Protein Alignment EFHC2 and Efhc1.1

DIOPT Version :10

• Sequence 1: NP_079460.2
• Gene: EFHC2 / 80258
• HGNCID: 26233
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_573075.1
• Gene: Efhc1.1 / 32528
• FlyBaseID: FBgn0030691
• Length: 793
• Species: Drosophila melanogaster
• Alignment Length: 763
• Identity: 252/763 - (33%)
• Similarity: 409/763 - (53%)
• Gaps: 46/763 - (6%)

Human     3 LPLLPGNSFNRNVGKEKFHKSQHWGFCNNVMMLVSDEKPG--IGGEPLLGQKIKP--KCSIYPKG 63
            :|||||..| |:|.|..:.|.|.......:.||...::|.  ..|...:.....|  ..||||..
  Fly     7 MPLLPGTLF-RDVSKGHYPKPQSLANVQGLSMLSDRQQPAPVESGSVTVDISCPPVGASSIYPPR 70

Human    64 DGSDVPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRYYKIYFYPEDDTIQVNEPEVKNSGLLQG 128
            .|..:|.|:|:||:||.|.||.::.:.:.....|.:|..|||:|.||.|:::.||.|.|||::||
  Fly    71 SGPRMPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQG 135

Human   129 TSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFYGRTFKIYDCDAFTRNFLRKIGVKVNPPVQCPE 193
            ..:.|.|:...||.:::|.::...||...|..:.|.:.|.|||.|||.||.|.|:.|..||:.|.
  Fly   136 CVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRTFLNKRGITVPDPVKSPC 200

Human   194 DPYMKIR-REVVEHVEPLRPYESLDTLKQFLQYHGKILCFFCLWDDSVSMFGDRRELILHYFLCD 257
            ||..:.| ||.......|.|..  ....|||:|..:||.|...|||... |||.|:|.|.|:|.|
  Fly   201 DPTEEQRKRENQPRSGNLIPKN--HPFAQFLKYDRQILKFQAYWDDRTE-FGDVRKLELCYYLSD 262

Human   258 DTIEIKELLPHSSGRDALKMFLRRSKLPKNCPPRVYQPGQITDRAVLNSYGDFIKNQADGYLFDR 322
            |||||||....:||||...:||:|.:|.:.. ..:..|||:|...:||..|..::|..  |..|.
  Fly   263 DTIEIKEQHIRNSGRDGPTVFLKRGRLAREF-EGLQLPGQMTPMTLLNVLGTNMRNVR--YCVDP 324

Human   323 YKLGKVDQEFYKDSDLSLGVTINVWGRKVLLYDCDEFTKSYYKSKYGIENFTSVSCKPPSPPP-- 385
            ...|..:..:|::.||.:|..|||:||.|::.:.|.||::||:.:|||::||      |.|.|
  Fly   325 LNTGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDFT------PLPIPAR 383

Human   386 -------KIERKFPPYNGFGSEEDSLRNCIDLKPTPHRRNFKKFMEKDSYGSKSNILRFFAKLVT 443
                   :.||:.|||||:||.|||:.|||.::|.|.:.:||||::.|.|     :|||.||:::
  Fly   384 SDDCADHRSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDRY-----VLRFGAKMLS 443

Human   444 DKCVDLDRMFVISYYLGDDTISVFEPIERNSGIAGGMFLKRSRVKKPGQEVFKSELSEYIKAEEL 508
            ....:.:|:|||||||.|||:.:.|...||||..||.|:||:|::.||||.|..:..:|......
  Fly   444 TIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFSCKQPQYYMPWNF 508

Human   509 YIGVTVNVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQKLKQEEGKSRELKQVFKAA--- 570
            ::|.|:::..::|.:::||||||.|||.:.:.:|.:|:.:.::|:|... ::|..:.|....
  Fly   509 FVGSTMSLKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSAL-QNRMAEFVGSCVPDC 572

Human   571 ---DSKHTNMVDYNTFRDILMSLTVGNLAEQEFVTIARHYRVPEG--TCSDMDFLIALAHEKFKK 630
               :.|....|.:.:|:..|:|:....:::.|.:::.||:...:.  ...|...:.|.||.:.|:
  Fly   573 TDLEKKRDVFVSFESFKGALISIMGNQISDHEIISLCRHFSAEKSQPNACDRSTVRAAAHLELKR 637

Human   631 NMFENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDLLESLLSRFEDSE-KQIDYKSF 694
            .::...|..:....:.:...:..||...::...:..|||.|.:|::::||....:| ..|:....
  Fly   638 TLWNARDDLMEHFHHINPTNQPFLPEVKVRSALRGCRLPFSLELIDNILSILNRNECDDIEVCDL 702

Human   695 FSALNWRKNPVPELQPASYLKERCEDVWLGMPSPIPAKYIDYWTFLKD 742
            .:.::.......::.|.::..|.|..:    |.....:.:::..||::
  Fly   703 MNFIDVSCGKGCDMLPVNHAFELCPKI----PFLNKGRVVNFTCFLRE 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EFHC2	NP_079460.2	DM10	75..182	CDD:128921	43/106 (41%)
		DM10	226..368	CDD:128921	56/141 (40%)
		DM10_dom	419..530	CDD:461948	45/110 (41%)
Efhc1.1	NP_573075.1	DM10	82..189	CDD:128921	43/106 (41%)
		DM10	232..370	CDD:128921	56/141 (40%)
		DM10_dom	424..530	CDD:461948	45/110 (41%)