Protein Alignment MLLT10 and nto1

DIOPT Version :10

• Sequence 1: NP_001182555.1
• Gene: MLLT10 / 8028
• HGNCID: 16063
• Length: 1068
• Species: Homo sapiens
• Sequence 2: NP_596378.1
• Gene: nto1 / 2540077
• PomBaseID: SPBC17D11.04C
• Length: 767
• Species: Schizosaccharomyces pombe
• Alignment Length: 194
• Identity: 69/194 - (35%)
• Similarity: 100/194 - (51%)
• Gaps: 20/194 - (10%)

Human     7 PVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKC 71
            ||.:|||:.       |.|.:|::......|.:|:||  .|:.:|||.||||..||.|.|||:||
pombe   186 PVRVEDELD-------GRCVICNEAECENSNAIVFCD--NCNTSVHQNCYGIPFVPEGQWFCKKC 241

Human    72 ESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPI-VLQSVPHDRYNK 135
            ....... :.|..||.:|||...|.:|.|.|.:||:.|||:.|.:.|.::.: .:.|:|..|:..
pombe   242 LLAPHEV-ICCAFCPDRDGAFCTTLDGRWCHTICAIAIPEISFHDTSRLDLVRNIASIPKSRWKL 305

Human   136 TCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGA--DNVQYCGYCKYH 197
            .|.||       |...|.|:.|:...|..|:|:|||:.||...:...:.|  |:|....||..|
pombe   306 VCCIC-------KLRWGTCVQCSDKNCYAAYHITCARRAGFFYKIYSHSASYDSVDMETYCDKH 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MLLT10	NP_001182555.1	PHD_AF10_AF17	24..71	CDD:277049	20/46 (43%)
		ePHD_AF10	78..206	CDD:277178	41/123 (33%)
		Self-association	80..287		41/121 (34%)
		Required for interaction with histone H3. /evidence=ECO:0000269|PubMed:26439302	106..190		27/86 (31%)
		Interaction with FSTL3. /evidence=ECO:0000269|PubMed:17868029	141..233		18/59 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..260
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..505
		DNA-binding	311..674
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..708
		Transactivation domain, required for DOT1L-binding	703..784
		CC_AF10	715..778	CDD:411015
		Leucine-zipper	750..778
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..865
nto1	NP_596378.1	COG5141	1..685	CDD:227470	69/194 (36%)