DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EDEM3 and Edem1

DIOPT Version :10

Sequence 1:NP_001306889.1 Gene:EDEM3 / 80267 HGNCID:16787 Length:948 Species:Homo sapiens
Sequence 2:NP_001259152.1 Gene:Edem1 / 31154 FlyBaseID:FBgn0023511 Length:1004 Species:Drosophila melanogaster


Alignment Length:985 Identity:287/985 - (29%)
Similarity:436/985 - (44%) Gaps:227/985 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    30 LVSATSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRG 94
            |:...|...:|.:..|:..|.:|...|..||.|||..|:.||...|||.||||.|.         
  Fly    19 LLVLLSTGVSGQKQYSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPLTCDGH--------- 74

Human    95 DVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGH 159
               |..|.:||||||:||||..:....||..|.|.:...::.|.|:.|||||||||::||||..|
  Fly    75 ---DTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGGLLSAH 136

Human   160 SLAIMLKEKGEYMQ--W-YNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTE 221
            .|:   |..|..::  | ....||::|:.:..:|||||.|.:|:||..:||::|:.|     |..
  Fly   137 LLS---KRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRYGVPK-----GET 193

Human   222 TDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDS 286
            :.||||..||.::||..|||.||.||:|:.|.||:..||..|. ...|.|..|::.:|.|...||
  Fly   194 SITCTAGVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRS-PIGLFGNHIDVQSGRWTALDS 257

Human   287 GVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDAL 351
            |:|||:||.:|||:||.|||.....||.|:....||.:|:.:....:.|.::|..:....: .:|
  Fly   258 GIGAGVDSLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVF-QSL 321

Human   352 LAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTT---DFRVHWAQHPLRPEFAESTYFL 413
            .||:||:..:.||..||:.|......|.||:.||||.:..   :...:...:|||||..||..:|
  Fly   322 EAFWPGILSIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYL 386

Human   414 YKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKE 478
            |:|||:.|.||.|:.::|.|...|:..||:|.:::|.|...|:||:||||||..||||||| |:|
  Fly   387 YRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLF-DEE 450

Human   479 DI---------IFDIED---------YIFTTEAHLLPLWLSTT------NQSI------------ 507
            :.         :...||         |||.||||  |:.:|..      |:.|            
  Fly   451 NFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAH--PMDMSALHCCHAHNEDIYTSLDLQRFSPR 513

Human   508 -----SKK---------------------NTTSEYTELDDSN--------------------FD- 525
                 |||                     |...|..:..||.                    || 
  Fly   514 AILERSKKRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQEREQSGTSTTMAVDIEVFDE 578

Human   526 WTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIR--------VEESFRSGAKPPLRARDFM 582
            :..|...:|..|    .:.|||  :..:::|..|.::.        ::|.|       .:.|:..
  Fly   579 FQQPAGDLLVSN----FEQIRE--ERELNESLHRNVVARNQLTVSDLDEFF-------AQRRESF 630

Human   583 ATNPEHLEILK------KMGVSLI---HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQ 638
            |:..|.|..:|      .|.|:.|   .|.|..:..|   :...:..:.|..:|.:.::.||  |
  Fly   631 ASASEALNYVKTFMGNYTMDVAFIRGLQLYDTNMSSV---LGTGAQKEYESRMRTLWQLYEL--Q 690

Human   639 QQKEQQLPPRAVQ---IVSHPFFG-RVVLTAGPAQFGLDLSKH--------KETRGFVASSKPSN 691
            ||....:  |.:|   :::.|..| |:..........||.|.|        .|||          
  Fly   691 QQYVANI--RVIQGLGLLTFPADGDRIPSHLTEVLDSLDKSAHLEHMDLQDLETR---------- 743

Human   692 GCSELTNPE-AVMGKIALIQRGQCMFAEKARN-----IQNAGAIGGIVIDDNEGSSSDTA----P 746
             .|..::|: |.:.::.|          ||||     :.|..|:....|......:|:..    |
  Fly   744 -VSNTSSPQLAHIREVIL----------KARNAYAIAMVNTSAMQEFAIRIYLSGTSEAGVRIHP 797

Human   747 LFQMAGDGKDTDDI-KIPM-------LFLFSKEGSIILDAIREYEEVEVLLSDKAKDRAAILKGK 803
            |.:   ||:.:::. |.|:       ||.:::.   |:|..:...|        ..||...|...
  Fly   798 LLE---DGELSEEARKRPLKLAEERALFSYARR---IVDFRKRMAE--------TVDRLQTLMQD 848

Human   804 MIPSYIINSNPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADM 868
            :.|.    ...|...:.|.:..:....|:..|:::.:|:     .|.|:|...::..:...||  
  Fly   849 IPPP----KRKEATTDSQAADASTVYTQTKAQMAAPAQQ-----PEPSQEEKQSTQIQKGKLA-- 902

Human   869 DNAASISPSE 878
            :|.:.:...|
  Fly   903 ENGSGLGEEE 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EDEM3NP_001306889.1 Glyco_hydro_47 59..498 CDD:460241 188/462 (41%)
PA_EDEM3_like 664..789 CDD:239041 30/150 (20%)
PRK08581 <809..>936 CDD:236304 12/70 (17%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 945..948
Edem1NP_001259152.1 Glyco_hydro_47 48..486 CDD:460241 188/462 (41%)
Blue background indicates that the domain is not in the aligned region.

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