DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCUBE1 and clec-78

DIOPT Version :9

Sequence 1:NP_766638.2 Gene:SCUBE1 / 80274 HGNCID:13441 Length:988 Species:Homo sapiens
Sequence 2:NP_500454.2 Gene:clec-78 / 185915 WormBaseID:WBGene00018547 Length:3514 Species:Caenorhabditis elegans


Alignment Length:1205 Identity:251/1205 - (20%)
Similarity:378/1205 - (31%) Gaps:482/1205 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    35 DECSEGTDDCHIDAICQNTP--KSYKCLCKPGYKGEGKQCEDI-DEC--ENDYYNGG-CVHECIN 93
            |||: |. .|....:|.:.|  ||..|||:.|:  .|.|||:| |.|  .|...||. |:.|.: 
 Worm  2091 DECN-GV-KCPNGGVCHDLPGVKSTTCLCRTGF--AGPQCEEITDICSTNNPCRNGARCIGEKL- 2150

Human    94 IPGNYRCTCFDGFMLAHDGHNC-LDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCI 157
              |.::|.|..|:    :|.|| .::|:|.|:.......||:.:..|:|:|.:||          
 Worm  2151 --GRFKCQCVPGW----EGPNCDKNIDDCADSPCALNATCVDLINDYKCECPTGF---------- 2199

Human   158 HRSNEGMNCMNKDHGCAH------IC------RETPKGGVACDCRPGF---DLAQNQKDCTLTCN 207
                .|..|..|::.||.      :|      |:       |.|:||:   :..||..:|..:  
 Worm  2200 ----SGKRCHIKENLCASSPCVHGLCIDKLYSRQ-------CLCQPGWTGENCDQNIDECAAS-- 2251

Human   208 YGNGGCQH--SCEDTDTGPTCGCHQKYALHSDGRTC---IETCAVNNGGCDRTCKDTATGVRCSC 267
                .||:  .|.|...|..|.|...|    :|..|   ::.||......:.||.:......|.|
 Worm  2252 ----PCQNDAKCIDEINGYMCECADGY----EGVHCQHLVDHCAKQPCHNNATCTNMGATYHCDC 2308

Human   268 PVGFTLQPDGKTCK-DINECLVNNGGCDHF----CRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327
            .:||    ||..|: :|:||..|.  ||..    ||:.|..|:|.|:.||   |..|.....|:|
 Worm  2309 TLGF----DGVHCEMNIDECAENQ--CDKLGTESCRDAVNDFKCVCKPGY---TGPRCDVKQDQC 2364

Human   328 SFERTC--DHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSC------DQG-CVNTKGS 383
            : :..|  |..|::..|:::|:|..|:         ...:|...||||      :.| ||:....
 Worm  2365 A-DSPCLNDAQCVDMGGAYKCVCKSGW---------TGPKCEQDNGSCAAKPCRNNGFCVSLVAD 2419

Human   384 YECVCPP---------------GRRLHWNGKDCVETGKCLSRA-----------------KTSPR 416
            |.|||||               |:..| ||.:|.:.|..|..|                 ||...
 Worm  2420 YFCVCPPGVSGKNCESAPNRCIGQPCH-NGGECGDFGSHLECACPASFTGKGCEFKNTGCKTCEN 2483

Human   417 AQLSCSKAGGVESCFLS-------------------CPAHTLFVPDSENSYVLSC--GVPGPQGK 460
            .......|||::.|..|                   ||:....| |..|:::..|  .:.|....
 Worm  2484 GGKCAEAAGGLQKCECSPGFTGERCETNIDECSTAHCPSGATCV-DQVNTHICVCPFNLTGVHCD 2547

Human   461 ALQKRNGTSSGLGPSCSDAPTTPIKQKARFKIRDAKCHL-------RPHSQA----------RAK 508
            .:...|.....|.|.   .||: ....|.|:|..:...:       :||..|          .::
 Worm  2548 KMINTNYDLQFLDPF---RPTS-ASLYAPFRIESSALSVGLWVKFEKPHQHAAFFSLHRFDNSSQ 2608

Human   509 ETAR------------------QPLLDHCH---------------------VTFVTLKCDSSKKR 534
            |..|                  .||....|                     |.:.:|:..|:...
 Worm  2609 EYVRVSSNLVRLTLFPGLAAVEVPLSSSQHLNNGKWNHLLITWQSKTGAYSVIWNSLRTYSNNGY 2673

Human   535 RRGRK--------------------------------------------SPSKEV-SHITAEFEI 554
            ..|::                                            ..|:|: ..:...||.
 Worm  2674 ATGKQLDVMTGITLGSTALPSFVGSIARVGVWNRVIDFEEELPLMVQHCQRSEEIYKGLLVRFEG 2738

Human   555 ETK--------------MEEAS-----------DTCEADCLRKRAEQ------------SLQAAI 582
            .||              :||.|           :.|.:|.:....::            |..:.|
 Worm  2739 FTKIIGRVERTHKSTCGVEEKSAMQKSQSQILIEDCPSDMVISSMDRETNVTWPEPTFLSSNSKI 2803

Human   583 KTLRKSIGRQQFYVQVSGTEYEVAQRPAKALEGQGACGAGQVLQDSKCV---------------- 631
            :.:.|::.:.|.:   :..||:|..........|..|.....:....||                
 Worm  2804 EKIEKNLKQGQMF---TWGEYDVLYTATDNATNQAQCNFKIRVGKENCVDAADPVNGVQSCESWG 2865

Human   632 ------AC------------------------------GPGTHFGGELGQCVSCMPGT----YQD 656
                  ||                              .|.|.|  ...||...:|.|    .:.
 Worm  2866 PQLKYKACSVECRDGFEFPRSPAVFYTCAADGKWKPNKSPSTMF--RYPQCTKHVPATKVVIVRI 2928

Human   657 MEGQL-SCTP-----------------------CPSSDGLGLPGARNVSECGGQ----------- 686
            :.|.. :||.                       |..:|..|..|.:...||||.           
 Worm  2929 IYGSSPACTESSKEAFTQKVQQTIDAIDSKWKMCSLTDANGCVGTQVRVECGGSKLPEEGRRRRR 2993

Human   687 ----------------------------------------------------------------- 686
                                                                             
 Worm  2994 NPESVLASSFGVEIEIPVKRRMLVDPSSGLETTIRDALHNEILSGVLNFEKVLPNGRPDVGSLKI 3058

Human   687 -------------------CSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTT 732
                               |:||.:.:.....|:.||:|.|||...||.||.|..|.:|..||..
 Worm  3059 KEEYLCQAGQVVVRDLCVPCAPGTYHSAATGECELCPIGEYQPLTARTECFKCAPGQITASEGAI 3123

Human   733 SFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQH 797
            |..:|  |.:|.|||.|::.|..|:.|..|.|||..|...||.|....:|..:.:|:...|:::.
 Worm  3124 SEGEC--KDNCPPGHQYDSLTSDCVTCGYGYYQPSAGAFECIPCGIGKTTLSEFATSEDECRDEC 3186

Human   798 CGGELGDYTGYIESPNYPGDYPANAECVWHIAPPP 832
            ..||....:|..: |...|.|.:..|....:|.||
 Worm  3187 PDGEQLSASGVCQ-PCQIGTYRSRGENKKCVACPP 3220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCUBE1NP_766638.2 EGF_3 37..72 CDD:289699 12/36 (33%)
FXa_inhibition 84..115 CDD:291342 9/31 (29%)
FXa_inhibition 121..156 CDD:291342 9/34 (26%)
FXa_inhibition 166..202 CDD:291342 12/50 (24%)
FXa_inhibition 206..241 CDD:291342 9/36 (25%)
FXa_inhibition 245..280 CDD:291342 10/34 (29%)
FXa_inhibition 286..321 CDD:291342 14/38 (37%)
vWFA <318..354 CDD:294047 10/37 (27%)
FXa_inhibition 366..401 CDD:291342 18/56 (32%)
GCC2_GCC3 636..683 CDD:285001 13/74 (18%)
GCC2_GCC3 690..737 CDD:285001 18/46 (39%)
GCC2_GCC3 746..793 CDD:285001 16/46 (35%)
CUB 798..909 CDD:238001 10/35 (29%)
clec-78NP_500454.2 CLECT 48..179 CDD:214480
LDLa 183..217 CDD:238060
CUB 234..333 CDD:214483
CUB 340..447 CDD:238001
CUB 460..562 CDD:214483
CCP 629..686 CDD:153056
CCP 690..746 CDD:153056
CCP 751..805 CDD:153056
EGF_CA 806..845 CDD:214542
FXa_inhibition 974..>1000 CDD:291342
CCP 1037..1092 CDD:153056
Sushi 1172..1232 CDD:278512
FA58C 1288..1428 CDD:238014
FA58C 1297..1429 CDD:214572
DUF5011 1455..1539 CDD:295940
HYR 1540..1621 CDD:280629
GCC2_GCC3 1862..1901 CDD:285001
GCC2_GCC3 1908..1958 CDD:285001
GCC2_GCC3 1965..2012 CDD:285001
EGF_CA 2091..2127 CDD:238011 15/39 (38%)
EGF_CA 2131..2166 CDD:238011 12/41 (29%)
EGF_CA 2169..2204 CDD:238011 11/48 (23%)
EGF_CA 2244..2280 CDD:238011 11/45 (24%)
EGF_CA 2283..2318 CDD:238011 10/38 (26%)
EGF_CA 2320..2357 CDD:238011 15/41 (37%)
EGF_CA 2362..2396 CDD:238011 9/43 (21%)
EGF_CA <2406..2434 CDD:238011 9/27 (33%)
EGF_CA 2511..2546 CDD:238011 7/35 (20%)
LamG 2558..2713 CDD:304605 19/158 (12%)
DUF5011 <2787..2843 CDD:295940 9/58 (16%)
GCC2_GCC3 3081..3128 CDD:285001 18/46 (39%)
GCC2_GCC3 3135..3182 CDD:285001 16/46 (35%)
GCC2_GCC3 3193..3235 CDD:285001 8/29 (28%)
GCC2_GCC3 3243..3290 CDD:285001
EGF_3 3296..3336 CDD:289699
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 47 1.000 Domainoid score I8890
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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