Protein Alignment RUFY1 and Rufy1

DIOPT Version :10

• Sequence 1: NP_079434.3
• Gene: RUFY1 / 80230
• HGNCID: 19760
• Length: 708
• Species: Homo sapiens
• Sequence 2: NP_001094197.1
• Gene: Rufy1 / 360521
• RGDID: 1305099
• Length: 711
• Species: Rattus norvegicus
• Alignment Length: 713
• Identity: 655/713 - (91%)
• Similarity: 673/713 - (94%)
• Gaps: 7/713 - (0%)

Human     1 MADREGGC-AAGRGRELEPELEP--GPGPG--SALEPGEEFEIVDRSQLPGPGDLRSATRPRAAE 60
            ||.| |.| .||:..|.||:.||  .|.||  :.||.|||||||||||||.||:||||:|.||||
  Rat     1 MAAR-GDCRRAGQDSEPEPKPEPESRPEPGLQAGLESGEEFEIVDRSQLPSPGELRSASRTRAAE 64

Human    61 GWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMMKLSIK 125
            .|||||||||||||||||||||||||||||||.|..|.| .|||||.||||||||||||||||||
  Rat    65 SWSAPILTLARRATGNLSASCGSALRAAAGLGDGGGGGG-ERAASKGQMMEERANLMHMMKLSIK 128

Human   126 VLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDI 190
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   129 VLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDI 193

Human   191 ATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGL 255
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   194 ATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGL 258

Human   256 LVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSC 320
            ||||||||||||||||||||||||||||||||||||||.|:||||||||||||||||||||||||
  Rat   259 LVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDSGREHERITDVLDQKNYVEELNRHLSC 323

Human   321 TVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVE 385
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   324 TVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVE 388

Human   386 LETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLV 450
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   389 LETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLV 453

Human   451 ALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGA 515
            |||||||||||||||||||.|:||||||||:|||.||||||.||||||||||||||.:|||||||
  Rat   454 ALRQQLEEVKAINLQMFHKVQSAESSLQQKDEAIASFEGKTTQVMSSMKQMEERLQQAERARQGA 518

Human   516 EERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQ 580
            ||||:||||||.||:.|||||||||.:|||.|||||||||||||.||||||||||||.||:.|||
  Rat   519 EERSYKLQQELSGRVSALQLQLSQLRDQCSGLEKELKSEKEQRQTLQRELQHEKDTSCLLQTELQ 583

Human   581 QVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEA 645
            |||||||||||||||||||:|:|||||||||||||||||||||||||||||:|||||.|||||||
  Rat   584 QVEGLKKELRELQDEKAELRKVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKGHTWLKDDEA 648

Human   646 THCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 708
            |||:||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   649 THCKQCEKDFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUFY1	NP_079434.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		37/60 (62%)
		RUN_RUFY1	112..267	CDD:439056	154/154 (100%)
		SMC_prok_B	<373..>629	CDD:274008	235/255 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..522		25/28 (89%)
		Interaction with RAB4. /evidence=ECO:0000269|PubMed:20534812	615..625		9/9 (100%)
		FYVE_RUFY1	634..704	CDD:277297	66/69 (96%)
Rufy1	NP_001094197.1	RUN_RUFY1	115..270	CDD:439056	154/154 (100%)
		SMC_prok_B	<376..>632	CDD:274008	235/255 (92%)
		FYVE_RUFY1	637..707	CDD:277297	66/69 (96%)