Protein Alignment RUFY1 and rufy1

DIOPT Version :10

• Sequence 1: NP_079434.3
• Gene: RUFY1 / 80230
• HGNCID: 19760
• Length: 708
• Species: Homo sapiens
• Sequence 2: XP_002667361.2
• Gene: rufy1 / 100330077
• ZFINID: ZDB-GENE-090421-4
• Length: 697
• Species: Danio rerio
• Alignment Length: 718
• Identity: 445/718 - (61%)
• Similarity: 562/718 - (78%)
• Gaps: 31/718 - (4%)

Human     1 MADREGGCAAGRG----RELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAEG 61
            |||.:.......|    :|.|||:         .|.|:| ::.:.:      |.....|| |...
Zfish     1 MADEDPNTKVESGDVPAKEEEPEV---------TETGQE-DVANNT------DELQKDRP-ADSS 48

Human    62 WSAPILTLARRATGNLSASCGSALRAAAGLGGGD-----SGDGTARAASKCQMMEERANLMHMMK 121
            ||||||:.||:||..||:...   ..:|||...|     |.|....||.|..::.||:||:.|||
Zfish    49 WSAPILSFARKATETLSSGVN---HYSAGLKTPDTTQQHSSDPVKIAAVKDPVVVERSNLLSMMK 110

Human   122 LSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG-QNKSFFGPLELVEKLCP 185
            ||||||:||:|||||:||:::.||||||||:||||||||||:||||| ||||.:.|||::|||||
Zfish   111 LSIKVLIQSSLSLGRTLDSEYPPLQQFFVVLEHCLKHGLKVRKSFIGLQNKSIWAPLEMIEKLCP 175

Human   186 EASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGM 250
            |::|||||||::|.:||.:||.||||:|||||||:|||:||||:.:.||.|||||.||:|||||.
Zfish   176 ESADIATSVRDMPGIKTGLGRARAWLHLALMQKKIADYMKVLINRRDLLGEFYEPGALVMEEEGA 240

Human   251 VIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELN 315
            ||||:||||||:|||||:|||||||||.|||||:||||.|..:..::..::|.:||||:|:||||
Zfish   241 VIVGMLVGLNVIDANLCVKGEDLDSQVCVIDFSMYLKDPQATESKQDDSKMTAILDQKHYIEELN 305

Human   316 RHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQ 380
            |||||||.|||.|:|.||||||||.|||:||||||.:|:|||:||:::|..|.:.|::..|:|.|
Zfish   306 RHLSCTVTDLQAKMDSLEKTNSKLIEELTAATDRINALREEQEQLKQENANILQSSQRKEEVTLQ 370

Human   381 DTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEK 445
            |::||||||:|||||||||||.||||.||||::|.||:||||||||:|.|||:||||||||||||
Zfish   371 DSQVELETYRQTRQGLDEMYSVVWKQYKEEKRIRQELQKELELQIGLKQEMEVAMKLLEKDTHEK 435

Human   446 QDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSER 510
            |||||||||||::||.:|||||:|||.::...|:|.|.:...|.|..|:.::||::|:|||:||.
Zfish   436 QDTLVALRQQLDQVKNLNLQMFNKAQASDRVAQKKEEDMVHLEKKMIQMEAAMKELEQRLQNSED 500

Human   511 ARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLL 575
            .::..:|:.::::.|:.|::.|||.:||.|....:.||.||.:||||||.||:|||.|:|.|:.|
Zfish   501 VQKNTDEQQNEIRTEMKGKVNALQKRLSDLDTLRAGLETELSAEKEQRQILQKELQREQDNSAEL 565

Human   576 RMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWL 640
            |.:|||::||:.||.:|:.||.:||::||||||||||||||||||||||||.||||:||||||||
Zfish   566 RTQLQQLQGLQTELLDLRQEKQQLQQLCEEQEQALQEMGLHLSQSKLKMEDFKEVNKALKGHAWL 630

Human   641 KDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSS 705
            ||||||.|:||:||||||||||||||||.|:|..|||||||||||||||||||.||:||||| ||
Zfish   631 KDDEATQCKQCQKEFSISRRKHHCRNCGDIYCGNCSSNELALPSYPKPVRVCDVCHSLLLQR-SS 694

Human   706 TAS 708
            |.|
Zfish   695 TGS 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUFY1	NP_079434.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		13/59 (22%)
		RUN_RUFY1	112..267	CDD:439056	115/155 (74%)
		SMC_prok_B	<373..>629	CDD:274008	156/255 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..522		10/28 (36%)
		Interaction with RAB4. /evidence=ECO:0000269|PubMed:20534812	615..625		9/9 (100%)
		FYVE_RUFY1	634..704	CDD:277297	60/69 (87%)
rufy1	XP_002667361.2	RUN	101..257	CDD:459241	115/155 (74%)
		Smc	<317..>559	CDD:440809	143/241 (59%)
		FYVE_RUFY1	624..694	CDD:277297	60/70 (86%)