Protein Alignment FUZ and fy

DIOPT Version :10

• Sequence 1: NP_001339191.1
• Gene: FUZ / 80199
• HGNCID: 26219
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_477500.1
• Gene: fy / 34166
• FlyBaseID: FBgn0001084
• Length: 416
• Species: Drosophila melanogaster
• Alignment Length: 440
• Identity: 128/440 - (29%)
• Similarity: 210/440 - (47%)
• Gaps: 69/440 - (15%)

Human     9 TVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSART-------- 65
            :::||||..:.|:|:|.| .:|..   :.||||.:.||||.|||.::|.:||.:..|
  Fly     2 SIYLLCLTTNGGLPVFTR-KKGEC---ENLPFSTVASLNGFHMFFKSLGIQLEATTTSKQQPIQN 62

Human    66 ------ENTTVVWKSFHDSITLIVLSSEVGISELRLERLLQMVFGAM-VLLVGLEELTNIRNVER 123
                  |..|.:|:. .:||||||....|| ||..|:.|..:||||: :.:....|:.:...::|
  Fly    63 QAPADAEEWTYIWRD-RESITLIVCGCGVG-SEQLLQTLADLVFGAIGMFITRAAEMAHATLLDR 125

Human   124 LKKDLRASYCLIDSFL----GDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVS 184
            ||||.:....::|:.|    ..::|:|    ..||::..|.:.|.:.|:.|:...|:.|..|||.
  Fly   126 LKKDAKKYVPIVDAILEAACAGTQLLG----YTDCLLAAENAQLLQCLNEFSGHCGSLFCCLVVG 186

Human   185 GRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLL 249
            .|:..||||||.|.|.:..||.:|:.| ......|.|||||..||.:.:|.:::.:..:..||:|
  Fly   187 HRIAVATEGWWDLDTRDRELLLFLLNS-SSTMQHDVPVYLPVKSPHIAYRFVSIPVASNSALCVL 250

Human   250 CG-PSPPLSQLYPQLLERWWQP--LLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLF 311
            || .:....:|:...:..:...  ||.....|:   ||:||....:..::|.::|::...::.||
  Fly   251 CGAENASFRELHAHAMSAYRNEGNLLAAAERCV---PRSLPEHLEIDGNVLAIILINRHTRKSLF 312

Human   312 T--------VEPL--GDKAEPSPEQRRRLLRNFY--TLVTSTHFPPEPGPPEKTEDEVYQAQLPR 364
            |        |:.:  ||.      ||..:|:.|:  |:.....|..:....:.|..:.|......
  Fly   313 TRNLNQSASVKRIIVGDL------QRLDILKKFFDQTMDAVHQFETQSSSNKTTLVDQYSCSDYH 371

Human   365 ACYLVLGTEEPGTGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHA 414
            .||..:.             :|| ..:.||.....|:|.:|.|| ..:||
  Fly   372 KCYAHMD-------------ELG-NVIFLLFVAAVPSHAMRFLA-QRIHA 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FUZ	NP_001339191.1	Fuzzy	12..417	CDD:411043	128/437 (29%)
fy	NP_477500.1	Fuzzy	5..410	CDD:411043	128/437 (29%)