSQIDLEIFS-EDCIADYVKIFSGSDLQNWSELRTLCSL----PTESSDRVFHGRPYLRV 2119

Human  2072 RFTSDSSVTRAGFNASFHKSCGGYLHADRGIITSPKYPETYP-SNLNCSWHVLVQSGLTIAVHFE 2135
            .|.:|.||.:.|||.....:||..:.|.:|::...:..:..| .|.:|.|.:.|:.|..|.:.|.
  Fly  2120 EFVTDPSVNKTGFNGIVRTACGSEITASKGLVNITEILKVLPRPNHDCVWTIKVRQGRRIKIDFP 2184

Human  2136 QPFQIPN----GDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFI 2196
            . ||:.|    |.|.|.  :||:||||.|..||.|    |.|.:|.......|.||.|:.:::|
  Fly  2185 D-FQLQNNMASGSSDCR--NYLLLRNGNDEDSPFL----GRGKYCEDVVHEVLNTSSNKAYIKF- 2241

Human  2197 SDHSNEGQGFKIKYEAKSL--ACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRI 2259
              |......|.:.:..:.|  ...|.:.:..:....:::||.:||...||::||||:.||||.||
  Fly  2242 --HFASPPRFLVSFRFEELRYTDSGRIRLSASGDEQFISSPYYPHLPHPHSECIWIVEAPPEHRI 2304

Human  2260 QLQFEDRFD-IEVT---PNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDN 2320
            .|.|:..|| ::.|   ..|...::.:.||.....|.:.::||...|.:.:|:|..|.:|:.:|.
  Fly  2305 MLHFQGAFDMLDATGEPEECQREFVLINDGSTELRPEIGRYCGNRKPDTIYSTGNQMRIRYFTDV 2369

Human  2321 SPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLF----------CEWHLQ------- 2368
            |..|:||.|..|:|:|||......||:.|      |.||.|.          |.:.::
  Fly  2370 SEPHMGFNASLSVARCGGSFHSPEGVIAS------PSRDLLLIHEEGKQLQECVYTIELEKGSTI 2428

Human  2369 GLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSG-----NILG--RYCGNTIPDSIDTSSNTA 2426
            .|:..||.|.    .|:|.|..:::.:.:.:....|     .|:.  ..||......| :.:|..
  Fly  2429 DLTSEYLQIP----TLRNGSCSQRNHLMLEEMDAFGLDGEEKIVDTLMLCGMEAKHLI-SETNKI 2488

Human  2427 VVRF-VTDG-SVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRR 2489
            |.|: ..|| .....||||::.|....||..:..|:|...:|.||...||...|:|::..|:|||
  Fly  2489 VFRYRFLDGIPAENQGFRLKYTSLGSRCGETIYASVGVLQTPGYPLGVPHPMHCKWQVQVPKGRR 2553

Human  2490 ITLMFNNLRLATHPSCNNEHVIVFNG--IRSNSPQLEKLCSSVNVS--NEIKSSGNTM------- 2543
            :.|...:....|:......  :.|.|  ..:|..:::.:....||.  .|:.||.|||
  Fly  2554 VRLEILDFNTGTNMDLRGR--LGFRGRLTVANDFKMQSILGRYNVDPPAEVLSSDNTMGIDAFLL 2616

Human  2544 --------KVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCE 2600
                    |:.|...||....|||.......|.            .|..      .|.||.|:|.
  Fly  2617 PIVQNHGIKLRFSAYGSSSCPGFTVMMNEVADI------------QFQR------FNISRPLHCS 2663

Human  2601 WTLSNPNQGNSSISIHFEDFYLES------HQDCQFDVLEFRVGDADGPLMWR-LC-----GPSK 2653
            :.:..|:  ||::.|..:::...|      |.......|:|...:.:..||.| ||     .|.|
  Fly  2664 YKVVPPS--NSTLLIRVKEYNTTSVMMWNTHMCALLSPLKFNRLEQEEELMERILCDYQSPAPGK 2726

Human  2654 PTLPLVIPYSQVWIHFVTNERVEH--IGFHAKYSFTDCGGIQI---GDSGVITSP----NYPNAY 2709
            |...:.:|:.   |..|.:....:  ......||...|||:.|   ||:..:..|    :...|.
  Fly  2727 PLPSIRLPFP---IQLVVSASARNAMTNLVLSYSTQSCGGVIILEPGDNMTVHQPSGMVSAAGAI 2788

Human  2710 DSLTHCSSLLEAPQGHTITLTFSDFDIE-----------------PHTTCAWDSVTVRNGGSPES 2757
            |.........:| .|....|...|..:|                 |...|....:.|.||....|
  Fly  2789 DCAWAIGPYTDA-SGEDEVLVPQDIQLEVSVYNVNLPAPSPSAQSPEAPCLHHYLKVYNGPDQNS 2852

Human  2758 PIIGQYCGNSNP--RTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQT---LGCGG--IFHSDNGT 2815
            |.:|.:|..:..  ..::.|   |.:.::|| |....   ||:|...   .||||  ::     .
  Fly  2853 PSLGLFCNQATAVNMVVERG---LFLEYHSD-SFSAN---ATFNVSIKYGSGCGGKLVY-----P 2905

Human  2816 IRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKV---------WAGT 2871
            .|:..:.:.:..|..|.|........|:.::|...|.|....| |...::.|         |...
  Fly  2906 YRAIDFAEQYKNNVECIWEVEATMGYHIGLTFQGRFYIEDSPG-CTKDYLLVQQRNETTGNWTDL 2969

Human  2872 EEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFVSRCGSNFTGPS--GYIIS 2933
            :.:        ||.|||..:.|.|.....:|:|. :..|.||.|.|...||......|  ..:.|
  Fly  2970 QRI--------CGRVAPEMINTTSPYLRLIFRSDGDVVADGFLAKFERNCGGLLYADSTEQELAS 3026

Human  2934 PNYPKQYDNNMNCTYVIEANPLSV--VLLTFVSFHLEARSAVTGSCVNDGVHII---RGYSVMST 2993
            |.:|..|:..:.|.:.|.....|:  ||::||:|.||  ......|:.|.:.:.   :|.....|
  Fly  3027 PGFPNGYEKYLQCNWTIVPRSPSMGGVLVSFVNFDLE--QGPISVCLYDNLTVTTKDKGKDPQQT 3089

Human  2994 PFATVCGDEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYAD- 3057
               |:||.:..........|.|...::...:..||...|....|||:.:.:| ::.||. .:.|
  Fly  3090 ---TLCGVKHNHEYRGKEYVNLLLRTDGSYSGRGFTLLYTSRLCGGIISRTS-MVESPV-QHTDN 3149

Human  3058 -YPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPL------LGKFCGS 3115
             .|....|.:.:|........:||...|...:::|::|.:.::.|     |:      .|:|||
  Fly  3150 TLPPGSDCYWNLTAPAGYKFNIKFLFIDFEANSNCAYDGVEVFSG-----PIPDERYRWGRFCG- 3208

Human  3116 KRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGY------------LTGSNNTF 3168
                   ..|..:.|:    |....:|...||.....|.:|....            |.||:...
  Fly  3209 -------RINEDLPLI----SIPQERGIIHSFSDDRDPSRGFRALVRVMPNCDEKISLNGSSRYV 3262

Human  3169 ASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLA 3233
            .|..:::.| |..:|:|..:.....::.|.:.|:.|.::   ....|..|||:|.||....|::.
  Fly  3263 YSKFNNAGG-YQNDLDCQIVFRVNPDQQISVEFSNFHVQ---DTDGCRSDYVELRDGGGTFADII 3323

Human  3234 GTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGG---TYNATWTPQ-NISSP 3294
            |.|||...|....::.:.|.::|::|..:...||..|...:...||.   |.:|..|.: .|:||
  Fly  3324 GRFCGQNQPPTLRTTRHTLYMRFVTDNKVTDTGFQVTINAIPRLCGSSEITLSADGTKEVTINSP 3388

Human  3295 -NSSDPDVPFSI-CTWVIDSPPHQQVKITVWALQLTSQD--CTQNYLQL---QDSP---QGHGN- 3348
             .:...:.|..: |.|.|......:|:...:.|...:|:  |..:||::   :|:|   ||.|.
  Fly  3389 ARTPGGNYPNGVSCFWKIKGDSLLRVQFVNFDLHGPNQNGSCVDDYLKIYNSEDAPLLEQGLGTD 3453

Human  3349 ----------------SRFQFCGRNASAVP-VFYSSMSTAMVIFKSGVVNRNSRMSFTYQIA-DC 3395
                            :...:||   :..| ::|...|...:.|:|..:.::.  .|..|:| :.
  Fly  3454 LVFNGQTSSKNGFGFATEHVYCG---NVKPDIYYGRSSEVYLKFRSKGLEQHG--GFQLQVALNS 3513

Human  3396 NRDYHKAFGNLRSPGWPDNYD---------NDKDCTVTLTAPQNHTISLFFHSLGIENSVECRND 3451
            ||:.|              ||         ...||.:.:.||.|:|:||::..| |..:.:|..:
  Fly  3514 NRERH--------------YDGLQGRVHLSQSADCNIIIRAPPNYTLSLYYTEL-IFGTYDCEME 3563

Human  3452 FLEVRNGSNSNSPLLGKYCGTL-LPNPVFSQNNELYLRFKSDS-VTSDRGYEIIWTSSP----SG 3510
            .|||.:.:|.:   |.:.|..: :...:||..|||.|:.|:.| :||   .::.:.:||    .|
  Fly  3564 NLEVFDRTNRS---LQRVCSFVDMGKSLFSNANELRLQMKTGSYLTS---LDLTYLASPVEKGPG 3622

Human  3511 CGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGP 3575
            |||..|...|.|::|.||....||:.|:|::..|:..:|.:.|...::.....|..:||.:.:
  Fly  3623 CGGQFYNTEGIFSNPFYPNNVRNNSECQWIVRVPSNNVVFLTFEVFNLGSKTTCHTDYLQILE-- 3685

Human  3576 NASSPSSGP------YCGGDTSIAP--FVASSNQVFIKFH 3607
               ..::|.      :||.|.   |  :.:..:||.::||
  Fly  3686 ---QDATGEEREMRRFCGEDN---PKYYKSRRSQVLVRFH 3719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CUBN	NP_001072.2	Interaction with AMN. /evidence=ECO:0000269\|PubMed:30523278	42..49		1/6 (17%)
		EGF_CA	136..167	CDD:238011	14/30 (47%)
		EGF_CA	170..210	CDD:238011	23/39 (59%)
		EGF_CA	263..304	CDD:214542	21/42 (50%)
		EGF_3	309..347	CDD:289699	23/37 (62%)
		EGF_3	353..387	CDD:289699	12/33 (36%)
		EGF_CA	399..430	CDD:238011	12/32 (38%)
		EGF_CA	432..468	CDD:238011	13/37 (35%)
		CUB	474..585	CDD:238001	41/112 (37%)
		CUB	590..699	CDD:238001	48/109 (44%)
		CUB	708..815	CDD:238001	34/115 (30%)
		CUB	817..927	CDD:238001	32/117 (27%)
		CUB	932..1041	CDD:238001	42/115 (37%)
		CUB	1048..1157	CDD:294042	35/108 (32%)
		CUB	1165..1275	CDD:238001	35/112 (31%)
		CUB	1282..1388	CDD:238001	31/111 (28%)
		CUB	1391..1505	CDD:238001	39/113 (35%)
		CUB	1510..1617	CDD:238001	38/113 (34%)
		CUB	1620..1733	CDD:238001	33/128 (26%)
		CUB	1738..1847	CDD:238001	47/111 (42%)
		CUB	1859..1962	CDD:238001	29/105 (28%)
		CUB	1978..2088	CDD:278839	37/121 (31%)
		CUB	2092..2212	CDD:238001	38/124 (31%)
		CUB	2217..2333	CDD:238001	39/119 (33%)
		CUB	2336..2447	CDD:238001	32/136 (24%)
		CUB	2452..2564	CDD:238001	35/130 (27%)
		CUB	2570..2686	CDD:238001	26/129 (20%)
		CUB	2689..2800	CDD:238001	30/136 (22%)
		CUB	2805..2918	CDD:238001	29/124 (23%)
		CUB	2920..3034	CDD:238001	29/120 (24%)
		CUB	3037..3148	CDD:238001	26/118 (22%)
		CUB	3157..3273	CDD:238001	30/127 (24%)
		CUB	3278..3392	CDD:238001	31/145 (21%)
		CUB	3395..3506	CDD:238001	32/121 (26%)
		CUB	3511..3621	CDD:238001	28/105 (27%)
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011	14/33 (42%)
		EGF_CA	192..233	CDD:238011	23/40 (58%)
		EGF_CA	282..322	CDD:214542	21/41 (51%)
		EGF_3	328..366	CDD:289699	23/37 (62%)
		EGF	430..457	CDD:278437	11/26 (42%)
		EGF_CA	469..503	CDD:238011	13/33 (39%)
		CUB	509..622	CDD:238001	41/112 (37%)
		CUB	627..737	CDD:238001	49/111 (44%)
		CUB	744..849	CDD:294042	33/113 (29%)
		CUB	853..970	CDD:238001	32/119 (27%)
		CUB	978..1094	CDD:238001	42/116 (36%)
		CUB	1100..1211	CDD:238001	36/111 (32%)
		CUB	1216..1330	CDD:238001	36/113 (32%)
		CUB	1446..1549	CDD:238001	35/106 (33%)
		CUB	1554..1667	CDD:238001	38/112 (34%)
		CUB	1792..1899	CDD:238001	47/111 (42%)
		CUB	1910..1998	CDD:294042	28/103 (27%)
		CUB	2019..2133	CDD:238001	35/118 (30%)
		CUB	2140..2242	CDD:238001	36/111 (32%)
		CUB	2263..2379	CDD:238001	38/115 (33%)
		CUB	2385..2511	CDD:238001	32/136 (24%)
		CUB	2516..2630	CDD:238001	30/115 (26%)
		CUB	<2833..2892	CDD:294042	17/65 (26%)
		CUB	2898..3008	CDD:238001	28/123 (23%)
		CUB	3011..3127	CDD:238001	29/120 (24%)
		CUB	3130..3241	CDD:238001	29/129 (22%)
		CUB	3254..3363	CDD:238001	30/112 (27%)
		CUB	3379..3508	CDD:238001	27/133 (20%)
		CUB	3531..3601	CDD:294042	23/73 (32%)
		CUB	3623..3733	CDD:238001	28/105 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6916
eggNOG	1	0.900	-	-		E1_KOG4292
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37434
Inparanoid	1	1.050	1398	1.000	Inparanoid score	I120
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46457
OrthoDB	1	1.010	-	-		D3206at33208
OrthoFinder	1	1.000	-	-		FOG0006182
OrthoInspector	1	1.000	-	-		otm41483
orthoMCL	1	0.900	-	-		OOG6_106358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5821
SonicParanoid	1	1.000	-	-		X4462
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770