Protein Alignment EDEM3 and alpha-Man-Ib

DIOPT Version :10

• Sequence 1: NP_001306889.1
• Gene: EDEM3 / 80267
• HGNCID: 16787
• Length: 948
• Species: Homo sapiens
• Sequence 2: NP_651667.1
• Gene: alpha-Man-Ib / 43436
• FlyBaseID: FBgn0039634
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 490
• Identity: 142/490 - (28%)
• Similarity: 239/490 - (48%)
• Gaps: 80/490 - (16%)

Human    48 EKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFS-------L 105
            |:|   :.|:..|.|::..|.::|:..|.|.|::                    ::|       |
  Fly   234 ERQ---SAVVAAFKHSWAGYKKYAWGHDNLKPIS--------------------QYSHEWFGLGL 275

Human   106 TLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGE 170
            |::|||||:.::....||::....|.:.:..|....|::||..||||||||..:.|:      |:
  Fly   276 TIVDSLDTMYIMGLDDEFKEGRDWVEQSLRFDTKRDVNLFEVTIRVLGGLLSAYHLS------GD 334

Human   171 YMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINL-KFGIRKPEARTGTETDTCTACAGTLIL 234
            .|      .|..|.:||.:|||||.:.|.:||..:|| ......|:    ...|:.|:...|:.|
  Fly   335 TM------FLAKAAELGNRLLPAFQSPSNIPYSDVNLGDLSAHSPK----WSPDSSTSEVTTIQL 389

Human   235 EFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDS-GVGAGIDSYYEY 298
            ||..|||.|..:|:|:.|.|..:.:.: .:::..||.:.||.:||.:....: .:||..||||||
  Fly   390 EFRDLSRSTNISIYEQVAHKVNEKVHD-LEKNHGLVPIFINANTGTFRNYATISLGARGDSYYEY 453

Human   299 LLKAYVLLG---DDSFLERFNTHYDAIM-RYISQPPLLLDVHIHKPMLNARTW---MDALLAFFP 356
            |||.::..|   :|:.:..:....|.:: :.:.:.|....|:|.: ::|.:.:   ||.|..:.|
  Fly   454 LLKQWIQTGRKDNDNLILDYMQAVDGVLTQLMRRTPREHWVYIGE-LINGKDFKPKMDHLTCYLP 517

Human   357 GLQVLKGD----------IRPAIETHEMLYQVIKKH-------NFLPEAFTTDFRV--HWAQHPL 402
            |..:|...          .|..::|....|.:...|       ..|.|....|..|  :.|.:.|
  Fly   518 GTLILGHQNGMPDSHLILARDLLDTCYQTYMMNPTHLAAEISYFALTEKDDQDIYVKPNDAHNLL 582

Human   403 RPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAM---KDVRTGSHEDRMDSFFLA 464
            ||||.||.|:.|..||:..|.::|..:.:....:|:|..|:.:|   |:.::....|.|:||:::
  Fly   583 RPEFVESLYYFYSITGNRTYQDMGWKIFQAFETHAKVNAGYTSMGNVKNTQSTRLRDLMESFWMS 647

Human   465 EMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLW 499
            |..||.||||:|....| |:|.::|.:|.|.||::
  Fly   648 ETLKYFYLLFSDDRKEI-DLEQWVFNSEGHPLPVY 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EDEM3	NP_001306889.1	Glyco_hydro_47	59..498	CDD:460241	138/476 (29%)
		PA_EDEM3_like	664..789	CDD:239041
		PRK08581	<809..>936	CDD:236304
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	945..948
alpha-Man-Ib	NP_651667.1	Glyco_hydro_47	242..680	CDD:460241	138/476 (29%)