Protein Alignment MLLT10 and mllt10

DIOPT Version :10

• Sequence 1: NP_001182555.1
• Gene: MLLT10 / 8028
• HGNCID: 16063
• Length: 1068
• Species: Homo sapiens
• Sequence 2: XP_012821091.1
• Gene: mllt10 / 100036598
• XenbaseID: XB-GENE-6408100
• Length: 1025
• Species: Xenopus tropicalis
• Alignment Length: 1092
• Identity: 736/1092 - (67%)
• Similarity: 849/1092 - (77%)
• Gaps: 91/1092 - (8%)

Human     1 MVSSDRP--VSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPT 63
            |||.: |  |:.|:|:..|||||||||||||||||||||||||||||||:|||||||||||||||
 Frog     1 MVSGE-PVVVAAEEELPTSMKEMIGGCCVCSDERGWAENPLVYCDGHGCNVAVHQACYGIVQVPT 64

Human    64 GPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSV 128
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    65 GPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSV 129

Human   129 PHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGY 193
            ||:|||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
 Frog   130 PHERYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQLAGLLCEEEGNGADNVQYCGY 194

Human   194 CKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPS 258
            ||||:|||                                |:|||:||:||.:||.||.||||||
 Frog   195 CKYHYSKL--------------------------------KHKEKEKHRQKSRKQMEPLPALVPS 227

Human   259 LTVTTEKTYT---STSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKS 320
            ||||||||||   |.:|||:..|:||:|||:||||||||||||.|.:|.|:..|.|.||.||||:
 Frog   228 LTVTTEKTYTCSSSNNNNSVPSSVKRIEDTSARFTNANFQEVSTHPTSVKEALEARSSEIKGKKA 292

Human   321 SAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRND 385
            ::|.:.|||||...|||...:.:|.|||.|..|||||.||||||||||||||:|||||:.::|.:
 Frog   293 ASHITLQRGRKSSSGRNCAGSATATSPFQQAHFSGTPSSVKSSSGSSVQSPQEFLSFTEFEVRTE 357

Human   386 SYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGY 450
            ||.||||.::|||..||::|.|||.:||||:|||||:...::.|.|::|:.|||..||||..|||
 Frog   358 SYHHSQQLTSTKDAPKGDTGLQEGTINSFSSLIGLPTNPPLSFQTKNYESVPGDYVNSSLTVAGY 422

Human   451 KRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSS 515
            ||.|:|.::|:||||||||||||:||||||||||||||.:||||.||||||||||||||||.||.
 Frog   423 KRLQSSVLDEDTVKEKKRKGNKQNKHGPGRPKGNKNQETLSHLSASSASPTSSVASAAGSIASSV 487

Human   516 LQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPN 580
            :|:|||||||||||||||||||.||.                         .:.|.|||..|||:
 Frog   488 IQRSPTLLRNGSLQSLSVGSSPGGSA-------------------------SLCNCNDVPTSFPS 527

Human   581 VVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGN 645
            .:  |||||||||||:||.::.||||..:.|||::::.......||.::|.||||:.:.||.||.
 Frog   528 AL--SGSSTPVSSSHIPQPAAAHLQQEVSSSPSSLATVPANTVATQVSSLPGSSLAMSSSHTYGR 590

Human   646 RSNSSMAA--LIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPR-----------SPVSSLQI- 696
            |.|.:.||  |...|||.|.|||..|::|||..:|:|||||:|||           ||::||..
 Frog   591 RLNPTSAAGTLPVPSENAQPDQDAVDHNRNLPAKGASPRGSISPRLNIYGVGSDKISPLNSLATS 655

Human   697 RYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQI 761
            |::..||||||::||.|.|||||||||||||||||.||||.||||||||||||||||||||||||
 Frog   656 RFEPSGNSSLESVPPAATSIEQLLERQWSEGQQFLQEQGTSSDILGMLKSLHQLQVENRRLEEQI 720

Human   762 KNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNS 826
            ||||||||||||||||||||||||::||:.|.|:||:..|....:||||.|||||:|| |..||:
 Frog   721 KNLTAKKERLQLLNAQLSVPFPTISSNPNTSPQVHTYPLQNVSNSDSLNISKSPHLGN-FQLDNA 784

Human   827 LPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPA 891
            |||.||:||||||||||||:||||||.|||||||   |.||.::|||.:|||.||:|.||..:|.
 Frog   785 LPVPNQELTSSGQSTSSSSSLSTPPPDGQSPAQQ---VQGVHRINGVAMGALTSGIQSVTQALPN 846

Human   892 VSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASG 956
            |::||.||||||.|||:||  .||||||||.|..:.|. ..|||.::.||.|||:.::|.|||||
 Frog   847 VASVGAIIGALPANQLSIN--FGALNGVMQNPANLPQT-AALTHGSILPNVTHPITSSLANSASG 908

Human   957 LGLLSDQQRQILIH--QQQFQQLLNSQQLTPEQHQAFLYQLMQHHH---QQHHQPELQQLQIPGP 1016
            ||||:|||||:|:|  |||||.:|||||||||||..|||||||.||   |||||||||||||||.
 Frog   909 LGLLTDQQRQLLLHQQQQQFQHILNSQQLTPEQHHTFLYQLMQQHHQQQQQHHQPELQQLQIPGA 973

Human  1017 TQIPINNLLAGTQAPPLHTATTNPFLTIHGDNASQKVARLSDKTGPVAQEKS 1068
            .|:|:|:||||.||.|||:.||||||.:|||.|:|||:||.||:|||.|:||
 Frog   974 AQLPLNSLLAGAQAAPLHSTTTNPFLALHGDTAAQKVSRLGDKSGPVLQDKS 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MLLT10	NP_001182555.1	PHD_AF10_AF17	24..71	CDD:277049	45/46 (98%)
		ePHD_AF10	78..206	CDD:277178	121/127 (95%)
		Self-association	80..287		157/209 (75%)
		Required for interaction with histone H3. /evidence=ECO:0000269|PubMed:26439302	106..190		81/83 (98%)
		Interaction with FSTL3. /evidence=ECO:0000269|PubMed:17868029	141..233		59/91 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..260		18/53 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..505		138/213 (65%)
		DNA-binding	311..674		210/364 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..612		17/28 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..708		28/59 (47%)
		Transactivation domain, required for DOT1L-binding	703..784		74/80 (93%)
		CC_AF10	715..778	CDD:411015	60/62 (97%)
		Leucine-zipper	750..778		27/27 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..865		45/64 (70%)
mllt10	XP_012821091.1	PHD_AF10_AF17	25..72	CDD:277049	45/46 (98%)
		ePHD_AF10	79..207	CDD:277178	123/159 (77%)
		CC_AF10	674..737	CDD:411015	60/62 (97%)