DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAB11FIP1 and Rip11

DIOPT Version :9

Sequence 1:	NP_001002814.2	Gene:	RAB11FIP1 / 80223	HGNCID:	30265	Length:	1283	Species:	Homo sapiens
Sequence 2:	NP_573313.2	Gene:	Rip11 / 32850	FlyBaseID:	FBgn0027335	Length:	832	Species:	Drosophila melanogaster

Alignment Length:	1296	Identity:	265/1296 - (20%)
Similarity:	414/1296 - (31%)	Gaps:	508/1296 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    14 VWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLL 78
            :|||||..|||.:||||..||..||::.:..|.:|||||.|||.:::..:..|.||...::|.
  Fly     1 MWSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPD-- 63

Human    79 SSGPAAAATLQLTVLHRALLGLDKFLGRA-----EVDLRDLHRDQGRRKTQWYKLKSKPG--KKD 136
               ....|.|.||.|||..||:|:|||:|     |:|:.|      |.:.:|:||:||||  ||:
  Fly    64 ---QGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYD------RPRAKWFKLESKPGKEKKN 119

Human   137 KERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVD 201
            |||||:||.|.|:..  :.|:.|||.|||.::..|:|...:.|.....|:......|.....|:.
  Fly   120 KERGELEVRIAFVVK--SGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLS 182

Human   202 SDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDF------QSQWDED 260
            |  :..::.|||..:.....|.|      ...|.:.|.|........:.|..      |...:.|
  Fly   183 S--KLHIRSKKKNQEAGADDSSS------FGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEAD 239

Human   261 D---NEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGN 322
            .   :|||.....|.:|||.:.|:                                     :|..
  Fly   240 PGVISEDEDEFVFDNLSHKSSGSS-------------------------------------LNIQ 267

Human   323 HVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTK 387
            .:.|:.|          |..:|:   |..:|......|..:|.....|:|........|.|.::.
  Fly   268 RIGLQPP----------PVGTPN---FTPRHPSPLLNNGVSGVGSGSAKGKQAVLPATLDEDASI 319

Human   388 DS-LKSMTLP-SYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS 450
            |: ::.:.|. |.|.           .|.||:.|:.....|..|...:...:.|....:..|.||
  Fly   320 DAEMEQLELDFSVRA-----------HARANANASASGNASTLPPPSKPPRIPLSQVDEQPAAGS 373

Human   451 -EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPE 514
             |.|.|     :||               |||  |...:.:.|:.:...|..|.
  Fly   374 LEREKP-----KEK---------------PAE--VESDKDEWASKLYGGGKYLE----------- 405

Human   515 AEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSE 579
                        |.|..:.:.|:.:.|:.          ||:..:.|   |||.|||..:|..|:
  Fly   406 ------------IGSSNSLKRRSWEDRVP----------LPASVEEP---PPLHSSSSSSSSSSD 445

Human   580 LGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTPV 644
                :|....:.|.     ::|...|:..|.|:                   |.|...|.|..||
  Fly   446 ----SDDDDEKPPQ-----AAPPPVPVPASLPV-------------------PSAAASTASADPV 482

Human   645 PNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGT------EKNTSSLELEESLPEQPETGRQE 703
            ..:.|    |||.......|..|.::...:..:..:      |.....|.:|...|....|.|.:
  Fly   483 VATSS----SLFSPDVEHRNFDTFNASFAKYEQRNSTAIFADEPELEDLTVELEKPAPTPTARPK 543

Human   704 EELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAA 768
            .:    |....|......:|:|             ....:|.|..|..||::. .|.|.:.|:..
  Fly   544 PQ----PRATADLRAEEEKAKE-------------EAARQLRAEEDARLEAEL-RLNEERLREEE 590

Human   769 EEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSS 833
            |                :|.|:|||        :|:.:|::...||
  Fly   591 E----------------AMQRELEE--------EKERQKQLQMDEQ------------------- 612

Human   834 CPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVP 898
                              :..|:...|:.:|                     ||...:.|.|
  Fly   613 ------------------QRREAKRWEEDQR---------------------LLSFAKRSTS--- 635

Human   899 MSEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIP 963
                                               |.:|:.:.|
  Fly   636 -----------------------------------LEEPVPEKQ--------------------- 644

Human   964 EVASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLC 1028
            |:..:.|.:.:.|.:             .|||...         ||
  Fly   645 ELKHERELVAKQEPE-------------KTLDTAE---------PE------------------- 668

Human  1029 DFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDN 1093
                  |:.:...|.:...||..:....|.....:|:|.....|.:.....|.:         |:
  Fly   669 ------PEHNFLTPEQSPKEFQTNGSGSGSGERWEKRLGKFKYGNKRDKYNNDN---------DS 718

Human  1094 PVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSET 1158
            ..|||..:|...:.|. .|.:|:|.....:|:..||  .||.:        |:.|:
  Fly   719 NSPSPKSTERIIIGHE-KSGSHADRRSEISAQLAKK--YEGKS--------REELM--------- 763

Human  1159 HPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYA 1223
                                                    :|:..:.||.::::.
  Fly   764 ----------------------------------------LIANGMENEALLQRQ---------- 778

Human  1224 QLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIP---TQVGKKAG 1281
                                   :|:|||||:||||:||||..|.||:.|   |...|:.|
  Fly   779 -----------------------RVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKRYG 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB11FIP1	NP_001002814.2	C2_Rab11-FIP_classI	20..147	CDD:176064	58/133 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..281		29/128 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..727		79/405 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..782		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..913		7/77 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..993		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1141		22/103 (21%)
		Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling	1219..1283		21/66 (32%)
		RBD-FIP	1226..1273	CDD:255374	17/46 (37%)
Rip11	NP_573313.2	C2_Rab11-FIP_classI	7..130	CDD:176064	58/133 (44%)
Rip11	NP_573313.2	RBD-FIP	758..805	CDD:255374	22/136 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143768
Domainoid	1	1.000	77	1.000	Domainoid score	I8859
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	167	1.000	Inparanoid score	I4163
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259412at33208
OrthoFinder	1	1.000	-	-		FOG0002878
OrthoInspector	1	1.000	-	-		otm41598
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15746
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.960