DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAB11FIP1 and Rab11fip1

DIOPT Version :9

Sequence 1:	NP_001002814.2	Gene:	RAB11FIP1 / 80223	HGNCID:	30265	Length:	1283	Species:	Homo sapiens
Sequence 2:	XP_036010246.1	Gene:	Rab11fip1 / 75767	MGIID:	1923017	Length:	1170	Species:	Mus musculus

Alignment Length:	1220	Identity:	739/1220 - (60%)
Similarity:	841/1220 - (68%)	Gaps:	135/1220 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPV 65
            |||..|||||.|.:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSLAASAGRGPGTMWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPV 65

Human    66 WREEATFELPSLLSSG--PAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKL 128
            ||||||||||.|||||  |||||||||||||||||||||||||||||||:|||||||||.|||.|
Mouse    66 WREEATFELPPLLSSGAAPAAAATLQLTVLHRALLGLDKFLGRAEVDLRELHRDQGRRKKQWYTL 130

Human   129 KSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAII 193
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||:
Mouse   131 KSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSASDTASAIV 195

Human   194 PSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWD 258
            ||.||||||||||..||||||||||||.|||:|||||||||||||||||.:|||||.||||||||
Mouse   196 PSVTPSVDSDDESFSKDKKKKSKIKTLFSKSSLQKTPLSQSMSVLPTSKSDKVLLRAGDFQSQWD 260

Human   259 EDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNH 323
            :|.:||||||||||||||||:||| :|.||.||:||||||||||||||||||.||||.|||||||
Mouse   261 DDAHEDESSSASDVMSHKRTSSTD-QQPNQSNFSLPKKEGLSFLGGLRSKNDSLSRSTVCINGNH 324

Human   324 VYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKD 388
            ||:|||||:.||::||||:||||:|||:||||||||||||.|.|||.||||.||||:||:|||||
Mouse   325 VYMEQPEARSEIRESSPSNSPSPQGFRRKHLFSSTENLAARSPKEPGEGGGTSSDRRLSDSSTKD 389

Human   389 SLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKD-VAKGSEG 452
            |:|||:|||||  ||.|||.||:|:|||.||.:|.|:|||.||::||||||:|||:| .|||||.
Mouse   390 SMKSMSLPSYR--PLTSGDNRESMSPANVEAARETKDSKKQESKKSSLLSLVTGKRDAAAKGSES 452

Human   453 ENPLTVPGREKE--GMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEA 515
            |...||..:|||  |.|:      :|....|||:||.|||...|.|:.|||||.||||||::|.|
Mouse   453 EPLPTVSEKEKERKGALV------EAQLREEDLMRRPEKDALPVASQWGSSLNPFEDVQISDPGA 511

Human   516 EPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSEL 580
            ..||:|||:||:.:.|.|||:||||||||||||||.|||||| || :...|.||.|.|..|.|:|
Mouse   512 TTESRSEPKPPVPAARVPQTKAVKPRLEVSPEAQPKARLPSP-DS-ALFAPFPSDSIQPPVLSDL 574

Human   581 GHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTPVP 645
            ...::||.|||||. ||..||:|||||||||:|.|| ..:|:|.:|.|.||.:|   ..||||..
Mouse   575 RCDSETQFSESPSA-SSFLSPLAAPISTSTPVEPWP-TGQGEADAEKPSLLLRA---VPSLTPAA 634

Human   646 NSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFP 710
            |:||||.||..:|...|..||||::.....:|.|::::..:|..|
Mouse   635 NTGSSASGSPCEQLPTPVRKGTEEASGDTRKEAGSDESGKTLMTE-------------------- 679

Human   711 CKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPL 775
                                      .||.|..:..||               ...|.||.||||
Mouse   680 --------------------------CVSSVDNVHDGG---------------MTTAGEEAAPPL 703

Human   776 PMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVE---GHSSCPQE 837
             :.....|...:.:|.|.|..|....|||.|||||||||||.||...|...|.|   ||:   |:
Mouse   704 -LEDEASSFHRIAQKHEGMHQNASGGQKKGKKRVSFSEQLFVEEETEGPTRLEEEDRGHA---QQ 764

Human   838 LNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEA 902
            |.....|||:......|||||.|.:.:|.||        |.|.|.    :.|:.:.|.|.|.|||
Mouse   765 LTQEGPVAGSVLRAGSPESPHTEGTGQEPVT--------AEAQPN----ISSEGKCFPEGPTSEA 817

Human   903 SSAKDT-PLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVA 966
            |.|:.| ||  |:.:|.|:...||||||||||||:|||||...||.||||:|||:||||||||||
Mouse   818 SPARGTQPL--MDEKDDLMAPCQSKASDHEGLLSNPLSDLPSASDVKSPIIADLSLSLPSIPEVA 880

Human   967 SDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFR 1031
            |||||:       |:|.|.|:..|...|:.|.....:.....|.....||.|...|..|..||||
Mouse   881 SDDERV-------DEVGDGGKAEKLVDLEAGVSPWNVSHSILETSGRSSGRAGESVPTENQCDFR 938

Human  1032 LQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNPVP 1096
               ||.                     .||.:::||||...||||.:|...|:.|...|.|:.||
Mouse   939 ---PQV---------------------RSSENEELPGPGTVEEEKLIGGEKPASPLCVSQDSSVP 979

Human  1097 SPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPV 1161
            |||.:|.||..:|.|||..|||||||.|||||:|||:.|..|.|||||:||||||||:|||.||.
Mouse   980 SPSVAETFPAAYSSPSSPPSDTHHTSEAESQKQATADVSTSRAENFGKKKPLLQAWVTPSEIHPT 1044

Human  1162 SAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMK 1211
            .|.|.||.|:||||.|||||||..|||:||.||||||||:|||.:|.:||
Mouse  1045 PALPSAGAGAAKHRPHPVKPMNTTATKIANSSLGTATIITENLISEALMK 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB11FIP1	NP_001002814.2	C2_Rab11-FIP_classI	20..147	CDD:176064	122/128 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..281		105/119 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..727		214/399 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..782		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..913		29/78 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..993		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1141		44/103 (43%)
		Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling	1219..1283
		RBD-FIP	1226..1273	CDD:255374
Rab11fip1	XP_036010246.1	C2_Rab11-FIP_classI	20..149	CDD:176064	122/128 (95%)
Rab11fip1	XP_036010246.1	PHA03247	<489..651	CDD:223021	98/168 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83967903
Domainoid	1	1.000	206	1.000	Domainoid score	I24674
eggNOG	1	0.900	-	-		E1_28P66
HGNC	1	1.500	-	-
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11853
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259412at33208
OrthoFinder	1	1.000	-	-		FOG0002878
OrthoInspector	1	1.000	-	-		oto124372
orthoMCL	1	0.900	-	-		OOG6_114278
Panther	1	1.100	-	-	LDO	PTHR15746
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11253
SonicParanoid	1	1.000	-	-		X973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	15.240