DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAB11FIP1 and TCB3

DIOPT Version :9

Sequence 1:	NP_001002814.2	Gene:	RAB11FIP1 / 80223	HGNCID:	30265	Length:	1283	Species:	Homo sapiens
Sequence 2:	NP_013639.1	Gene:	TCB3 / 854903	SGDID:	S000004537	Length:	1545	Species:	Saccharomyces cerevisiae

Alignment Length:	1265	Identity:	243/1265 - (19%)
Similarity:	434/1265 - (34%)	Gaps:	345/1265 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   132 PGKKDKERGEIEVDI---QFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTAS--- 190
            ||.|...:..|..:|   .|..|::..::.|: |..:|:...|.|...|...:...|||..:
Yeast   450 PGLKSFVKNIINSNIGPMLFPPNHLDINVEDI-MAAQSKEAIGVLAVTIASADSLKGSDFITNTV 513

Human   191 --AIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDF 253
              .|:.:|..:|...||          :::|.: |||::....:::..:|..:..:|:.|:..||
Yeast   514 DPYIVMTTEDAVPGTDE----------EVRTSI-KSNVKNPRWNETKYLLLNTLEQKLNLKCFDF 567

Human   254 QSQWDEDDNEDESSSASDVMSH----KRTAS--TDLKQLNQVNFTL---PKKEGLSFLGGLRSKN 309
            .....:....|.....:|::.:    .:||.  :..|....::::|   |.||.       :|:.
Yeast   568 NDVRKDTVIGDLQLDLADLLQNPVLDNQTAELRSGTKSKGILHYSLHWFPVKED-------KSEE 625

Human   310 DVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRK----KHLFSSTENLAAGSWKEPA 370
            ..:.|:.....|.... |..:...:.:|.:..||.:..|..|    |..:..|.:...||....|
Yeast   626 KAVERAEAKAKGKKED-ENEDTTEKEEDENEESSQTDVGIAKITLQKVKYLDTTSSMTGSLSPCA 689

Human   371 EGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSS 435
            |   |..|.|             .:.|||       .||....|:.:|..:....||   |....
Yeast   690 E---LFIDGQ-------------KVKSYR-------TLRRINEPSWNETIEVLVPSK---SNSKF 728

Human   436 LLSL----MTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRS-EKDTAAVV 495
            :|.:    |.||..:.:.|...:.:..                 ....|::.|:.| :.|....|
Yeast   729 VLKIFDDRMNGKALICEYSSSLDDIMT-----------------TLDTAQEFVKGSPQGDIYLDV 776

Human   496 SRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDS 560
            |        ::.:::|...|...|.|||...|             :|:|.     .|.:......
Yeast   777 S--------WKSIEMTGAFAAANSVSEPIGCI-------------KLDVK-----DAIIKGDLSG 815

Human   561 PSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKS 625
            ...:.|..:.|....|..:..:.:||   :.|...:|...||.:|....| :|.......|:.:.
Yeast   816 VGDVDPYYTVSLNRRVLYKSIYHSDT---DHPIFDNSTYVPIFSPNQILT-LEFHDYQKIGKDRF 876

Human   626 EGPPLLPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTED--SLMGRTRETGTEKNTSSL- 687
            .|...:|.:.:..:.    |.||           .:..|.|.|:  .|..:..|   .|.|.|:
Yeast   877 IGSVQIPTSNVFKKD----PKSG-----------KYVGNNGKEEISKLKLKDHE---HKVTESIV 923

Human   688 ----------------------ELEESLPEQP---ETGRQEEELPRFPCKKQDYSPSSGEAQEV- 726
                                  :||:.|.|:.   |..::|.|      ::.:.:|...|..|:
Yeast   924 NVSTTFIPINLVYSPEELVNVEKLEKELKEKKKKFEATQEENE------QEMEKNPKEWEVAEIE 982

Human   727 -PFALSLSSDGAVSPVGELA-------AGGDRDLESQAGSLVESKA--RDAAEEVAPP--LPMGA 779
             ||.   |.:..::...:|:       ..|...::...|:|..|.|  ...|::::.|  :.|..
Yeast   983 DPFD---SDEKKINRKAKLSLNELIKQKSGILSMQILEGTLSPSSAYLEILADDISYPVFICMKP 1044

Human   780 SVPSIDSMMRKLEEMGLNLRKDQKKTKKR--VSFSEQLFTEEAVAGAALLVEGHSSCPQELNPAW 842
            |...::|.|..:....||..|...:..|:  ...|:.:.:|.:.:...||.:.:.      .|.|
Yeast  1045 SQGKLNSEMANIFIRDLNYSKLHFRVSKKHIAKDSDDVISETSYSTLKLLKQAYE------EPMW 1103

Human   843 SVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKD 907
             :..|.|           ..:...:.||            ..:.|||.|            |.:|
Yeast  1104 -LNFNGS-----------KMKVRFLYTP------------TSVKLPSSE------------SVED 1132

Human   908 TPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSD---FKSPIMADLNLSLPSIPEVASDD 969
            |....::    |::.:..|::|..| .|||...: .|:|   |||      |:...::..|.::|
Yeast  1133 TGYLNIK----LISGHGLKSADRNG-YSDPFVHI-FVNDKKVFKS------NIKKKTLDPVWNED 1185

Human   970 ERIDQVEDDGDQV---------EDDGETAKSSTLDIGALSLG----------------------- 1002
            .:|..:....:||         ..|.:....::||:.:|.:|
Yeast  1186 AKIPILSRSKNQVIFNVLDWDRAGDNDDLGQASLDVSSLEVGKTYNWNLNLNTQGSIKLQGSFNP 1250

Human  1003 -LVVPCPERGKGPSGEADR-LVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHK-PHLGKS----- 1059
             .:.|..:..||  |..|: :.:..|.....:......:.|.:...|. |:.| .||.||
Yeast  1251 EYIKPSFDIVKG--GITDKPMKIASGAAHATVGIAGTGIGAATGVATG-GLKKGGHLLKSLGGNP 1312

Human  1060 -----SSLDKQLPGPSGGEEEKPMGNGSP------SPPPGTSLDNPVPSPSPSEIFPVTHSFPSS 1113
                 ||...:..|.....|:|.....||      |..|..|||.. ||...:...||..:.|
Yeast  1313 MKRSKSSNGNESNGAKKSSEKKSFDRRSPSNLNSTSVTPRASLDYD-PSVPNTSYAPVQSASP-- 1374

Human  1114 AHSDTHHTSTAESQKKATAEGSAG--RVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKH-- 1174
            ....|.:||::.::|...:..|.|  |..:|.:.       ::|..|:.......|....|||
Yeast  1375 VVKPTDNTSSSSNKKDTPSSNSRGHSRASSFART-------LAPHGTYNGFITVVAAENVAKHVQ 1432

Human  1175 ------------RLHPVKPMNA--------------MATKVANCSLGTATIISENLNNEVMMKKY 1213
                        .::..|...|              .|:..||..||..:....:.:.::.:.:.
Yeast  1433 IKISLTQGGRLKHIYKTKSQKANNDGVAVFDEECSFKASPEANLVLGAISHQRLSRDKDLGIAQI 1497

Human  1214 SPSDPAFAYAQLTHDELIQLVLKQKETISK 1243
            :..||     |:..|..|.:.|.....|.|
Yeast  1498 NLGDP-----QIQQDGQISVKLGDGHLIVK 1522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB11FIP1	NP_001002814.2	C2_Rab11-FIP_classI	20..147	CDD:176064	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..281		26/130 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..727		81/435 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..782		10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..913		13/77 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..993		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1141		32/122 (26%)
		Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling	1219..1283		6/25 (24%)
		RBD-FIP	1226..1273	CDD:255374	5/18 (28%)
TCB3	NP_013639.1	COG5038	44..1335	CDD:227371	201/1061 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910