Protein Alignment EFHC2 and Efhc1.2

DIOPT Version :10

• Sequence 1: NP_079460.2
• Gene: EFHC2 / 80258
• HGNCID: 26233
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_611459.1
• Gene: Efhc1.2 / 37284
• FlyBaseID: FBgn0034487
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 791
• Identity: 272/791 - (34%)
• Similarity: 421/791 - (53%)
• Gaps: 82/791 - (10%)

Human     3 LPLLPGNSFNRNVGKEKFHKSQHWGFCNNVMMLVSDEKPGIGGEPLL----GQKIKPKC------ 57
            :|:|||..| .:.||.:..:.|.......:.|| ||.:     ||.|    |....|||
  Fly     7 MPMLPGAQF-YDRGKRRHPRQQTLMHYQGIQML-SDRR-----EPELVEPNGIVADPKCPPVPAQ 64

Human    58 --SIYPKGDGSDVPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRYYKIYFYPEDDTIQVNEPEV 120
              |::.....:.:|.|:|:|||||.|:||.:|.:.:.....|::|..||:||.||.|:||.||:|
  Fly    65 LNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLEDGTMQVTEPKV 129

Human   121 KNSGLLQGTSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFYGRTFKIYDCDAFTRNFLRKIGVKV 185
            :|||:.||..:.|.||...||.:.:|.:::..||.|:|..:.|.:.|..||.|||.||.:.|:.|
  Fly   130 ENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFTRQFLNRAGIFV 194

Human   186 NPPVQCPEDPYMKIRREVVEHVEPLRPYESLDT--------LKQFLQYHGKILCFFCLWDDSVSM 242
            ....|.|.||..:||:.     ..|:...:..|        ..|||::..::|.|...|:|. |.
  Fly   195 PEAQQEPCDPTTEIRKR-----SGLKQTGNTATSALPKKHAFAQFLEFDRRVLKFQGYWNDR-SE 253

Human   243 FGDRRELILHYFLCDDTIEIKELLPHSSGRDALKMFLRRSKLPK---NCPPRVYQPGQITDRAVL 304
            |||.|:|.:.|:|.||||:|||..|.:|||:....||:|.||||   ..|    .|||.|...:|
  Fly   254 FGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLP----LPGQQTAMTLL 314

Human   305 NSYGDFIKNQADGYLFDRYKLGKVDQEFYKDSDLSLGVTINVWGRKVLLYDCDEFTKSYYKSKYG 369
            |..|:.:::..  |:.|....|:.:.:.|.|.||.:|..:||:||.|:|..||:||:|||:.|||
  Fly   315 NVLGNSMRDVR--YVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKYG 377

Human   370 IENFTSVSCKPPSPPPKI------------ERKFPPYNGFGSEEDSLRNCIDLKPTPHRRNFKKF 422
            |:.|:      |.|.|:.            .|:.|||||:||.|||..|||.::|.|.:.:|||.
  Fly   378 IQEFS------PQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKL 436

Human   423 MEKDSYGSKSNILRFFAKLVTDKCVDLDRMFVISYYLGDDTISVFEPIERNSGIAGGMFLKRSRV 487
            .:.|..     ||||.|||::....:.:|.|||||:|.|||:.::|...||||..||.||||:||
  Fly   437 FKYDGC-----ILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARV 496

Human   488 KKPGQEVFKSELSEYIKAEELYIGVTVNVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQK 552
            ..|||:::.|...||.:|.:.|||.|:.:..::|.:::|||:||.||||:..::|.::::..:||
  Fly   497 PLPGQDMYSSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQK 561

Human   553 LKQEEGKSRELKQ-VFKA---ADSKHTNMVDYNTFRDILMS-LTVGNLAEQEFVTIARHYRVPEG 612
            ::  |....:.|| |.:.   .|......|.:.|.|..|:| |:...|...|.||:.|.:...:.
  Fly   562 IR--EAVRPDYKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSAEQA 624

Human   613 ---TCSDMDFLIALAHEKFKKNMFENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDL 674
               :| |.:.:.|.|..:.|:.::...|.......:.:...|..:....::...:..|||.|.:|
  Fly   625 MPPSC-DRNRVRAAAQLELKRALWNGMDQLNDHLSHINPACKPYISEGQVRSTLRGCRLPFSLEL 688

Human   675 LESLLSRFE-DSEKQIDYKSFFSALNWRKNPVPELQPASYLKERCEDVWLGMPSPIPAKYIDYWT 738
            :|.:|...: :.:.:|:.:.|.:..|.|.:.||::.|.:...|.|..    :|.....:.:|:..
  Fly   689 VEDILMVLQRNGQNEIEVRDFLAFFNMRNDQVPDIAPLNIAFELCPK----LPFLHKGRLVDFTW 749

Human   739 FLKDAFGLEEE 749
            || |..|:|||
  Fly   750 FL-DYLGIEEE 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EFHC2	NP_079460.2	DM10	75..182	CDD:128921	47/106 (44%)
		DM10	226..368	CDD:128921	59/144 (41%)
		DM10_dom	419..530	CDD:461948	49/110 (45%)
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	47/106 (44%)
		DM10_dom	231..368	CDD:461948	57/143 (40%)
		DM10	440..547	CDD:128921	52/111 (47%)