Protein Alignment ORAI2 and Orai

DIOPT Version :10

• Sequence 1: NP_116220.1
• Gene: ORAI2 / 80228
• HGNCID: 21667
• Length: 254
• Species: Homo sapiens
• Sequence 2: NP_001137696.1
• Gene: Orai / 37040
• FlyBaseID: FBgn0041585
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 265
• Identity: 128/265 - (48%)
• Similarity: 162/265 - (61%)
• Gaps: 37/265 - (13%)

Human     2 SAELNVPIDPSAP----------ACPEP-----GHKGMDYRDWVRRSYLELVTS------NHHSV 45
            :|....||.|.||          |.|.|     ..:...||...|..:....:|      :.||.
  Fly   235 AASAVAPIAPLAPLASIASPPFAAQPPPFQLRTYQQNQSYRFQPRGHHRTASSSMSQSGEDLHSP 299

Human    46 QALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLF 110
            ..||||||.||||||||||:||||||||||||||||||:.....|..:||||:.|||:|||||:.
  Fly   300 TYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHML 364

Human   111 ALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLP 175
            ||:||||||||:|.|.|:|:::.:.||||||:|.|||.||.|||:||::|||.|:.:|||:||..
  Fly   365 ALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYD 429

Human   176 VDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKL 240
            :.       ||     ..|.|.    ::::||.:||:.|.||||||||.||.|.....|.||..|
  Fly   430 LS-------PP-----AAWSAC----VVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEML 478

Human   241 KVQLD 245
            |.|::
  Fly   479 KEQME 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI2	NP_116220.1	Orai-1	47..228	CDD:462291	106/180 (59%)
Orai	NP_001137696.1	Orai-1	301..466	CDD:462291	106/180 (59%)