Protein Alignment RAB11FIP1 and rab11fip1

DIOPT Version :9

• Sequence 1: NP_001002814.2
• Gene: RAB11FIP1 / 80223
• HGNCID: 30265
• Length: 1283
• Species: Homo sapiens
• Sequence 2: XP_012814911.2
• Gene: rab11fip1 / 734108
• XenbaseID: XB-GENE-982593
• Length: 1056
• Species: Xenopus tropicalis
• Alignment Length: 1335
• Identity: 463/1335 - (34%)
• Similarity: 660/1335 - (49%)
• Gaps: 356/1335 - (26%)

Human    15 WSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLS 79
            |.|||||||||||:||:.||..|::||||:||:|||||:|:|:|:| .||||:||||||:| ||.
 Frog    10 WFPTHVQVTVLQAKGLKPKGKAGSNDAYAIIQLGKEKYSTTVAEKS-QAPVWKEEATFEVP-LLH 72

Human    80 SGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEV 144
            :......|:::.|:||||:|:|||||:.|::|.:||:.:.|||.|||.|:||||||:||||:|||
 Frog    73 NDNQERCTVRVIVMHRALVGMDKFLGQLELNLWELHQSRNRRKVQWYPLRSKPGKKEKERGQIEV 137

Human   145 DIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVK 209
            ::|||||||||||||||||:|||:..|||:||||||..:...||||||:||.. ..|| ||.:..
 Frog   138 EVQFMRNNMTASMFDLSMKEKSRSTLGKLRDKIKGKKHEGFPDTASAIVPSMN-QYDS-DEDMPA 200

Human   210 DKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPE---KVLLRPGDFQSQWDEDDNEDESSSASD 271
            .:|||||:|.|.||..|:|..:|||||||||..|.   |.:|||.:|.|    |......|.||:
 Frog   201 AEKKKSKLKNLFSKPGLKKNSISQSMSVLPTFPPSSSPKTVLRPAEFSS----DFTPPTGSPASE 261

Human   272 --------VMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQ 328
                    :|:||||.|.|..||:.     .||||||...|::.|||.::|||:||||||||:|:
 Frog   262 RRFPHLPVIMTHKRTVSADTSQLSS-----NKKEGLSLFSGMKPKNDPITRSNLCINGNHVYMEE 321

Human   329 PEAKGEI-KDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEG-GGLSSDRQLSESSTKDSLK 391
            .|.:.|. ||||.::  ||:..||..|::|.|||::   |.|.|. ..|..:::.:.:::.||||
 Frog   322 SETRSESPKDSSQTN--SPQIVRKNPLYASAENLSS---KTPKEAKNSLFPEKEQTPAASNDSLK 381

Human   392 SMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPL 456
            |.|:.:.:.:.  |.:......|..|:..||||::||.|:::||||||:|||||..|..|.|:
 Frog   382 SSTVSASQNSK--SEEPISKTPPLPSDVPKEAKDNKKQENKKSSLLSLVTGKKDTPKVPENES-- 442

Human   457 TVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKS 521
                        .|.|.:.....|....::.|:.:..|..:  :|||.|||      :.|.|.|.
 Frog   443 ------------SVAPLKGDMSKATGDNKKIEQSSINVTKK--TSLNPFED------DMEEEKKP 487

Human   522 EPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSP--TDSPSSLPPLPSSSGQASVPSELGHGA 584
            ||     .|.:.:|.||||||:||.||:..|:|.|.  ::|.:|:     |.||..||:.|
 Frog   488 EP-----LPTSAKTSAVKPRLDVSSEAETKAKLSSSSLSNSAASI-----SGGQDGVPTSL---- 538

Human   585 DTQSSESPSVFSSLSSPIAAPIS------TSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTP 643
                .:.|:..::.|||:...:|      ..||:||:                      |:..||
 Frog   539 ----PDFPTASNAPSSPLEHYLSLQCDNKVETPVESY----------------------TDYETP 577

Human   644 -VPNSGSSALGSLFKQPS-------FPANKGTED------SLMGR-TRETGT----EKNTSSLEL 689
             ||....|.| |..|||.       .|.|:.|::      ||:.: ||::.|    :.:|..::|
 Frog   578 SVPLFWRSGL-SQSKQPEPREVHVVEPFNEKTKERKTYVKSLLDQLTRKSPTNSVADADTVDVDL 641

Human   690 EESLPEQPETGRQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRD-LE 753
            .:.:               ||.  ||.||    ..::|..                   |.| ||
 Frog   642 VKGV---------------FPI--QDSSP----FDDIPHT-------------------DTDSLE 666

Human   754 SQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTE 818
            |:...:..:|   ..:|...|.|...|.|                :|.:.|
 Frog   667 SEKSDVQLTK---TLKETPKPAPRTQSAP----------------KKQEPK-------------- 698

Human   819 EAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPAD 883
                             .|:.|.           ||:              |.|.:.......||
 Frog   699 -----------------DEIKPV-----------PPK--------------PAPRSATKVNKAAD 721

Human   884 HLLLPSQEESFSEVPMSEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFK 948
                             :::.|..||     .|.||.| |.::.......:...|:..|.:::.|
 Frog   722 -----------------DSAPASSTP-----PEKALDT-YSNQELQQASNVGSSLNSGQAITEVK 763

Human   949 --SPIMADLNLSL------PSIPEVASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVV 1005
              :|.:::.:|.|      |..||..||||::        :.:||..::.||.
 Frog   764 MATPKISEYSLRLDELPVIPENPEGTSDDEQL--------ETKDDIFSSHSSN------------ 808

Human  1006 PCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLG-KSSSLDKQLPGP 1069
                                          ::|..|.:.:|      .|||. :.:||.|.....
 Frog   809 ------------------------------KSSSAAATRET------NPHLSVQKNSLPKTNDEV 837

Human  1070 SGGEEEKPMGNGSPSPPPGTSLDNPVP----------SPSPSEIFPVTHSF------PSSAHSDT 1118
            ....|:|...|.:|......:..:.:.          |...:...|:..|.      |:|..:|.
 Frog   838 DFALEQKNEKNRNPECVDKINASDAIKISTVSLESQGSDKANHYTPINSSLGYSSPTPASLPTDK 902

Human  1119 HHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMN 1183
            ..|.:|:...|...||: .:|::.||:| ||:||||||||||:......||.|::.|.:|||||:
 Frog   903 CTTPSADPPTKPAIEGT-DKVDSSGKKK-LLRAWVSPSETHPIPTVQSGGTVSSRIRTNPVKPMS 965

Human  1184 AMATKVANCSLGTATIISENL-NNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQ 1247
            |..||       |.:..|:.: :::|.:|||.|:|||.||:|||||||||||||||:.|||||.|
 Frog   966 ATQTK-------TVSGFSQPIKSHDVAIKKYDPTDPAAAYSQLTHDELIQLVLKQKDIISKKEVQ 1023

Human  1248 VRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGK 1282
            :|||||||||||||:|||||::|:   .:.||.||
 Frog  1024 MRELEDYIDNLLVRIMEETPSLLQ---SINKKMGK 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB11FIP1	NP_001002814.2	C2_Rab11-FIP_classI	20..147	CDD:176064	77/126 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..281		63/130 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..727		124/425 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..782		10/41 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	835..913		11/77 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	969..993		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1037..1141		25/120 (21%)
		Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling	1219..1283		47/64 (73%)
		RBD-FIP	1226..1273	CDD:255374	38/46 (83%)
rab11fip1	XP_012814911.2	C2_Rab11-FIP_classI	15..140	CDD:176064	77/126 (61%)
		rad2	<279..>703	CDD:273166	164/588 (28%)
		RBD-FIP	1002..1047	CDD:401421	37/44 (84%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	312	1.000	Domainoid score	I8816
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11853
Inparanoid	1	1.050	450	1.000	Inparanoid score	I8410
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42390
OrthoDB	1	1.010	-	-		D177934at32523
OrthoFinder	1	1.000	-	-		FOG0002878
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15746
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080