DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAB11FIP1 and fic1

DIOPT Version :9

Sequence 1:	NP_001002814.2	Gene:	RAB11FIP1 / 80223	HGNCID:	30265	Length:	1283	Species:	Homo sapiens
Sequence 2:	NP_595651.1	Gene:	fic1 / 2541203	PomBaseID:	SPBC83.18c	Length:	272	Species:	Schizosaccharomyces pombe

Alignment Length:	241	Identity:	52/241 - (21%)
Similarity:	90/241 - (37%)	Gaps:	52/241 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    22 VTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAA 86
            |.:.:|:.|..|...|....|.|.:||:....|...:||...|.|.....|.:||      .:..
pombe    11 VRIWKAKNLPNKALVGKQSPYCVCRVGEVVKRTQTDKRSGQEPSWNAVLEFNIPS------ESYH 69

Human    87 TLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRN 151
            .:::||.|.........:|...:......:::  .:::||:||:    :.:..||:.|..:|:..
pombe    70 IMKITVFHEGFRKHPHLIGDTVLSFEKAMKEE--LQSEWYELKN----EFQFAGELSVQFKFIPT 128

Human   152 NMTASMFD-LSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKS 215
            :  ...|| .|.|...:.|:..                    :.:.||        |.|...|.|
pombe   129 D--PLYFDRASSKPVLQFPYSS--------------------VAALTP--------VPKKPSKPS 163

Human   216 KIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDD 261
            |.:        :|.|:|..:...|.|:.|.|.: |.:......|||
pombe   164 KPR--------KKVPVSHPLPPTPPSREEHVSV-PRESSLFTYEDD 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB11FIP1	NP_001002814.2	C2_Rab11-FIP_classI	20..147	CDD:176064	28/124 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..281		21/101 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..782
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..913
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	969..993
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1141
		Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling	1219..1283
		RBD-FIP	1226..1273	CDD:255374
fic1	NP_595651.1	C2_fungal_Inn1p-like	7..125	CDD:176063	28/125 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910