Protein Alignment EDEM3 and alpha-Man-Ic

DIOPT Version :10

• Sequence 1: NP_001306889.1
• Gene: EDEM3 / 80267
• HGNCID: 16787
• Length: 948
• Species: Homo sapiens
• Sequence 2: NP_733331.1
• Gene: alpha-Man-Ic / 318624
• FlyBaseID: FBgn0051202
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 146/604 - (24%)
• Similarity: 238/604 - (39%)
• Gaps: 177/604 - (29%)

Human    13 VPQRARWR-LVAATAAFCLVSATSVWTAG--------AEPMSREEKQK----------------L 52
            |.:||::. ..|.|.:...:.||.::|.|        ...|.||..||                :
  Fly     7 VIRRAQYNWYTANTKSRIRIIATGIFTVGVIVITYIQCRAMMRESFQKNIPSNDNSLKDMNPDDM 71

Human    53 GNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVL 117
            ..::.||..||:.||....:..:|..|::.|....|        |.|..|...|:|:|||||.::
  Fly    72 RAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGG--------DFATYKLGATIIESLDTLHLM 128

Human   118 NKTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQ 181
            ...||...:...:.:..:||. |..:||:|...|:|..:|..:||.      |:.:  |.|:.:.
  Fly   129 GLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLT------GDSL--YMDKAIH 185

Human   182 MAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTE--TD-TCTACAGTLILEFAALSRFT 243
            :|.    |:||||:|.:|:|...:..|      |..|.|:  :| :.|:..|:|.|||..||..:
  Fly   186 IAD----KILPAFDTPTGIPRRLVVPK------EGSTLTKYLSDISRTSEFGSLHLEFYYLSEVS 240

Human   244 GATIFEEYARKALDFLWEKRQRSSNLVGVTINIHT---GDWVRKDSGVGAGIDSYYEYLLKAYVL 305
            |..::    |:.:|.:.|...:::...|:..|.:.   |.|    ......:...|:.|||:::.
  Fly   241 GYPVY----RERVDAIREILAKTTRPNGLYPNAYCTKFGKW----ENYNCSMHRLYDTLLKSWIQ 297

Human   306 LGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIE 370
            .|      |.:|.                        ||.|:.:|:||....|.|:..:....:.
  Fly   298 SG------RTDTQ------------------------NADTFKEAMLAVAQNLVVINPEDVTYVS 332

Human   371 T-------HEMLYQVIKKHN-------FLPEAFTTDFRVHWAQHP-------------------- 401
            |       |.|      :|:       |:..|..|..: ||.::.
  Fly   333 TFRNGTLFHRM------RHSDCFAGGLFVLGAAETQMK-HWEKYAHIGIGLTDTCHDSYWSSPTR 390

Human   402 -------------------------LRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPC 441
                                     ||||.||:...|::.|..|.|...|..:::.:.||.|:|.
  Fly   391 LGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQYRLWGLEMVQAIEKYCRMPY 455

Human   442 GFAAMKDVR--TGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTN 504
            |:..:.||.  |...:|...||||....|||||||:|  |.:..:|.::|.:..|.||:
  Fly   456 GYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSD--DDVVSLEQWVFNSAGHFLPI------ 512

Human   505 QSISKKNTTSEYTELDDSN 523
                 |.....|.:.:.||
  Fly   513 -----KGVNPMYRQHNSSN 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EDEM3	NP_001306889.1	Glyco_hydro_47	59..498	CDD:460241	126/506 (25%)
		PA_EDEM3_like	664..789	CDD:239041
		PRK08581	<809..>936	CDD:236304
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	945..948
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:460241	126/506 (25%)