DRSC/TRiP Functional Genomics Resources

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Protein Alignment MLLT10 and NTO1

DIOPT Version :10

Sequence 1:NP_001182555.1 Gene:MLLT10 / 8028 HGNCID:16063 Length:1068 Species:Homo sapiens
Sequence 2:NP_015356.1 Gene:NTO1 / 856143 SGDID:S000006235 Length:748 Species:Saccharomyces cerevisiae


Alignment Length:355 Identity:104/355 - (29%)
Similarity:152/355 - (42%) Gaps:70/355 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    11 EDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCE-SQ 74
            :|....||.:   .|.||........|.:|:||  ||.:||||.||||:.:|.|.|.||:|. |:
Yeast   255 DDGTGLSMDQ---ACAVCLGTDSDNLNTIVFCD--GCDIAVHQECYGIIFIPEGKWLCRRCMISK 314

Human    75 ERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIV-LQSVPHDRYNKTCY 138
            ...|  .|.:||...||.|:||.|.|.|.:|||::||:.|:|:..||||. :|:|...|:...||
Yeast   315 NNFA--TCLMCPSHTGAFKQTDTGSWVHNICALWLPELYFSNLHYMEPIEGVQNVSVSRWKLNCY 377

Human   139 ICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLL-----C--EEEGNGADNVQYC--GYC 194
            ||       |...|||:.|.:..|..|:|||||:.|||.     |  :|..:...:.:|.  .:|
Yeast   378 IC-------KKKMGACIQCFQRNCFTAYHVTCARRAGLYMSKGKCTIQELASNQFSQKYSVESFC 435

Human   195 KYHFSK-LKKSKRGSN--RSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSP--- 253
            ..|..: .:.|..|.|  |.|...||...:.: .:|:|...:...:.:|...|...|...:|   
Yeast   436 HKHAPRGWQTSIEGINKARKYFSLLSTLQTET-PQHNEANDRTNSKFNKTIWKTPNQTPVAPHVF 499

Human   254 ---------------------------ALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTN 291
                                       ::...||..|..| ....|||:....:....|...|.|
Yeast   500 AEILQKVVDFFGLANPPAGAFDICKYWSMKRELTGGTPLT-ACFENNSLGSLTEEQVQTRIDFAN 563

Human   292 ANFQE----------VSAHTSSGKDVSETR 311
            ...::          |...|.:...:|.:|
Yeast   564 DQLEDLYRLKELTTLVKKRTQASNSLSRSR 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MLLT10NP_001182555.1 PHD_AF10_AF17 24..71 CDD:277049 22/46 (48%)
ePHD_AF10 78..206 CDD:277178 51/138 (37%)
Self-association 80..287 70/249 (28%)
Required for interaction with histone H3. /evidence=ECO:0000269|PubMed:26439302 106..190 34/91 (37%)
Interaction with FSTL3. /evidence=ECO:0000269|PubMed:17868029 141..233 29/103 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..260 12/85 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..505 5/31 (16%)
DNA-binding 311..674 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 583..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..708
Transactivation domain, required for DOT1L-binding 703..784
CC_AF10 715..778 CDD:411015
Leucine-zipper 750..778
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..865
NTO1NP_015356.1 COG5141 18..748 CDD:227470 104/355 (29%)
Blue background indicates that the domain is not in the aligned region.

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