Protein Alignment ORAI2 and orai-1

DIOPT Version :10

• Sequence 1: NP_116220.1
• Gene: ORAI2 / 80228
• HGNCID: 21667
• Length: 254
• Species: Homo sapiens
• Sequence 2: NP_001254835.1
• Gene: orai-1 / 175221
• WormBaseID: WBGene00015648
• Length: 297
• Species: Caenorhabditis elegans
• Alignment Length: 215
• Identity: 84/215 - (39%)
• Similarity: 126/215 - (58%)
• Gaps: 39/215 - (18%)

Human    39 TSNHHSVQA---------------LSWRKLY-LSRAKLKASSRTSALLSGFAMVAMVEVQLETQY 87
            |:.||::..               ||.:..| ||||:|||||||||||:|||||.:||:|.:  .
 Worm    83 TATHHTLSPVIQCFQQDQHRGELDLSEKYNYDLSRAQLKASSRTSALLAGFAMVCLVELQYD--Q 145

Human    88 QYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGF 152
            ..|:||||.....|::||:|||.||::||||||.:||.      ....:|||.::..||:|:|.|
 Worm   146 STPKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEAT------GCTQDSPHIKLKFYIDLSWLF 204

Human   153 STVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIH 217
            ||.:|:||||.|:.::.::||..|      |.|         .|..::|.::||||::||||:..
 Worm   205 STCIGLLLFLVEIGVIFYVKFTAV------GYP---------TAGYITTAMLVPVGVVFVVFSYL 254

Human   218 FYRSLVRHKTERHNREIEEL 237
            .:::.|.|...|...:::.:
 Worm   255 IHKNRVSHSLGRFKHKVDTM 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI2	NP_116220.1	Orai-1	47..228	CDD:462291	80/196 (41%)
orai-1	NP_001254835.1	Orai-1	108..263	CDD:462291	78/177 (44%)