Protein Alignment EDEM3 and Edem2

DIOPT Version :10

• Sequence 1: NP_001306889.1
• Gene: EDEM3 / 80267
• HGNCID: 16787
• Length: 948
• Species: Homo sapiens
• Sequence 2: NP_609611.1
• Gene: Edem2 / 34714
• FlyBaseID: FBgn0032480
• Length: 801
• Species: Drosophila melanogaster
• Alignment Length: 756
• Identity: 381/756 - (50%)
• Similarity: 523/756 - (69%)
• Gaps: 37/756 - (4%)

Human    27 AFCLVSATSVWTAGAEP---MSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRG 88
            |.|:|.|..:.|....|   ||.:|:.:|..:..:||.|||..||::||||||||||:|:||.||
  Fly    22 AMCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRG 86

Human    89 QEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLG 153
            ..|||||:||.||.||:||:|:|||||:|....||:.||:.|:|||..|:|::|||||||||::|
  Fly    87 VTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVG 151

Human   154 GLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEART 218
            |||..|.||..|::..:.|.||..|||:|:::|||:|||||||::|:|:.|:||:.|::.|..:.
  Fly   152 GLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKDPMLKK 216

Human   219 GTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVR 283
            ..|  ||||||||::||||||||.||..|||..|..|:|.||:.|.|.|:|:|..:|:|:|||||
  Fly   217 SRE--TCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVR 279

Human   284 KDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWM 348
            :|||||||||||||||.|:|||||||.:|.|||.||:|:|:|:|:.|:||||.:|:|...::.:|
  Fly   280 RDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFM 344

Human   349 DALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFL 413
            |:||||:||||||.||::||::||||||||::.|.|:|||||.||::||.||||||||.||||||
  Fly   345 DSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQHPLRPEFIESTYFL 409

Human   414 YKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKE 478
            |:||||.:||:|||..::.|.::|:|.||:||:.|||||.||||||||.|:|..|||:|||:|.:
  Fly   410 YRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQ 474

Human   479 DIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQ 543
            |:|.::::::||||||||||.::....:......|.|:..||   |..|||::..|||      :
  Fly   475 DLIINVDEFVFTTEAHLLPLSIAQLGNATFSFRQTDEHNVLD---FMRTCPSSNRLFP------E 530

Human   544 SIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKD---G 605
            .:|:||:|.:..|||          |:.|...|.|.||.|:|.:||..:..||::::.:.|   |
  Fly   531 KVRKPLRNFITGSCP----------RTTAGKRLSALDFQASNADHLRAVYDMGITMVSVGDRSQG 585

Human   606 RVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIV----SHPFFGRVVLTAG 666
            :|:|......|.|..:.|.||:|||||:||:..|...|....:||...    |..:   :.|.||
  Fly   586 KVRLFHSFYNAKSHEEGEMGLQFMQEMLELTKMQSINQLAQLQAVAYATDENSQDW---IALMAG 647

Human   667 PAQFGLDLSKHKETRGFVASSKPSNGCSE-LTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIG 730
            |:.|..:|:..:...|.|..:||...|.| |.|.|...||:.:.:||.|.|..|||..|..||..
  Fly   648 PSHFSPELTGDQFVEGDVILAKPLRACDESLENAEEAKGKVLVAERGDCTFVSKARLAQKVGAAA 712

Human   731 GIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKE 771
            .||.|:..|||.:|.|:|.|:||||  ||:.||::|::|.|
  Fly   713 LIVCDNVPGSSGETQPMFAMSGDGK--DDVLIPVVFMYSME 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EDEM3	NP_001306889.1	Glyco_hydro_47	59..498	CDD:460241	270/438 (62%)
		PA_EDEM3_like	664..789	CDD:239041	47/109 (43%)
		PRK08581	<809..>936	CDD:236304
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	945..948
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:460241	270/438 (62%)
		PA_EDEM3_like	645..770	CDD:239041	47/109 (43%)