Protein Alignment MLLT10 and mllt10

DIOPT Version :10

• Sequence 1: NP_001182555.1
• Gene: MLLT10 / 8028
• HGNCID: 16063
• Length: 1068
• Species: Homo sapiens
• Sequence 2: XP_017209395.2
• Gene: mllt10 / 492342
• ZFINID: ZDB-GENE-041114-176
• Length: 1162
• Species: Danio rerio
• Alignment Length: 1201
• Identity: 623/1201 - (51%)
• Similarity: 764/1201 - (63%)
• Gaps: 197/1201 - (16%)

Human     1 MVSSDRPVSLEDEVSHS-MKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTG 64
            ||||:..::.||:.|.| ||||||||||||||||||||||||||||||:||||||||||||||||
Zfish    26 MVSSELYLAEEDDDSPSNMKEMIGGCCVCSDERGWAENPLVYCDGHGCNVAVHQACYGIVQVPTG 90

Human    65 PWFCRKCESQERAAR------------------------------------------VRCELCPH 87
            |||||||||||||||                                          |||||||.
Zfish    91 PWFCRKCESQERAARVIKGWRGRKPSWQTPEGGGQSTTCNKEEEDSRLSRSLKTLNIVRCELCPQ 155

Human    88 KDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATG 152
            |||||||||||||||||||||||||:|||||||||||||||||:|||||||||:|||||||||||
Zfish   156 KDGALKRTDNGGWAHVVCALYIPEVEFANVSTMEPIVLQSVPHERYNKTCYICEEQGRESKAATG 220

Human   153 ACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSK-RGSNRSYDQSL 216
            ||||||||||||||||||||.|||||||:|:.||||:||||||||::||::|| |||..   |||
Zfish   221 ACMTCNKHGCRQAFHVTCAQLAGLLCEEQGSDADNVKYCGYCKYHYNKLRRSKGRGSRA---QSL 282

Human   217 SDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSN----NSISG 277
            ||||:||.||||:|||||:||:|:||.||||..|.||:|||:|.||.||:|.::|:    :|||.
Zfish   283 SDSSTHSLDKHHDKEKKKHKERDRHKPKHKKPLELSPSLVPALMVTPEKSYNNSSSGGSVSSISS 347

Human   278 SLKRLEDTTARFTNANFQEVSAH-TSSGKD--VSETRGSEGKGKKSS---AHSSGQRGRKPGGGR 336
            :.|||:|:.|||||||||||..| :||.||  .|:.:.|:.|.||||   :.|||.||||...|:
Zfish   348 TQKRLDDSGARFTNANFQEVPPHSSSSSKDGGSSDGKSSDSKSKKSSHSTSSSSGSRGRKSVAGK 412

Human   337 NPG---------TTVSAASPFPQGSFSGTPGSVKS-SSGSSVQSPQDFLSFTDSDLR-NDSYSHS 390
            ..|         |..|:.|||.||...|:..|.|| :|||.||...|||||:|..|| .|||:
Zfish   413 PHGPVVTTATSSTAPSSTSPFQQGHLLGSNSSSKSATSGSVVQPTSDFLSFSDPSLRAGDSYT-- 475

Human   391 QQSSATKDVHKG--ESGSQEG--GVNSFSTLIGLPSTSAVTSQPKSFEN--SPGDLGNSSLPTAG 449
             ..|..:...||  |||:.|.  .:|:|| :|.| |.|:.:|..|.:||  :.|:||  ||.:|.
Zfish   476 -PPSFGRCHMKGGAESGASESMVALNTFS-MIPL-SQSSSSSSSKHYENCHTTGELG--SLASAS 535

Human   450 YKRAQ----------TSGIEEETVKEKKRKGNKQSKHGP-GRPKGNKNQENVSHLSV--SSASPT 501
            |||.|          :|...|:.||:||| ||.::::|| ...:.:|..:...|:|.  ||.||:
Zfish   536 YKRPQPSSSSSSATSSSSTGEDGVKKKKR-GNWRNRYGPCFTTQDSKTTDAGEHISTMPSSTSPS 599

Human   502 --------------SSVAS--AAGSITSS-SLQKSPTLLRNGSLQSLSVGSSP-VGSEISMQYRH 548
                          ||.||  |.|:.||| .:||||:||||||||.::|.|.| |..|....|.
Zfish   600 PSSMSNMVCRGSTVSSTASVGAVGAGTSSLGIQKSPSLLRNGSLQGMTVSSPPAVPGEQKRSYP- 663

Human   549 DGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPS 613
                                 :|:|||...|:.|.|...|  .|:|.||...|..:..:..|  :
Zfish   664 ---------------------SSSDVACPLPSAVLGGSMS--ASNSELPAHQSVVVTSMPTL--T 703

Human   614 AVSSAAPAVAT--TQANTLSGSSLSQAPSHMYGNR--SNSSMAALIAQSENNQTDQDLGDNSRNL 674
            ::.||||..:|  |.||:|.| |.:.|||||:|||  .||:|||||||||.:..||:|||.:...
Zfish   704 SLPSAAPFTSTPSTHANSLPG-SFNLAPSHMFGNRLNPNSAMAALIAQSEGSPADQELGDGALGF 767

Human   675 VGRGSSPRGSLSPRSPVSSLQIRYDQ----PG-NSSLENLPPVAASIEQLLERQWSEGQQFLLEQ 734
            ..||:||:.:||||||:|.|.||||.    || .|..:.|||.|.||:|||||||:|||||||:|
Zfish   768 SRRGNSPKTNLSPRSPLSGLHIRYDAGPMVPGLGSGSDTLPPAATSIDQLLERQWNEGQQFLLQQ 832

Human   735 GTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPF----PTITANPSPSHQI 795
            |:..|:|.|||||||||||||||||||:.||.||||||||:|||||||    .|.|...||.:..
Zfish   833 GSQGDVLAMLKSLHQLQVENRRLEEQIRTLTMKKERLQLLSAQLSVPFTPASTTATTASSPMYPS 897

Human   796 HTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQST-SSSSALSTPPPAGQSPAQ 859
            :|.       ||.|: |||..:| |.|.::|.|:..||..|.|.|: ||:|:|||||.|..||.|
Zfish   898 NTH-------TDMLH-SKSIQLG-SVLTESSQPLPTQDPQSGGHSSGSSTSSLSTPPSAAHSPPQ 953

Human   860 QGSGVSGVQQVNGVTVGALASGMQP--VTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQT 922
                    |||||  ||.....:||  ..|::||::.|.|::|||.||.||::|||||||||:||
Zfish   954 --------QQVNG--VGMAGVPVQPGNANSSLPAIAGVTGLMGALQGNHLAMSGIVGALNGVIQT 1008

Human   923 -PVTMSQNPTPLTHTTVPPNATHPMPATLTNSA---SGLGLLSDQQRQILIHQQQFQQLLNSQQL 983
             ..:::||.:||..:....:|:..|.::||||:   :...|.::|.||||:||.|.|||..|||.
Zfish  1009 SQSSLTQNSSPLPQSATASSASLSMSSSLTNSSMSTTKTRLFTEQHRQILLHQHQLQQLFGSQQP 1073

Human   984 TPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQIPINNLLAGTQAPPLHTATTNPFLTIHGDN 1048
            ||||.|..||||||...||..|.:...:|.   .|:|||:||.|.|.    |.:|||||..|.||
Zfish  1074 TPEQQQVLLYQLMQQQQQQQQQQQQNDIQF---QQLPINSLLPGNQP----TTSTNPFLAHHNDN 1131

Human  1049 ----------ASQKVARLSDKTGPV-AQEKS 1068
                      |.::..||.:|..|| .|||:
Zfish  1132 NTPKAGVNTAAIKQTKRLGEKAVPVTGQEKT 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MLLT10	NP_001182555.1	PHD_AF10_AF17	24..71	CDD:277049	45/46 (98%)
		ePHD_AF10	78..206	CDD:277178	115/170 (68%)
		Self-association	80..287		163/211 (77%)
		Required for interaction with histone H3. /evidence=ECO:0000269|PubMed:26439302	106..190		76/83 (92%)
		Interaction with FSTL3. /evidence=ECO:0000269|PubMed:17868029	141..233		73/92 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..260		36/53 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..505		103/263 (39%)
		DNA-binding	311..674		164/417 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..612		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..708		24/52 (46%)
		Transactivation domain, required for DOT1L-binding	703..784		61/84 (73%)
		CC_AF10	715..778	CDD:411015	50/62 (81%)
		Leucine-zipper	750..778		23/27 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..865		28/65 (43%)
mllt10	XP_017209395.2	PHD_AF10_AF17	50..97	CDD:277049	45/46 (98%)
		ePHD_AF10	148..273	CDD:277178	111/124 (90%)
		CC_AF10	813..876	CDD:411015	50/62 (81%)