Protein Alignment RUFY1 and rabn-5

DIOPT Version :10

• Sequence 1: NP_079434.3
• Gene: RUFY1 / 80230
• HGNCID: 19760
• Length: 708
• Species: Homo sapiens
• Sequence 2: NP_498266.1
• Gene: rabn-5 / 175823
• WormBaseID: WBGene00017161
• Length: 414
• Species: Caenorhabditis elegans
• Alignment Length: 412
• Identity: 92/412 - (22%)
• Similarity: 190/412 - (46%)
• Gaps: 99/412 - (24%)

Human   303 DVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQ---EELSAATDRICSLQEEQQQLREQN 364
            |:.::::|.:||.:.::....:...:::...|.|:|.:   :||||..|:  |::....||....
 Worm    74 DLSNERDYRKELEKKMNELSTNCLNQVNEAAKANAKSEQRLDELSAKHDK--SIEVFTDQLNLAR 136

Human   365 ELIRERSEKSVEITKQDTKVELETYKQ----TRQGLDEMYSDVWKQLKEEKKVRLELEKEL-ELQ 424
            :.:::..:..|.:.|:        ||:    ||:...|:.|:           ::::..:| :||
 Worm   137 DKLQQADDDFVTLGKK--------YKKLLGSTRKSAQELRSE-----------KIDMPADLDQLQ 182

Human   425 -IGMKTEMEIAMKLLEKDTHEK--QDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITS 486
             |.:|...|:......|:..|:  ||.:..||.|:.|.:|                .::::.:|
 Worm   183 FICLKNREELIETRAAKEHTEQQLQDEITVLRAQILEERA----------------HREDQEVT- 230

Human   487 FEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQ-QELGGRIGALQLQLSQLHEQCSSLEKE 550
            |..:.:::.|.:.::..|:..:....  |::.|:..| ::|...:|.|:.|:.|:..:.:::|:.
 Worm   231 FTAEISRLQSELGKINTRMVVASETI--ADQDSNIRQIRDLQTTVGELETQVQQVQNERAAVEQT 293

Human   551 LKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGL 615
            .::.|::..:||:||    |||.:::.:.                                   :
 Worm   294 AQNYKQRCTSLQQEL----DTSEVVQRDF-----------------------------------V 319

Human   616 HLSQS-KLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNE 679
            .|||| ::::|.|::..|.::   |..||:...|..|:..|:..:.|.||.:||.|||..|..:
 Worm   320 KLSQSLQIQLEKIRQSEQEVR---WQWDDDVDQCSNCDTSFARVKVKPHCLHCGRIFCMNCLKD- 380

Human   680 LALPSYP--KPVRVCDSCHTLL 699
             .:||.|  :|..||..|||||
 Worm   381 -TVPSGPNHRPANVCKVCHTLL 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUFY1	NP_079434.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57
		RUN_RUFY1	112..267	CDD:439056
		SMC_prok_B	<373..>629	CDD:274008	50/265 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..522		4/28 (14%)
		Interaction with RAB4. /evidence=ECO:0000269|PubMed:20534812	615..625		4/10 (40%)
		FYVE_RUFY1	634..704	CDD:277297	26/68 (38%)
rabn-5	NP_498266.1	Rab5-bind	37..336	CDD:462752	65/340 (19%)
		FYVE_RABE_unchar	338..410	CDD:277278	26/69 (38%)