Protein Alignment STAM and Hrs

DIOPT Version :10

• Sequence 1: NP_003464.1
• Gene: STAM / 8027
• HGNCID: 11357
• Length: 540
• Species: Homo sapiens
• Sequence 2: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Alignment Length: 705
• Identity: 152/705 - (21%)
• Similarity: 228/705 - (32%)
• Gaps: 230/705 - (32%)

Human     9 FDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACV 73
            ||:::|.|||.:....||..||.|||::.|....||:...:|.:::|..:||.:..:|.:|.:.|
  Fly     6 FDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIV 70

Human    74 SNCGKIFHLEVCSRDFASEVSNVL-NKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKE 137
            .|||...|.||.:::.....|:.| :..|..|.:|:..|:..|...|::..:...|...:..||.
  Fly    71 KNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKA 135

Human   138 QGVTFPAI---------------------------------------------GSQAAEQ----- 152
            :|.|||.:                                             |...|:|
  Fly   136 KGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPK 200

Human   153 --------------------------AKASP-------------ALVAKDPGTVANK-----KEE 173
                                      ||:.|             :.:|:...|.|.|     |||
  Fly   201 YGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKEE 265

Human   174 EDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTN-------------HQHEGRKVRAIYDFEAAE 225
            |:|..|:.||..|..||...|.:|.|:...:...             ||..          |.|.
  Fly   266 EELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQP----------EEAT 320

Human   226 DNELT----------FKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKK 280
            :.||.          .|..|..::...|.|:... .|.|...:.|....:||.....|.....:.
  Fly   321 NPELAKYLNRSYWEQRKISESSSMASPSAPSPMP-PTPQPQQIMPLQVKSADEVQIDEFAANMRT 384

Human   281 TVQ---------------FSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDD-------- 322
            .|:               .|:|..|:|:       |:....:..  |.|......||
  Fly   385 QVEIFVNRMKSNSSRGRSISNDSSVQTL-------FMTLTSLHS--QQLSYIKEMDDKRMWYEQL 440

Human   323 QPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMY--- 384
            |..|.::....|...|:.....|||..|..:...  :..:::.:.|.:..|...|   |..|
  Fly   441 QDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQER--QRQMQMAQKLDIMRKKKQE---YLQYQRQ 500

Human   385 ---AKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAGNAQMSHLQSYSLPPEQLSSLSQAVVPPS 446
               .::|.|...||                   |.....:..:|...|.||       ...:|||
  Fly   501 LALQRIQEQEREMQ-------------------LRQEQQKAQYLMGQSAPP-------FPYMPPS 539

Human   447 ANP--ALPSQQTQAAYPNTMVSSVQGNTYPSQAPVYSP---------PPAATAAAATADV----- 495
            |.|  ..||.|....| |...:.|.|  |..|.|..:|         ||.....|....:
  Fly   540 AVPQHGSPSHQLNNVY-NPYAAGVPG--YLPQGPAPAPNGHGQFQAIPPGMYNPAIQQPMPPNLQ 601

Human   496 ---TLYQNAGPN----MPQVPNYNLTSS-----TLPQPGGSQQPPQ-PQQPYSQK 537
               .:.|.|.|.    ||.:|.....::     .|||.....|||| |.||..|:
  Fly   602 PGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPPQIPFQPQPQQ 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAM	NP_003464.1	VHS_STAM1	9..139	CDD:340797	40/130 (31%)
		SH3_STAM1	213..267	CDD:212897	11/63 (17%)
		GAT_STAM1	301..377	CDD:410594	15/83 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..540		16/48 (33%)
Hrs	NP_525099.3	VHS_Hrs	4..141	CDD:340771	42/134 (31%)
		FYVE_Hrs	157..217	CDD:277260	3/59 (5%)
		GAT_Hrs	376..471	CDD:410592	19/103 (18%)
		PABP-1234	<501..641	CDD:130689	37/168 (22%)